Kazuya Kusama

Profile Information

Affiliation: School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

Degree: 博士（薬学）

Researcher number: 30579149
J-GLOBAL ID: 201801014842255944
researchmap Member ID: B000294791

Research Interests

Research Areas

Research History

Apr, 2022 - Present

School of Pharmacy School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
Jul, 2019 - Mar, 2022

Assistant Professor, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
Aug, 2016 - Jun, 2019

Research Assistant Professor, Graduate School of Agricultural and Life Sciences, The University of Tokyo
Apr, 2014 - Jul, 2016

Project Researcher, Graduate School of Agricultural and Life Sciences, The University of Tokyo
May, 2015 - Aug, 2015

Visiting Scientist, Department of Genetics, Albert Einstein College of medicine

Education

Apr, 2009 - Mar, 2014

Graduate School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
Apr, 2005 - Mar, 2009

School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

Awards

May, 2023

薬理系薬学部会奨励賞, 日本薬学会薬理系薬学部会

草間和哉
Jul, 2017

USDA-NIFA-AFRI Merit Award, Society for the Study of Reproduction (SSR) 50th Annual Meeting

Kazuya Kusama
Sep, 2015

優秀発表賞, 第108回日本繁殖生物学会

草間和哉
Nov, 2014

優秀発表賞, 関東畜産学会第69回大会

草間和哉
Mar, 2013

優秀発表賞, 日本薬学会第133年会

草間和哉
Sep, 2012

The Y.W. Loke New Investigator Travel Award, International Federation of Placenta Associations (IFPA) Meeting 2012

Kazuya Kusama

Papers

Downregulation of PGRMC1 accelerates differentiation and fusion of a human trophoblast cell line.

Atsuya Tsuru, Mikihiro Yoshie, Mei Suzuki, Hiroki Mochizuki, Satoshi Kametaka, Takako Ohmaru-Nakanishi, Mana Azumi, Kazuya Kusama, Kiyoko Kato, Kazuhiro Tamura

The Journal of endocrinology, 260(2), Feb 1, 2024
ミトコンドリア酵素ジヒドロオロト酸デヒドロゲナーゼは胎盤栄養膜細胞の融合を調節する

吉田佳乃子, 草間和哉, 安曇麻奈, 吉江幹浩, 田村和広, 小島淳哉, 小野政徳, 西洋孝

東京医科大学雑誌, 81(4) 434-435, Oct, 2023
Expression of NFIL3 and CEBPA regulated by IFNT induced-PGE2 in bovine endometrial stromal cells during the pre-implantation period.

Rulan Bai, Kazuya Kusama, Yuta Matsuno, Hanako Bai, Toshihiro Sakurai, Koji Kimura, Kazuhiko Imakawa

Frontiers in endocrinology, 14 1075030-1075030, 2023
Cordyceps militaris Extract and the Main Component, Cordycepin, Modulate the Functions of Prostate Cancer Cells Partially Through the Adenosine A1 Receptor

Kazuya Kusama, Takumi Suzuki, Ryosuke Motohashi, Takumi Nobusawa, Koichiro Ota, Mana Azumi, Mikihiro Yoshie, Hiroaki Miyaoka, Kazuhiro Tamura

Natural Product Communications, 17(10) 1934578X2211308-1934578X2211308, Oct 6, 2022
Intrauterine infusion of low levels of interferon-tau on day-8 post-estrus stimulates the bovine endometrium to secrete apolipoprotein-A1: A possible implication for early embryo tolerance.

Mohammad B Rashid, Mohamed A Marey, Kenji Fukuda, Shingo Haneda, Kazuya Kusama, Masayuki Shimada, Kazuhiko Imakawa, Akio Miyamoto

American journal of reproductive immunology (New York, N.Y. : 1989), 88(3) e13592, Sep, 2022
Origination of LTR Retroelement-Derived NYNRIN Coincides with Therian Placental Emergence.

Arnon Plianchaisuk, Kazuya Kusama, Kiyoko Kato, Sira Sriswasdi, Kazuhiro Tamura, Wataru Iwasaki

Molecular biology and evolution, 39(9), Sep 1, 2022
Endogenous Retroviruses and Placental Evolution, Development, and Diversity.

