Norihiro Imai - My portal

Profile Information

Affiliation: Hospital, Department of Endoscopy, Nagoya University

Researcher number: 40877081
ORCID ID: https://orcid.org/0000-0002-5865-3245
J-GLOBAL ID: 202101020408966617
researchmap Member ID: R000018604

Awards

2019

American Heart Association Postdoctoral Fellowship, American Heart Association
2019

Best Poster Award, Postdoc Research Day, Weill Cornell Medicine, The Postdoctoral Association
2018

Irwin M. Arias, MD Postdoctoral Research Fellowship Award, American Liver Foundation
2015

Presidential Poster of Distinction, American Association for the Study of Liver Disease
2015

International Young Investigator Travel Award, American Association for the Study of Liver Disease
2015

Young Investigator Award of Nagoya University Internal Medicine
2015

2015 Best Poster Award, the 120th annual meeting of the Japanese Association of Anatomists, UBXD8 deletion in hepatocytes induced more evident abnormalities in female than in male mice, the 120th Annual Meeting of The Japanese Association of Anatomists, the 92nd Annual Meeting of The Physiological Society of Japan

Papers

Successful Treatment with Steroids in a Patient with Vanishing Bile Duct Syndrome and Acute Tubular Necrosis.

Fumitaka Mizuno, Norihiro Imai, Kazushi Yasuda, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Masatoshi Ishigami, Hiroki Kawashima

Internal medicine (Tokyo, Japan), 63(1) 57-61, Jan 1, 2024
Pretreatment Proteinuria Predicts the Prognosis of Patients Receiving Systemic Therapy for Unresectable Hepatocellular Carcinoma.

Kazuyuki Mizuno, Norihiro Imai, Takafumi Yamamoto, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Teiji Kuzuya, Masatoshi Ishigami …

Cancers, 15(10), May 21, 2023
Pretreatment Proteinuria Predicts the Prognosis of Patients Receiving Systemic Therapy for Unresectable Hepatocellular Carcinoma

Kazuyuki Mizuno, Norihiro Imai, Takafumi Yamamoto, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Teiji Kuzuya, Masatoshi Ishigami …

CANCERS, 15(10), May, 2023
Endoscopic injection sclerotherapy with polidocanol for cardiac varices in children and adolescents.

Shinya Yokoyama, Yoji Ishizu, Takashi Honda, Norihiro Imai, Takanori Ito, Kenta Yamamoto, Akinari Hinoki, Wataru Sumida, Chiyoe Shirota, Takahisa Tainaka …

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, Dec 9, 2022
Pipeline Esophagogastric Varices Secondary to Extrahepatic Portal Vein Obstruction Treated Endoscopically with the Assistance of Transileocolic Obliteration.

Shinya Yokoyama, Yoji Ishizu, Takashi Honda, Norihiro Imai, Takanori Ito, Kenta Yamamoto, Tomohiro Komada, Masamichi Hayashi, Masatoshi Ishigami

Internal medicine (Tokyo, Japan), 61(23) 3503-3511, Dec 1, 2022
Effectiveness of Porous Glass Membrane Pumping Emulsification Device in Transarterial Chemoembolization for Solitary Hepatocellular Carcinoma.

Norihiro Imai, Masatoshi Ishigami, Yumi Oie, Motoki Kumagai, Yosuke Inukai, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda …

Anticancer research, 42(8) 3947-3951, Aug, 2022
A case of antiprogrammed death-ligand 1 antibody-induced multisystem immune-related adverse events with pancreatitis and steroid-resistant sclerosing cholangitis.

Takafumi Yamamoto, Takanori Ito, Kazuyuki Mizuno, Yokoyama Shinya, Kenta Yamamoto, Norihiro Imai, Yoji Ishizu, Takashi Honda, Hiroki Kawashima, Toshinori Matsui …

Journal of digestive diseases, 23(7) 404-409, Jul, 2022
Changes in Body Composition Predict the Time to Treatment Failure of Lenvatinib in Patients with Advanced Hepatocellular Carcinoma: A Pilot Retrospective Study.

Takafumi Yamamoto, Norihiro Imai, Teiji Kuzuya, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Masatoshi Ishigami

Nutrition and cancer, 74(9) 1-10, Mar 12, 2022
Absence of large portal collateral vessels is associated with spontaneous improvement of cirrhotic portal vein thrombosis.

