Yoshiyuki Adachi

Profile Information

Affiliation: School of Pharmacy School of Pharmacy, Tokyo University of Pharmacy and Life Sciences

Degree: (BLANK)

J-GLOBAL ID: 200901077359625740
researchmap Member ID: 1000081483

External link: https://www.ps.toyaku.ac.jp/menekigaku/

Research Interests

Research Areas

Papers

219

Polymeric Caffeic Acid Acts as an Antigen Delivery Carrier for Mucosal Vaccine Formulation by Forming a Complex with an Antigenic Protein

Rui Tada, Yuzuho Nagai, Miki Ogasawara, Momoko Saito, Akihiro Ohshima, Daisuke Yamanaka, Jun Kunisawa, Yoshiyuki Adachi, Yoichi Negishi

Vaccines, 12(5) 449-449, Apr 23, 2024
High-parameter immune profiling and subjective health assessment of the immunomodulatory effects of paramylon-rich Euglena gracilis EOD-1: A randomized, double-blind, placebo-controlled, parallel-group study

Takanori Kawano, Atsushi Miura, Junko Naito, Norihisa Nishida, Ken-ichi Ishibashi, Yoshiyuki Adachi, Naohito Ohno, Yuji Naito

Journal of Functional Foods, 109 105804-105804, Oct, 2023 Peer-reviewed
アレルゲン・抗原カモガヤ花粉β-1,3-D-glucanの局在と免疫活性に関する研究

菅野峻史, 山口明莉, 平塚理恵, 安達禎之

アレルギー, 72(6-7) 901-901, Aug, 2023
Refinement and complete solution NMR analysis of the structure of a 6-branched 1,3-β-D-glucan (OL-2) isolate from Omphalia lapidescens

Rui Tada, Naohito Ohno, Yoshiyuki Adachi

Carbohydrate Research, 108849-108849, May, 2023 Peer-reviewedLast author
Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression.

Ce Tang, Haiyang Sun, Motohiko Kadoki, Wei Han, Xiaoqi Ye, Yulia Makusheva, Jianping Deng, Bingbing Feng, Ding Qiu, Ying Tan …

Nature communications, 14(1) 1493-1493, Mar 17, 2023 Peer-reviewed
Potentiation of antitumor activity by antibody drugs and mushroom-derived β-glucans in natural killer cell-mediated tumoricidal activities against non-Hodgkin&apos;s B-cell lymphoma

Yoshiyuki Adachi, Fumiyasu Momose, Hiromi Momose, Rui Tada, Naohito Ohno

International Journal of Medicinal Mushrooms, 25(3) 1-19, Mar, 2023 Peer-reviewedLead authorCorresponding author
Binding assay of human Dectin-1 variants for DNA/ β-glucan complex for active-targeting delivery of antisense DNA: Part II.

Kazuki Sumiya, Hiroto Izumi, Yoshiyuki Adachi, Shinichi Mochizuki, Kazuo Sakurai

Carbohydrate research, 523 108731-108731, Jan, 2023 Peer-reviewed
Dectin-1 Reactivity to Paramylon Derived from Euglena gracilis EOD-1.

Ken-Ichi Ishibashi, Nobuteru Onaka, Norihisa Nishida, Madoka Takahashi, Yoshiyuki Adachi, Naohito Ohno

Biological & pharmaceutical bulletin, 45(9) 1394-1397, Sep 1, 2022 Peer-reviewed
アレルゲン・抗原・免疫療法・検査法カモガヤ花粉β-1,3-D-glucanの局在と免疫活性に関する研究

菅野峻史, 山口明莉, 平塚理恵, 岩倉洋一郎, 山中大輔, 安達禎之

アレルギー, 71(6-7) 795-795, Aug, 2022
Functionally modified chitotriosidase catalytic domain for chitin detection based on split-luciferase complementation.

Daisuke Yamanaka, Kento Suzuki, Masahiro Kimura, Fumitaka Oyama, Yoshiyuki Adachi

Carbohydrate polymers, 282 119125-119125, Apr 15, 2022
Jerveratrum-Type Steroidal Alkaloids Inhibit β-1,6-Glucan Biosynthesis in Fungal Cell Walls.

Karen Kubo, Kaori Itto-Nakama, Shinsuke Ohnuki, Yoko Yashiroda, Sheena C Li, Hiromi Kimura, Yumi Kawamura, Yasuhiro Shimamoto, Ken-Ichi Tominaga, Daisuke Yamanaka …

Microbiology spectrum, 10(1) e0087321, Feb 23, 2022
Recombinant Human Soluble Thrombomodulin Suppresses Arteritis in a Mouse Model of Kawasaki Disease.

