Kazuya Miyagawa

Profile Information

Affiliation: 准教授, 薬学部, 国際医療福祉大学

Degree: 博士（薬学）

J-GLOBAL ID: 201801004051369002
researchmap Member ID: B000327697

Research Interests

Research Areas

Research History

Apr, 2020 - Present

School of Pharmacy, International University of Health and Welfare
Apr, 2013 - Mar, 2020

School of Pharmacy, International University of Health and Welfare
Apr, 2007 - Mar, 2013

School of Pharmacy, International University of Health and Welfare

Education

Apr, 2004 - Mar, 2007

Hoshi University
Apr, 2002 - Mar, 2004

Hoshi University
Apr, 1998 - Mar, 2002

Hoshi University, Hoshi University

Committee Memberships

Awards

Papers

Polarization to M1-type microglia in the hippocampus is involved in depression-like behavior in a mouse model of olfactory dysfunction.

Kohei Takahashi, Minoru Tsuji, Osamu Nakagawasai, Soh Katsuyama, Kazuya Miyagawa, Kazuhiro Kurokawa, Atsumi Mochida-Saito, Hiroshi Takeda, Takeshi Tadano

Neurochemistry international, 105723-105723, Mar 13, 2024
Repeated antibiotic drug treatment negatively affects memory function and glutamatergic nervous system of the hippocampus in mice.

Kohei Takahashi, Kazuhiro Kurokawa, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji

Neuroscience letters, 825 137711-137711, Mar 1, 2024
Upper Respiratory Symptoms as Long COVID: Insight from a Multicenter Cohort Study.

Masahiko Okada, Noriyuki Ishida, Sho Kanzaki, Ichiro Kawada, Kengo Nagashima, Hideki Terai, Gaku Hiruma, Ho Namkoong, Takanori Asakura, Katsunori Masaki …

OTO open, 8(1) e120, 2024
Hippocampal and gut AMPK activation attenuates enterocolitis-like symptoms and co-occurring depressive-like behavior in ulcerative colitis model mice: Involvement of brain-gut autophagy.

Kohei Takahashi, Kazuhiro Kurokawa, Lihua Hong, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji

Experimental neurology, 373 114671-114671, Dec 30, 2023
Comprehensive analysis of long COVID in a Japanese nationwide prospective cohort study.

Hideki Terai, Makoto Ishii, Ryo Takemura, Ho Namkoong, Kyoko Shimamoto, Katsunori Masaki, Takae Tanosaki, Shotaro Chubachi, Emiko Matsuyama, Reina Hayashi …

Respiratory investigation, 61(6) 802-814, Nov, 2023
Possible involvement of inflammasomes on the post-stroke cognitive impairment in a mouse model of embolic cerebral infarct.

Ayae Nomura, Kazuhiro Kurokawa, Kohei Takahashi, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji

Physiology & behavior, 271 114348-114348, Sep 12, 2023
Real-world effects of once-daily inhaled steroid (fluticasone furoate) combined with long-acting beta-2 agonist (vilanterol) and long-acting muscarinic antagonist (umeclidinium) on lung function tests of asthma patients in Japan

Akira Umeda, Hisato Shimada, Tateki Yamane, Taichi Mochizuki, Yasushi Inoue, Kenji Tsushima, Kazuya Miyagawa, Atsumi Mochida, Hiroshi Takeda, Yasumasa Okada …

Frontiers in Physiology, 14 1131949-1131949, Apr 21, 2023 Peer-reviewed
Brexpiprazole prevents colitis-induced depressive-like behavior through myelination in the prefrontal cortex.

Kohei Takahashi, Lihua Hong, Kazuhiro Kurokawa, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji

Progress in neuro-psychopharmacology & biological psychiatry, 121 110666-110666, Mar 8, 2023
Donepezil prevents olfactory dysfunction and α-synuclein aggregation in the olfactory bulb by enhancing autophagy in zinc sulfate-treated mice.

Kohei Takahashi, Minoru Tsuji, Osamu Nakagawasai, Soh Katsuyama, Lihua Hong, Kazuya Miyagawa, Kazuhiro Kurokawa, Atsumi Mochida-Saito, Hiroshi Takeda, Takeshi Tadano

Behavioural brain research, 438 114175-114175, Oct 26, 2022
The whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force.

