2016年12月
Relationship between the grades of a learned aversive-feeding response and the dopamine contents in Lymnaea
BIOLOGY OPEN
- ,
- ,
- ,
- ,
- ,
- 巻
- 5
- 号
- 12
- 開始ページ
- 1869
- 終了ページ
- 1873
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1242/bio.021634
- 出版者・発行元
- COMPANY OF BIOLOGISTS LTD
The pond snail Lymnaea learns conditioned taste aversion (CTA) and remembers not to respond to food substances that initially cause a feeding response. The possible relationship between how well snails learn to follow taste-aversion training and brain dopamine contents is not known. We examined this relationship and found the following: first, snails in the act of eating just before the commencement of CTA training were poor learners and had the highest dopamine contents in the brain; second, snails which had an ad libitum access to food, but were not eating just before training, were average learners and had lower dopamine contents; third, snails food-deprived for one day before training were the best learners and had significantly lower contents of dopamine compared to the previous two cohorts. There was a negative correlation between the CTA grades and the brain dopamine contents in these three cohorts. Fourth, snails food-deprived for five days before training were poor learners and had higher dopamine contents. Thus, severe hunger increased the dopamine content in the brain. Because dopamine functions as a reward transmitter, CTA in the severely deprived snails (i.e. the fourth cohort) was thought to be mitigated by a high dopamine content.
- リンク情報
- ID情報
-
- DOI : 10.1242/bio.021634
- ISSN : 2046-6390
- PubMed ID : 27815244
- Web of Science ID : WOS:000391276200013