2013年9月
Repositioning metformin for cancer prevention and treatment
TRENDS IN ENDOCRINOLOGY AND METABOLISM
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- 巻
- 24
- 号
- 9
- 開始ページ
- 469
- 終了ページ
- 480
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.tem.2013.05.004
- 出版者・発行元
- ELSEVIER SCIENCE LONDON
Metformin is the most commonly prescribed drug for type 2 diabetes (T2DM). Retrospective studies show that metformin is associated with decreased cancer risk. This historical correlation has driven vigorous research campaigns to determine the anticancer mechanisms of metformin. Consolidating the preclinical data is a challenge because unanswered questions remain concerning relevant mechanisms, bioavailability, and genetic factors that confer metformin sensitivity. Perhaps the most important unanswered question is whether metformin has activity against cancer in non-diabetics. In this review we highlight the proposed mechanisms of metformin action in cancer and discuss ongoing clinical trials with metformin in cancer. Improved understanding of these issues will increase the chances for successful application of metformin as an inexpensive, well-tolerated, and effective anticancer agent.
- リンク情報
- ID情報
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- DOI : 10.1016/j.tem.2013.05.004
- ISSN : 1043-2760
- PubMed ID : 23773243
- Web of Science ID : WOS:000324784800006