Qingbo S Wang, Ryuya Edahiro, Ho Namkoong, Takanori Hasegawa, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Ho Lee, Ryunosuke Saiki, Takayoshi Hyugaji …

Nature communications, 13(1) 4830-4830, Aug 22, 2022
DOCK2 is involved in the host genetics and biology of severe COVID-19.

Ho Namkoong, Ryuya Edahiro, Tomomi Takano, Hiroshi Nishihara, Yuya Shirai, Kyuto Sonehara, Hiromu Tanaka, Shuhei Azekawa, Yohei Mikami, Ho Lee …

Nature, 609(7928) 754-760, Aug 8, 2022
Correlation between the reduction in hippocampal SirT2 expression and depressive-like behaviors and neurological abnormalities in olfactory bulbectomized mice.

Kohei Takahashi, Kazuhiro Kurokawa, Lihua Hong, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji

Neuroscience research, 182 76-80, Jun 6, 2022
Possible role of transcriptional regulation of 5-HT1A receptor in the midbrain on unadaptation to stress in mice.

Hiroko Miyagishi, Minoru Tsuji, Kazuya Miyagawa, Kazuhiro Kurokawa, Atsumi Mochida-Saito, Kohei Takahashi, Yasuhiro Kosuge, Kumiko Ishige, Hiroshi Takeda

Brain research, 1783 147859-147859, Mar 1, 2022
Antidepressant effects of Enterococcus faecalis 2001 through the regulation of prefrontal cortical myelination via the enhancement of CREB/BDNF and NF-κB p65/LIF/STAT3 pathways in olfactory bulbectomized mice.

Kohei Takahashi, Kazuhiro Kurokawa, Lihua Hong, Kazuya Miyagawa, Atsumi Mochida-Saito, Masahiro Iwasa, Hiroyuki Iwasa, Osamu Nakagawasai, Takeshi Tadano, Hiroshi Takeda …

Journal of psychiatric research, 148 137-148, Jan 29, 2022
Effects of smoking cessation using varenicline on the serum concentrations of oxidized high-density lipoprotein: Comparison with high-density lipoprotein cholesterol.

Akira Umeda, Kazuya Miyagawa, Atsumi Mochida, Hiroshi Takeda, Yoshiyuki Ohira, Toru Kato, Yasumasa Okada, Kazuhiko Kotani

PloS one, 17(11) e0277766, 2022
Trichostatin A, a histone deacetylase inhibitor, alleviates the emotional abnormality induced by maladaptation to stress in mice.

Hidenao Kimijima, Kazuya Miyagawa, Kazuhiro Kurokawa, Atsumi Mochida-Saito, Kohei Takahashi, Hiroshi Takeda, Minoru Tsuji

Neuroscience letters, 766 136340-136340, Jan 1, 2022
Activation of 5-HT1A receptor reduces abnormal emotionality in stress-maladaptive mice by alleviating decreased myelin protein in the ventral hippocampus.

Kazuhiro Kurokawa, Kohei Takahashi, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji

Neurochemistry international, 151 105213-105213, Dec, 2021
Disturbance of prefrontal cortical myelination in olfactory bulbectomized mice is associated with depressive-like behavior.

Kohei Takahashi, Kazuhiro Kurokawa, Lihua Hong, Kazuya Miyagawa, Atsumi Mochida-Saito, Hiroshi Takeda, Minoru Tsuji

Neurochemistry international, 148 105112-105112, Sep, 2021
Effects of Gadolinium Deposition in the Brain on Motor or Behavioral Function: A Mouse Model.

Hiroyuki Akai, Kazuya Miyagawa, Kohei Takahashi, Atsumi Mochida-Saito, Kazuhiro Kurokawa, Hiroshi Takeda, Minoru Tsuji, Haruto Sugawara, Koichiro Yasaka, Akira Kunimatsu …

Radiology, 301(2) 210892-210892, Aug 31, 2021
Recent Insights into the Measurement of Carbon Dioxide Concentrations for Clinical Practice in Respiratory Medicine.

Akira Umeda, Masahiro Ishizaka, Akane Ikeda, Kazuya Miyagawa, Atsumi Mochida, Hiroshi Takeda, Kotaro Takeda, Isato Fukushi, Yasumasa Okada, David Gozal

Sensors (Basel, Switzerland), 21(16), Aug 21, 2021

Misc.

