2019年9月3日
Photosensitizer and anticancer drug-loaded 2D nanosheet: Preparation, stability and anticancer property
2D Materials
- 巻
- 6
- 号
- 4
- 開始ページ
- 045035
- 終了ページ
- 045035
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1088/2053-1583/ab377b
- 出版者・発行元
- IOP Publishing
Cancer phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT) has attracted extensive interest due to its non-invasive and region-specific nature. In order to enhance the efficacy, we have fabricated various nanocomposites consisting of a photosensitizer (chlorin e 6 (Ce6), pheophorbide a (Pa) or bacteriopheophorbide a (bPa)) for PDT and a two-dimensional nanosheet (graphene or MoS2) for PTT by a one-pot protocol through liquid phase exfoliation. In addition, an anticancer drug (doxorubicin (DOX) or irinotecan (Ir)) was loaded on the nanosheet in the same way for comparison. The nanocomposites demonstrated stability when dispersed in water except for MoS2-Ir. We observed that MoS2-Ce6 killed cancer cells over ten times more effectively than other Ce6-loaded nanocomposites.
- リンク情報
-
- DOI
- https://doi.org/10.1088/2053-1583/ab377b
- URL
- https://iopscience.iop.org/article/10.1088/2053-1583/ab377b
- URL
- https://iopscience.iop.org/article/10.1088/2053-1583/ab377b/pdf
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85081982546&origin=inward
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85081982546&origin=inward
- ID情報
-
- DOI : 10.1088/2053-1583/ab377b
- eISSN : 2053-1583
- SCOPUS ID : 85081982546