Shinya Yokoyama, Yoji Ishizu, Takashi Honda, Norihiro Imai, Takanori Ito, Kenta Yamamoto, Tomoyuki Tsuzuki, Masatoshi Ishigami

Hepatology research : the official journal of the Japan Society of Hepatology, 52(2) 199-209, Feb, 2022
Factors associated with the progression of myosteatosis in patients with cirrhosis.

Yoji Ishizu, Masatoshi Ishigami, Takashi Honda, Norihiro Imai, Takanori Ito, Kenta Yamamoto, Shinya Yokoyama, Tetsuya Ishikawa, Mitsuhiro Fujishiro

Nutrition (Burbank, Los Angeles County, Calif.), 103-104 111777-111777, 2022
Decreased appetite is associated with the presence of sarcopenia in patients with cirrhosis.

Yoji Ishizu, Masatoshi Ishigami, Takashi Honda, Norihiro Imai, Takanori Ito, Kenta Yamamoto, Shinya Yokoyama, Tetsuya Ishikawa, Hiroki Kawashima

Nutrition (Burbank, Los Angeles County, Calif.), 103-104 111807-111807, 2022
Obesity and myosteatosis: the two characteristics of dynapenia in patients with cirrhosis.

Yoshiaki Sugiyama, Yoji Ishizu, Yusuke Ando, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Norihiro Imai, Masanao Nakamura, Takashi Honda, Hiroki Kawashima …

European journal of gastroenterology & hepatology, 33(1S Suppl 1) e916-e921, Dec 1, 2021
Safety and Efficacy of Glass Membrane Pumping Emulsification Device in Transarterial Chemoembolization for Hepatocellular Carcinoma: First Clinical Outcomes.

Norihiro Imai, Shinya Yokoyama, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Masatoshi Ishigami

Anticancer research, 41(11) 5817-5820, Nov, 2021
Clinical course of liver injury induced by immune checkpoint inhibitors in patients with advanced malignancies.

Takanori Ito, Masatoshi Ishigami, Takafumi Yamamoto, Kazuyuki Mizuno, Kenta Yamamoto, Norihiro Imai, Yoji Ishizu, Takashi Honda, Hiroki Kawashima, Satoshi Yasuda …

Hepatology international, 15(5) 1278-1287, Aug 9, 2021
Tolerability of Molecular-targeted Agents for Hepatocellular Carcinoma Treatment in Haemophiliacs.

Takafumi Yamamoto, Norihiro Imai, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Shuichi Okamoto, Takeshi Kanematsu, Nobuaki Suzuki, Tadashi Matsushita …

Anticancer research, 41(5) 2569-2573, May, 2021
Impact of visceral fat accumulation on the prognosis of patients with cirrhosis.

Ishizu Y, Ishigami M, Honda T, Imai N, Ito T, Yamamoto K, Fujishiro M

Clinical nutrition ESPEN, 42 354-360, Apr, 2021
Progression After Molecular Targeted Agents: Hepatic Arterial Changes and Transarterial Chemoembolization in Hepatocellular Carcinoma.

Noritaka Matsuda, Norihiro Imai, Teiji Kuzuya, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Masatoshi Ishigami, Mitsuhiro Fujishiro

In vivo (Athens, Greece), 35(2) 1185-1189, Mar, 2021
Safety and efficacy of percutaneous radiofrequency ablation for hepatocellular carcinoma patients with haemophilia.

Takafumi Yamamoto, Norihiro Imai, Kenta Yamamoto, Takanori Ito, Yoji Ishizu, Takashi Honda, Shuichi Okamoto, Takeshi Kanematsu, Nobuaki Suzuki, Tadashi Matsushita …

Haemophilia : the official journal of the World Federation of Hemophilia, 27(1) 100-107, Jan, 2021
The albumin-bilirubin score as a predictor of outcomes in Japanese patients with PBC: an analysis using time-dependent ROC

Ito Takanori, Ishigami Masatoshi, Morooka Hikaru, Yamamoto Kenta, Imai Norihiro, Ishizu Yoji, Honda Takashi, Nishimura Daisaku, Tada Toshifumi, Yasuda Satoshi …

SCIENTIFIC REPORTS, 10(1) 17812, Oct 20, 2020
Allosteric regulation of thioesterase superfamily member 1 by lipid sensor domain binding fatty acids and lysophosphatidylcholine

Tillman Matthew C, Imai Norihiro, Li Yue, Khadka Manoj, Okafor C. Denise, Juneja Puneet, Adhiyaman Akshitha, Hagen Susan J, Cohen David E, Ortlund Eric A

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 117(36) 22080-22089, Sep 8, 2020

Misc.