341

妊娠期におけるストレス曝露が誘発する仔の情動障害に対する抑肝散母仔同服の効果

宮川和也, 持田淳美[齋藤], 黒川和宏, 高橋浩平, 武田弘志, 辻稔

ストレス科学, 38(1) 339-339, 2023
ATP感受性カリウムチャネルの調節が情動およびストレス応答に及ぼす影響

持田淳美[齋藤], 宮川和也, 黒川和宏, 高橋浩平, 武田弘志, 辻稔

ストレス科学, 38(1) 340-340, 2023
潰瘍性大腸炎に併発する不安神経症モデル動物の妥当性に関する検討

高橋浩平, 黒川和宏, 宮川和也, 持田淳美[齋藤], 武田弘志, 辻稔

ストレス科学, 38(1) 340-340, 2023
5-HT1A受容体の刺激はストレス非適応モデルマウスにおいてGSK3βを介してオリゴデンドロサイト転写因子を誘導する

黒川和宏, 高橋浩平, 野村彩衣, 宮川和也, 持田淳美[齋藤], 武田弘志, 辻稔

ストレス科学, 38(1) 341-341, 2023
塞栓性脳梗塞後に併発するうつ病モデル動物の作製

野村彩衣, 黒川和宏, 高橋浩平, 宮川和也, 持田淳美, 武田弘志, 辻稔

ストレス科学, 38(1) 341-341, 2023
ストレス適応と5-HT_1A受容体を介した髄鞘形成との関連性

黒川和宏, 髙橋浩平, 宮川和也, 持田(斎藤) 淳美, 武田弘志, 辻稔

次世代薬理学セミナー要旨集, 2023.1 AG-1, 2023
ミエリン－オリゴデンドロサイトに着目したうつ病の病態並びに新規治療法に関する検討

髙橋浩平, 黒川和宏, 宮川和也, 持田(斎藤) 淳美, 武田弘志, 辻稔

次世代薬理学セミナー要旨集, 2023.1 AG-2, 2023
脳内ドパミン神経系の機能調節におけるKir6.2遺伝子の関与

持田淳美[齋藤], 宮川和也, 黒川和宏, 高橋浩平, 梅田啓, 岡田泰昌, 武田弘志, 辻稔

ストレス科学, 37(2) 105-105, Nov, 2022
潰瘍性大腸炎に併発する不安神経症のモデル動物の作製

高橋浩平, 黒川和宏, 宮川和也, 持田淳美[齋藤], 武田弘志, 辻稔

ストレス科学, 37(2) 106-106, Nov, 2022
間欠的低酸素負荷マウスの情動的行動特性と脳機能変化

宮川和也, 持田淳美[齋藤], 黒川和宏, 高橋浩平, 梅田啓, 岡田泰昌, 武田弘志, 辻稔

ストレス科学, 37(2) 107-107, Nov, 2022
ストレス適応及び非適応モデルマウスにおけるオリゴデンドロサイト転写因子の経時的変化

黒川和宏, 高橋浩平, 宮川和也, 持田淳美[齋藤], 武田弘志, 辻稔

ストレス科学, 37(2) 108-108, Nov, 2022
脳内ドパミン神経系の機能調節におけるKir6.2遺伝子の関与

持田淳美[齋藤], 宮川和也, 黒川和宏, 高橋浩平, 梅田啓, 岡田泰昌, 武田弘志, 辻稔

ストレス科学, 37(2) 105-105, Nov, 2022
潰瘍性大腸炎に併発する不安神経症のモデル動物の作製

高橋浩平, 黒川和宏, 宮川和也, 持田淳美[齋藤], 武田弘志, 辻稔

ストレス科学, 37(2) 106-106, Nov, 2022
間欠的低酸素負荷マウスの情動的行動特性と脳機能変化

宮川和也, 持田淳美[齋藤], 黒川和宏, 高橋浩平, 梅田啓, 岡田泰昌, 武田弘志, 辻稔

ストレス科学, 37(2) 107-107, Nov, 2022
ストレス適応及び非適応モデルマウスにおけるオリゴデンドロサイト転写因子の経時的変化

黒川和宏, 高橋浩平, 宮川和也, 持田淳美[齋藤], 武田弘志, 辻稔

ストレス科学, 37(2) 108-108, Nov, 2022
PCD診断補助を目的とする42種類の遺伝子DNAパネルの有用性

梅田啓, 宮川和也, 福永興壱

国際医療福祉大学学会誌, 27(抄録号) 190-190, Aug, 2022
Resveratrol prevents dextran sulfate sodium-induced colitis-like symptoms and depressive-like behavior by activation of AMP-activated protein kinase pathways in the brain-gut

