2014年10月
Cortical Representations Are Reinstated by the Hippocampus during Memory Retrieval
NEURON
- ,
- ,
- ,
- ,
- ,
- 巻
- 84
- 号
- 2
- 開始ページ
- 347
- 終了ページ
- 354
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.neuron.2014.09.037
- 出版者・発行元
- CELL PRESS
The hippocampus is assumed to retrieve memory by reinstating patterns of cortical activity that were observed during learning. To test this idea, we monitored the activity of individual cortical neurons while simultaneously inactivating the hippocampus. Neurons that were active during context fear conditioning were tagged with the long-lasting fluorescent protein H2B-GFP and the light-activated proton pump ArchT. These proteins allowed us to identify encoding neurons several days after learning and silence them with laser stimulation. When tagged CA1 cells were silenced, we found that memory retrieval was impaired and representations in the cortex (entorhinal, retrosplenial, perirhinal) and the amygdala could not be reactivated. Importantly, hippocampal inactivation did not alter the total amount of activity in most brain regions. Instead, it selectively prevented neurons that were active during learning from being reactivated during retrieval. These data provide functional evidence that the hippocampus reactivates specific memory representations during retrieval.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.neuron.2014.09.037
- ISSN : 0896-6273
- eISSN : 1097-4199
- PubMed ID : 25308331
- Web of Science ID : WOS:000344167900014