Hironobu Nakayama, Hiroyasu Inada, Tatsuya Inukai, Kenta Kondo, Kazuyuki Hirai, Tomonari Tsutsumi, Yoshiyuki Adachi, Noriko Nagi-Miura, Naohito Ohno, Koji Suzuki

Journal of vascular research, 59(3) 1-13, Dec 20, 2021
Diagnostic Challenge and Therapeutic Approaches in Human Sepsis Based on the Appearance of Endotoxemia and Beta-d-Glucanemia

Hiroshi Tamura, Yoshiyuki Adachi

International Journal of Molecular Sciences, Nov 29, 2021 Peer-reviewedCorresponding author
未病と抗老化(Vol.30:81-87) 露地栽培アガリクスKA21株のヒト臨床への応用免疫増強、真菌感染症予防、創傷治癒、育毛作用

元井章智, 元井里奈, 元井益郎, 北原淳子, 元井美貴, 田島克哉, 山中大輔, 安達禎之, 大野尚仁

未病と抗老化, 30 82-87, Nov, 2021
リムルスGテスト擬陽性反応におけるスギ花粉の影響

菅野峻史, 山中大輔, 石橋健一, 大野尚仁, 安達禎之

日本医真菌学会雑誌, 62(Suppl.1) 108-108, Oct, 2021
スギ花粉の自然免疫刺激活性における藻類由来水溶性β-1,3-D-glucanの抑制作用

菅野峻史, 金チャンミン, 大野尚仁, 岩倉洋一郎, 安達禎之

アレルギー, 70(6-7) 876-876, Aug, 2021
Development of a Highly Sensitive β-Glucan Detection System Using Scanning Single-Molecule Counting Method

Yoshiyuki Adachi, Hidetaka Nakata, Tetsuya Tanabe, Daisuke Yamanaka, Takashi Kanno, Ken-ichi Ishibashi, Naohito Ohno

International Journal of Molecular Sciences, 22(11), Jun 1, 2021 Peer-reviewedLead authorCorresponding author
Polymeric Caffeic Acid Acts as a Nasal Vaccine Formulation against Streptococcus pneumoniae Infections in Mice

Rui Tada, Hidehiko Suzuki, Miki Ogasawara, Daisuke Yamanaka, Yoshiyuki Adachi, Jun Kunisawa, Yoichi Negishi

Pharmaceutics, 13(4), Apr 20, 2021 Peer-reviewed
Binding Specificity of a New Artificial β-Glucan Recognition Protein and Its Application to β-Glucan Detection in Mushroom Extracts

Yoshiyuki Adachi, Takashi Kanno, Ken-ichi Ishibashi, Daisuke Yamanaka, Akitomo Motoi, Masuro Motoi, Naohito Ohno

International Journal of Medicinal Mushrooms, 23(4) 1-12, Apr, 2021 Peer-reviewedLead authorCorresponding author
β-1,6-グルカナーゼの機能改変による高感度β-1,6-グルカン測定法と応用

山中大輔, 後藤佳世, 中島大智, 木村将大, 小山文隆, 大野尚仁, 安達禎之

日本薬学会年会要旨集, 141年会 27P02-086, Mar, 2021

Misc.

303

Comparison of various pollen species in Dectin-1 dependent immune activation

菅野峻史, 山口明莉, 平塚理恵, 岩倉洋一郎, 山中大輔, 安達禎之

日本生体防御学会学術総会講演抄録集, 33rd, 2022
Development of novel structure-specific detection method for β-1,3/1,6-glucan using split-NanoLuc-fused β-glucan binding proteins

山中大輔, 栗田涼香, 菅野峻史, 安達禎之

日本薬学会年会要旨集(Web), 142nd, 2022
Comparison of mouse strains in the reactivity to β-1,3-D-glucan in Cryptomeria japonica pollen.

滝田峻也, 菅野峻史, 山中大輔, 安達禎之

日本薬学会年会要旨集(Web), 142nd, 2022
Evaluation of novel mouse Dectin-1 neutralizing antibodies

齋藤航, 菅野峻史, 前田直樹, 山中大輔, 安達禎之

日本薬学会年会要旨集(Web), 142nd, 2022
Investigation of purification methods of b-1,3-D-glucan Cryptomeria japonica pollen

田中愛美, 坂西みさと, 菅野峻史, 山中大輔, 安達禎之

日本薬学会年会要旨集(Web), 142nd, 2022
Comparison of the innate immunoactivity of b-1,3-D-glucan in pollen from various plants.