Takahashi Kohei, Kurokawa Kazuhiro, Hong Lihua, Miyagawa Kazuya, Mochida-Saito Atsumi, Takeda Hiroshi, Tsuji Minoru

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 96 4-B-P-292, 2022
5-HT_1A receptor activation induces oligodendrocyte transcription factors via the Gab1/GSK3β signaling pathway in stress-maladaptive mice

Kurokawa Kazuhiro, Takahashi Kohei, Miyagawa Kazuya, Mochida-Saito Atsumi, Takeda Hiroshi, Tsuji Minoru

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 96 4-B-P-281, 2022
The involvement of inflammasomes on the learning and memory impairment in a mouse model of embolic stroke

Nomura Ayae, Kurokawa Kazuhiro, Takahashi Kohei, Miyagawa Kazuya, Mochida-Saito Atsumi, Takeda Hiroshi, Tsuji Minoru

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 96 1-B-SS09-1, 2022
脳腸相関の概念に基づいたうつ病と脳内ミエリン形成との関連性の解明

高橋浩平, 黒川和宏, 宮川和也, 持田(齋藤)淳美, 武田弘志, 辻稔

国際医療福祉大学学会誌, 27, 2022

Books and Other Publications

行動医学テキスト第2版

武田弘志, 宮川和也, 辻稔 (Role: Joint author, 行動と遺伝（エピジェネティクス）)

中外医学社, Mar, 2023
神経・筋・精神/麻酔・鎮痛

赤池, 昭紀, 高橋, 良輔(臨床神経学), 武田, 弘志, 乾, 賢一 (Role: Contributor, 心身症)

中山書店, 2019 (ISBN: 9784521744513)
神経・筋・精神/麻酔・鎮痛

赤池, 昭紀, 高橋, 良輔(臨床神経学), 武田, 弘志, 乾, 賢一 (Role: Contributor, 不安症（パニック障害、全般性不安障害など）)

中山書店, 2019 (ISBN: 9784521744513)
Facilitating Resilience After PTSD: A Translational Approach

Kazuya Miyagawa, Minoru Tsuji, Hiroshi Takeda (Role: Joint author, Chapter 6. Role of Epigenetic Mechanisms in the Post-traumatic Stress Disorder and Stress Resistance)

Nova Science Publishers, Inc., Jan, 2018
行動医学テキスト

武田弘志, 宮川和也, 辻稔, 日本行動医学会, 野村忍, 堤明純, 島津明人, 中尾睦浩, 吉内一浩 (Role: Contributor, 行動と遺伝（エピジェネティクス）)

中外医学社, Oct, 2015 (ISBN: 4498048288)
ストレス百科事典

George Fink, ストレス百科事典翻訳刊行委員会 (Role: Joint translator, 海馬(概観)、胎性期ストレス) (Original Author(s): George Fink)

丸善, Jan, 2010 (ISBN: 462108111X)
臨床緩和医療薬学

武田弘志, 宮川和也, 辻稔, 日本緩和医療薬学会企画委員会 (Role: Contributor, Ⅵ. 非オピオイド性鎮痛薬各論 5. その他のオピオイド)

真興交易医書出版部, Oct, 2008 (ISBN: 4880038199)

Major Teaching Experience

Professional Memberships

Research Projects

妊娠期の低酸素状態が子の情動的ストレス応答に及ぼす影響と抑肝散の治療効果

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2022 - Mar, 2025

宮川和也
新規抗うつ薬開発を指向したアストロサイト由来LIFのストレス適応促進作用の証明

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

辻稔, 宮川和也, 黒川和宏, 高橋浩平
Effect of running exercise on myelin damage caused by maladaptation to stress in female mice

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Elucidation of the treatment mechanism of yokukansan for emotional abnormality of offspring induced by stress exposure during pregnancy

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022
Elucidation of stress adaptative mechanisms focusing on myelination and application to development of new therapeutic agents for depressive disorder

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2017 - Mar, 2021

Tsuji Minoru
Effects of yokukansan to stress vulnerability in offspring induced by prenatal stress exposure

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2020

Miyagawa Kazuya
The function of Na^+channel as a novel target molecule for chronic pain treatment in thalamus neuron

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

AMANO Taku, NAKATANI Yoshihiko, TSUJI Minoru, MIYAGAWA Kazuya, KATOH Hideaki

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Research Interests

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Research History

Education

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Awards

Papers

Misc.

Books and Other Publications

Major Teaching Experience

Professional Memberships

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