Intermediate stageの進行肝細胞癌に対するソラフェニブの治療成績

葛谷貞二, 石上雅敏, 安藤祐資, 伊藤隆徳, 安田諭, 川口彩, 加藤幸一郎, 新家卓郎, 今井則博, 石津洋二 …

日本消化器病学会雑誌, 113(臨増総会) A352-A352, Mar, 2016
当院における肝細胞癌に対するマイクロバルーン閉塞下肝動脈化学塞栓療法(B-TACE)とConventional-TACEとの治療成績の比較

新家卓郎, 葛谷貞二, 安田諭, 川口彩, 加藤幸一郎, 今井則博, 阿知波宏一, 山田恵一, 石津洋二, 本多隆 …

肝臓, 56(Suppl.1) A528-A528, Apr, 2015
高齢者C型慢性肝炎におけるDaclatasvir/Asunaprevir併用療法の早期反応と治療効果

本多隆, 石上雅敏, 安藤祐資, 安田諭, 伊藤隆徳, 川口彩, 加藤幸一郎, 新家卓郎, 今井則博, 阿知波宏一 …

肝臓, 56(Supplement 3) A1046-A1046, 2015
進行肝細胞癌に対するソラフェニブ不応後TACEを組み合わせた症例の治療成績

葛谷貞二, 石上雅敏, 伊藤隆徳, 安田諭, 川口彩, 加藤幸一郎, 新家卓郎, 今井則博, 阿知波宏一, 石津洋二 …

日本消化器病学会大会(Web), 57th(臨増大会) A871-A871, 2015
CA19-9高値で見つかった進行肝細胞癌に対しソラフェニブが奏功した一例

安田諭, 葛谷貞二, 安藤祐資, 伊藤隆徳, 川口彩, 加藤幸一郎, 新家卓郎, 今井則博, 阿知波宏一, 石津洋二 …

肝臓, 56(Supplement 3) A1051-A1051, 2015
治療困難症例におけるV-Naviを駆使した確実かつ安全なRFA治療の工夫バブルが生じた後の針先端位置調節におけるVirtuTRAXの有用性に着目して

葛谷貞二, 新家卓郎, 加藤幸一郎, 今井則博, 阿知波宏一, 荒川恭宏, 山田恵一, 石津洋二, 本多隆, 林和彦 …

肝臓, 55(Suppl.1) A308-A308, Apr, 2014
コリン欠乏と閉経及びRaloxifeneによるNASH進展への影響

LUO F., 加藤幸一郎, 新家卓郎, 今井則博, 阿知波宏一, 荒川恭宏, 山田恵一, 石津洋二, 葛谷貞二, 本多隆 …

肝臓, 55(Supplement 2) A623-A623, 2014

Books and Other Publications

肝癌診療ハンドブックケースで学ぶ集学的治療のコツとセンス

今井則博, 池田健次 (Role: Joint author, ケースカンファレンス, 肝癌スクリーニングフローチャート, 各種モダリティの長所と短所, EOB-MRI肝細胞相でのみ低信号結節として指摘できる病変の診断, 肝動脈化学塞栓療法(TACE) 他)

南江堂, 2012
劇症肝炎, 病気がみえる vol. 1 消化器第4版

今井則博, 荒瀬康司 (Role: Joint author, 劇症肝炎)

メディックメディア, 2010

Presentations

SAFETY AND EFFICACY OF PERCUTANEOUS RADIOFREQUENCY ABLATION FOR HEPATOCELLULAR CARCINOMA PATIENTS WITH HEMOPHILIA

Yamamoto Takafumi, Ishigami Masatoshi, Yamamoto Kenta, Ito Takanori, Imai Norihiro, Lshizu Yoji, Honda Takashi, Fujishiro Mitsuhiro

HEPATOLOGY, Nov, 2020
MODELING NAFLD IN HIGH FAT FED MICE: IDENTIFICATION OF A THRESHOLD VALUE FOR HEPATIC STEATOSIS AND METABOLIC DYSFUNCTION

