2020年10月13日
Contributions of histone variants in nucleosome structure and function.
Journal of molecular biology
- ,
- ,
- 巻
- 433
- 号
- 6
- 開始ページ
- 166678
- 終了ページ
- 166678
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jmb.2020.10.012
Chromatin compacts genomic DNA in eukaryotes. The primary chromatin unit is the nucleosome core particle, composed of four pairs of the core histones, H2A, H2B, H3, and H4, and 145-147 base pairs of DNA. Since replication, recombination, repair, and transcription take place in chromatin, the structure and dynamics of the nucleosome must be versatile. These nucleosome characteristics underlie the epigenetic regulation of genomic DNA. In higher eukaryotes, many histone variants have been identified as non-allelic isoforms, which confer nucleosome diversity. In this article, we review the manifold types of nucleosomes produced by histone variants, which play important roles in the epigenetic regulation of chromatin.
- リンク情報
- ID情報
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- DOI : 10.1016/j.jmb.2020.10.012
- PubMed ID : 33065110