2007年3月
Fate determination of Drosophila leg distal regions by trachealess and tango through repression and stimulation, respectively, of Bar homeobox gene expression in the future pretarsus and tarsus
DEVELOPMENTAL BIOLOGY
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- ,
- ,
- ,
- 巻
- 303
- 号
- 2
- 開始ページ
- 461
- 終了ページ
- 473
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.ydbio.2006.11.026
- 出版者・発行元
- ACADEMIC PRESS INC ELSEVIER SCIENCE
During tissue patterning, developing fields may be subdivided into several non-overlapping domains by region-specific expression of transcription factors. In Drosophila leg development, the most distal segments, the pretarsus and tarsal segment 5 (ta5), are precisely specified by interactions between tarsus bomeobox genes (BarH1 and BarH2) and pretarsus homeobox genes (aristaless, clawless, and Lim1). Here, we demonstrate that trachealess and tango, both encoding bHLH-PAS proteins that are required for the formation of the embryonic tracheal system, are essential for forming two adjacent distal segments of the leg. trachealess is expressed in the pretarsus and ta5, and the concerted action of trachealess and tango seems to modulate the activity of bomeobox gene regulatory loops by repressing Bar in the pretarsus and activating Bar in ta5. (c) 2006 Elsevier Inc. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.ydbio.2006.11.026
- ISSN : 0012-1606
- PubMed ID : 17187773
- Web of Science ID : WOS:000244991500005