Kazuhiko Imakawa, Kazuya Kusama, Tomoko Kaneko-Ishino, So Nakagawa, Koichi Kitao, Takayuki Miyazawa, Fumitoshi Ishino

Cells, 11(15), Aug 8, 2022
PGRMC1 Regulates Cellular Senescence via Modulating FOXO1 Expression in Decidualizing Endometrial Stromal Cells.

Atsuya Tsuru, Mikihiro Yoshie, Junya Kojima, Ryo Yonekawa, Mana Azumi, Kazuya Kusama, Hirotaka Nishi, Kazuhiro Tamura

Biomolecules, 12(8), Jul 28, 2022
Characterization of Serum Metabolome and Proteome Profiles Identifies SNX5 Specific for Pregnancy Failure in Holstein Heifers

Kazuya Kusama, Rulan Bai, Yuta Matsuno, Atsushi Ideta, Toshihiro Sakurai, Kentaro Nagaoka, Masatoshi Hori, Kazuhiko Imakawa

Life, 12(2) 309-309, Feb 18, 2022
Alpha 1 Antitrypsin Regulates Trophoblast Syncytialization and Inflammatory Factor Expression.

Kanoko Yoshida, Aruto Yano, Kazuya Kusama, Gen Ishikawa, Kazuhiro Tamura

International journal of molecular sciences, 23(4), Feb 10, 2022
Characterization of lncRNA functioning in ovine conceptuses and endometria during the peri-implantation period

Yuta Matsuno, Kazuya Kusama, Kazuhiko Imakawa

Biochemical and Biophysical Research Communications, 594 22-30, Feb, 2022
Toll-like receptor signaling pathway triggered by inhibition of serpin A1 stimulates production of inflammatory cytokines by endometrial stromal cells.

Kazuya Kusama, Ayaka Satoyoshi, Mana Azumi, Mikihiro Yoshie, Junya Kojima, Yumi Mizuno, Masanori Ono, Hirotaka Nishi, Takeshi Kajihara, Kazuhiro Tamura

Frontiers in endocrinology, 13 966455-966455, 2022
PGE2 and Thrombin Induce Myofibroblast Transdifferentiation via Activin A and CTGF in Endometrial Stromal Cells

Kazuya Kusama, Yuta Fukushima, Kanoko Yoshida, Mana Azumi, Mikihiro Yoshie, Yumi Mizuno, Takeshi Kajihara, Kazuhiro Tamura

Endocrinology, 162(12), Dec 1, 2021
The effect of bta-miR-26b in intrauterine extracellular vesicles on maternal immune system during the implantation period.

Keigo Nakamura, Kazuya Kusama, Masatoshi Hori, Kazuhiko Imakawa

Biochemical and biophysical research communications, 573 100-106, Oct 8, 2021
Possible Roles of Calreticulin in Uterine Decidualization and Receptivity in Rats and Humans.

Mikihiro Yoshie, Kazuya Kusama, Risaka Tanaka, Takanori Okubo, Junya Kojima, Yotaro Takaesu, Keiichi Isaka, Hirotaka Nishi, Kazuhiro Tamura

International journal of molecular sciences, 22(19), Sep 29, 2021
Senolytic treatment modulates decidualization in human endometrial stromal cells.

Kazuya Kusama, Naoya Yamauchi, Kanoko Yoshida, Mana Azumi, Mikihiro Yoshie, Kazuhiro Tamura

Biochemical and biophysical research communications, 571 174-180, Sep 24, 2021
Heat stress induces oxidative stress and activates the KEAP1-NFE2L2-ARE pathway in bovine endometrial epithelial cells.

Hirona Murata, Hiroki Kunii, Kazuya Kusama, Toshihiro Sakurai, Hanako Bai, Manabu Kawahara, Masashi Takahashi

Biology of reproduction, 105(5) 1114-1125, Jul 22, 2021
Impact of serine protease inhibitor alpha1-antitrypsin on expression of endoplasmic reticulum stress-induced proinflammatory factors in adipocytes.