Imai Norihiro, Cohen David E

HEPATOLOGY, Nov, 2020
IMPROVEMENT OF LIVER FUNCTIONAL RESERVE AFTER SVR IN HCV-PATIENTS WITH COMPENSATED, SEVERE FIBROSIS BY IFN-FREE, DAA COMBINATION TREATMENT-IMPACT OF PRETREATMENT SERUM AFP LEVELS

Ishigami Masatoshi, Honda Takashi, Ishizu Yoji, Imai Norihiro, Ito Takanori, Yamamoto Kenta, Fujishiro Mitsuhiro

HEPATOLOGY, Nov, 2020
GUT MICROBIOTA ASSOCIATED WITH THE DIFFERENCE BETWEEN PATIENTS WITH AND WITHOUT HEPATOCELLULAR CARCINOMA IN CHRONIC LIVER DISEASE

Honda Takashi, Ishigami Masatoshi, Yamamoto Kenta, Ito Takanori, Imai Norihiro, Ishizu Yoji, Fujishiro Mitsuhiro

HEPATOLOGY, Nov, 2020
Thioesterase Superfamily Member 1 Undergoes Stimulus-coupled Reorganization to Regulate Metabolic Activity in Brown Adipose Tissue

Li Yue, Imai Norihiro, Goyal Samaksh, Nicholls Hayley, Krisko Tibor, Baqai Mahnoor, Ang Lay-Hong, Tillman Matthew, Ortlund Eric, Cohen David, Hagen Susan

FASEB JOURNAL, Apr, 2020
Them1 Binds to Free Fatty Acids and is Allosterically Regulated by Lysophosphatidylcholine to Control Fatty Acyl-CoA Hydrolysis in Brown Adipose Tissue

Tillman Matthew, Li Yue, Khadka Manoj, Imai Norihiro, Adhiyaman Akshitha, Juneja Puneet, Hagen Susan, Cohen David, Ortlund Eric

FASEB JOURNAL, Apr, 2020
SUPPRESSION OF FATTY ACID OXIDATION BY THIOESTERASE SUPERFAMILY MEMBER 2 IN SKELETAL MUSCLE PROMOTES HEPATIC STEATOSIS AND INSULIN RESISTANCE

Imai Norihiro, Alves-Bezerra Michele, Li Yingxia, Cohen David E

HEPATOLOGY
Muscle-Specific Metabolic Regulation By Thioesterase Superfamily Member 2 in the Pathogenesis of Nonalcoholic Fatty Liver Disease

Imai Norihiro, Cohen David E

HEPATOLOGY
Hepatocyte-Specific Depletion of Ubiquitin Regulatory X Domain-Containing 8 (UBXD8) Induces Marked Fibrosis in Mice Fed a Short-Term Non-Alcoholic Steatohepatitis (NASH) Model Diet

Imai Norihiro, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Hayashi Kazuhiko, Ishigami Masatoshi, Hirooka Yoshiki, Fujimoto Toyoshi, Goto Hidemi

HEPATOLOGY
Hepatocyte-specific depletion of UBXD8 accelerates fibrosis in a mouse non-alcoholic steatohepatitis model

Imai Norihiro, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Hayashi Kazuhiko, Ishigami Masatoshi, Hirooka Yoshiki, Fujimoto Toyoshi, Goto Hidemi

HEPATOLOGY
Hepatocyte-specific deletion of UBXD8 induces periportal steatosis after high-fat diet feeding

Imai Norihiro, Suzuki Michitaka, Ishizu Yoji, Kuzuya Teiji, Honda Takashi, Hayashi Kazuhiko, Ishigami Masatoshi, Fujimoto Toyoshi, Goto Hidemi

HEPATOLOGY

Professional Memberships

Research Projects

アルコール性肝障害におけるUBXD8機能の解明

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2021 - Mar, 2025

今井則博
臓器特異的なUBXD8の機能を主軸としたアルコール性肝障害の病態形成メカニズム

科学研究費助成事業, 国際共同研究加速基金(国際共同研究強化(A)), 日本学術振興会, 2022 - 2024

今井則博
Exploration of novel NAFLD therapeutic targets focusing on myokine-induced organ crosstalk

Grants-in-Aid for Scientific Research, Grant-in-Aid for Research Activity Start-up, Japan Society for the Promotion of Science, Sep, 2020 - Mar, 2022

Imai Norihiro