We fabricated three-dimensional (3D) core-shell microneedle-electrode array for recording neuronal activities in the brain tissue. Advantage of embedding core-shell electrode in individual microneedle include i) multisite recording, ii) simultaneous stimulation, and iii) high signal to noise ratio (SNR) recording by grounding the shell electrode. This paper demonstrates the first advantage of the multisite neuronal recording using mouse brain tissue in vivo.