Yukari Ando, Akito Kuroda, Kazuya Kusama, Takeshi Matsutani, Akihisa Matsuda, Kazuhiro Tamura

Biochemistry and biophysics reports, 26 100967-100967, Jul, 2021
Endometrial epithelial–mesenchymal transition (EMT) by menstruation-related inflammatory factors during hypoxia

K Kusama, Y Fukushima, K Yoshida, H Sakakibara, N Tsubata, M Yoshie, J Kojima, H Nishi, K Tamura

Molecular Human Reproduction, 27(6), May 29, 2021
Neutrophils recognize and amplify IFNT signals derived from day 7 bovine embryo for stimulation of ISGs expression in vitro: A possible implication for the early maternal recognition of pregnancy.

Mariani F Fiorenza, Mohamed A Marey, Mohammad B Rashid, Mohammad A Zinnah, Dongxue Ma, Vernadyn A Morillo, Kazuya Kusama, Masayuki Shimada, Kazuhiko Imakawa, Alfredo Q Antoniazzi …

Biochemical and biophysical research communications, 553 37-43, May 14, 2021

Misc.

脂肪細胞における小胞体ストレス応答性サイトカインとα1-アンチトリプシン発現

八代有未, 草間和哉, 安藤友香理, 松谷毅, 松田明久, 谷合信彦, 吉田寛, 田村和広

Shock: 日本Shock学会雑誌, 35(1) 57-57, May, 2021
子宮内膜症細胞の上皮間葉系転換におけるCXCL12-CXCR4経路の役割

草間和哉, 吉江幹浩, 田村和広

日本内分泌学会雑誌, 97(1) 285-285, Apr, 2021
子宮内膜間質細胞の脱落膜化過程における細胞老化とプロゲステロン受容体膜構成因子1との関係

吉江幹浩, 津留涼也, 小島淳哉, 草間和哉, 西洋孝, 田村和広

日本内分泌学会雑誌, 96(4) 1066-1066, Apr, 2021
子宮内膜細胞におけるCXCR4-CXCL12経路活性化と上皮間葉系転換

福島優太, 草間和哉, 吉田佳乃子, 吉江幹浩, 小島淳哉, 西洋孝, 水野由美, 梶原健, 田村和広

日本内分泌学会雑誌, 96(4) 1073-1073, Apr, 2021
妊娠成立時の子宮内膜分化過程で起こるプロゲステロン受容体膜構成因子1と細胞老化

津留涼也, 吉江幹浩, 小島淳哉, 草間和哉, 西洋孝, 井坂惠一, 田村和広

日本薬学会年会要旨集, 141年会 29V06-pm08S, Mar, 2021
子宮内膜機能に及ぼす月経血中の炎症誘導因子の作用

福島優太, 草間和哉, 吉江幹浩, 田村和広

日本薬学会年会要旨集, 141年会 29V06-pm09S, Mar, 2021
胎盤栄養膜細胞における小胞体ストレスを介したAlpha 1 antitrypsinの役割

吉田佳乃子, 草間和哉, 吉江幹浩, 石川源, 加藤聖子, 田村和広

日本薬学会年会要旨集, 141年会 29V06-pm10S, Mar, 2021
妊娠ウシにおける子宮内エクソソームのIFNT非依存的な効果

中村圭吾, 草間和哉, 出田篤司, 須田義人, 今川和彦, 堀正敏

The Journal of Reproduction and Development, 66(Suppl.) j40-j40, Sep, 2020
ヒツジ栄養膜細胞由来のフィブリンによる胚-子宮上皮細胞間の接着制御モデル

松野雄太, 草間和哉, 今川和彦

The Journal of Reproduction and Development, 66(Suppl.) j82-j82, Sep, 2020
ヒト子宮内膜脱落膜細胞におけるEPAC-C/EBP βを介したプロラクチン発現機構

草間和哉, 吉江幹浩, 田村和広

日本内分泌学会雑誌, 96(1) 264-264, Aug, 2020
更年期モデルラットにおける沖縄産エリ蚕に寄生する冬虫夏草の子実体エキスのテストステロン維持作用

宮川真由子, 草間和哉, 太田浩一朗, 岡松滋美, 仲宗根豊一, 宮岡宏明, 田村和広

日本薬学会年会要旨集, 140年会 27K-pm12S, Mar, 2020
子宮内膜細胞の低酸素刺激下におけるEMT関連因子CXCR4の発現変動

津端夏王也, 草間和哉, 田村和広

日本薬学会年会要旨集, 140年会 27K-pm13S, Mar, 2020
ヒト前立腺がん細胞の増殖に及ぼす沖縄産エリ蚕蛹を宿主とする子実体エキスの影響

佐伯郁, 桑原直子, 草間和哉, 太田浩一朗, 岡松滋美, 仲宗根豊一, 宮岡宏明, 田村和広

日本薬学会年会要旨集, 140年会 28P-am133S, Mar, 2020
低酸素条件下の子宮内膜細胞における上皮間葉系転換関連因子CXCR4の発現

草間和哉, 榊原はづき, 津端夏王也, 小島淳哉, 西洋孝, 吉江幹浩, 田村和広

日本内分泌学会雑誌, 95(4) 1549-1549, Feb, 2020
ウシ胎盤細胞融合における内在性レトロウイルス遺伝子の発現制御機構の解明

草間和哉, 田村和広, 堀正敏, 今川和彦

日本繁殖生物学会大会講演要旨, 65(Suppl) j 81-j81, Sep, 2019 Peer-reviewed
子宮内エクソソームmiR-98による胚接着時の母体免疫系の抑制

中村圭吾, 草間和哉, 出田篤司, 今川和彦, 堀正敏

日本繁殖生物学会大会講演要旨, 65(Suppl) j 58-j58, Sep, 2019 Peer-reviewed
Examination of Holstein cattle resistant to enzootic bovine leukosis (EBL)-incidence

今川和彦, 稲垣靖子, 須田義人, 小林朋子, 草間和哉

Proceedings of the Asian Agricultural Symposium, 18th, 2018
牛白血病撲滅を目指して：新たなアプローチの必要性

今川和彦, 草間和哉, 白汝嵐, 稲垣靖子

MPアグロジャーナル, 33 25-28, 2018 Invited
ホルスタイン種の牛白血病(EBL)発症閾値形質に関する遺伝率の推定

稲垣靖子, 須田義人, 小林朋子, 草間和哉, 今川和彦

日本畜産学会大会講演要旨, 123rd 111-111, Sep 6, 2017
cAMPとPPARGによるウシ胎盤形成誘導因子ERVsの発現調節

草間和哉, 白汝嵐, 出田篤司, 青柳敬人, 今川和彦

日本畜産学会大会講演要旨, 122nd 162, Mar 28, 2017

Books and Other Publications

最新薬理学要説ー薬の効き方の基礎を学ぶー

田村和広, 吉江幹浩, 舩田正彦, 鈴木勉, 草間和哉, 宮岡宏明 (Role: Joint author)

愛智出版, Apr, 2020
不妊・不育診療指針

柴原, 浩章 (Role: Contributor, 着床)

中外医学社, Nov, 2016 (ISBN: 9784498060807)

Major Professional Memberships

Research Projects

Analysis of differentiation mechanism of bovine trophoblast cells into placental component cells.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
Basic research for the development of therapeutic agents on endometriosis based upon senolytic regulation

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
A mechasism for bovine maternal immune tolerance toward pregnancy via sensing sperm and embryo

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2024
Investigation and application of bovine placental formation by intrauterine genome dynamics

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2024
Intrauterine environment during implantation in bovine pregnancy.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Sakurai Toshihiro
Investigation of assembly mechanism of placenta by retroelement

Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists, Grant-in-Aid for Early-Career Scientists, Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2020

Kusama Kazuya
Establishment and re-establishment of uterine environment for pregnancy success

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2020

Imakawa Kazuhiko
Maternal immune strategy to recognize conceptus in mammals

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Kusama Kazuya, IMAKAWA Kazuhiko

Profile Information

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Research History

Education

Awards

Papers

Misc.

Books and Other Publications

Major Professional Memberships

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