山口明莉, 菅野峻史, 山中大輔, 安達禎之

日本薬学会年会要旨集(Web), 142nd, 2022
Studies on the organ distribution of β-1,6-glucan

小林茉鈴, 山中大輔, 杉浦真裕, 菅野峻史, 元井章智, 元井章智, 安達禎之

日本薬学会年会要旨集(Web), 142nd, 2022
The immunoactivities of β-1,3-D-glucan in Chamaecyparis obtusa pollen.

岡野笑帆, 渡辺大貴, 菅野峻史, 山中大輔, 安達禎之

日本薬学会年会要旨集(Web), 142nd, 2022
Effect of β-1,6-glucan branches on Dectin-1 activation by Zymosan

川島理生, 山中大輔, 栗田涼香, 菅野峻史, 安達禎之

日本薬学会年会要旨集(Web), 142nd, 2022
露地栽培アガリクスKA21株のヒト臨床への応用 : 免疫増強、真菌感染症予防、創傷治癒、育毛作用

元井章智, 元井里奈, 元井益郎, 北原淳子, 元井美貴, 田島克哉, 山中大輔, 安達禎之, 大野尚仁

30 82-87, Nov, 2021
Inhibitory effect of algae β-glucan on Japanese cedar pollen-stimulated dendritic cell activation

菅野峻史, KIM Changmin, 岩倉洋一郎, 大野尚仁, 安達禎之

日本生体防御学会学術総会講演抄録集, 32nd, 2021
スプリットルシフェラーゼ融合β-グルカン認識タンパク質を用いた真菌細胞壁の糖鎖構造解析

山中大輔, 菅野峻史, 安達禎之

日本医真菌学会雑誌, 62(Supplement 1), 2021
川崎病モデルマウスを用いた組換トロンボモジュリンの治療効果の検討

近藤健太, 近藤健太, 中山浩伸, 伊奈田宏康, 犬飼達也, 平井一行, 堤智斉, 三浦典子, 安達禎之, 大野尚仁 …

微生物シンポジウム講演要旨集, 33rd, 2021
Identification of core fucose containing N-glycan recognition lectin.

真鍋良幸, 真鍋良幸, MARCHETTI Roberta, 高倉陽平, 長崎政裕, 二瓶渉, 武部智之, 田中克典, 田中克典, 樺山一哉 …

日本糖質学会年会要旨集, 39th, 2020
Latent 1,3-β-glucan of cedar pollen acts as an adjuvant for allergen-specific immunoglobulin production.

菅野峻史, 安達禎之, 土井雅津代, 松原弘季, 平塚理恵, 岩倉洋一郎, 山中大輔, 石橋健一, 大野尚仁

日本生体防御学会学術総会講演抄録集, 30th, 2019
β-mannan合成酵素欠損株C.albicans由来mannoprotein画分の生物活性の検討

川村誉, 石橋健一, 山中大輔, 安達禎之, 大野尚仁

日本薬学会年会要旨集, 137年会(3) 172-172, Mar, 2017
C.albicans菌糸型及び酵母型由来β-glucanの食細胞に対する生物活性の比較検討

田原清美, 石橋健一, 山中大輔, 安達禎之, 大野尚仁

日本薬学会年会要旨集, 137年会(3) 172-172, Mar, 2017
Aspergillus細胞壁α-1,3-glucanの白血球活性化作用の検討

佐藤恵理子, 石橋健一, 山中大輔, 安達禎之, 大野尚仁

日本薬学会年会要旨集, 137年会(3) 172-172, Mar, 2017
Aspergillus細胞壁α-1,3-glucan投与マウスの炎症反応誘発作用の検討

中嶋唯, 石橋健一, 山中大輔, 安達禎之, 大野尚仁

日本薬学会年会要旨集, 137年会(3) 172-172, Mar, 2017
発酵霊芝の内因性敗血症モデルマウスに対する影響について

石本由維菜, 石橋健一, 山中大輔, 安達禎之, 位上健太郎, 伊藤久富, 大野尚仁

日本薬学会年会要旨集, 137年会(3) 173-173, Mar, 2017

Books and Other Publications

新しい微生物学

大野, 尚仁, 野口, 雅久, 笹津, 備規, 安達, 禎之

廣川書店, Mar, 2016 (ISBN: 9784567520577)
免疫学概説

宿前, 利郎, 大野, 尚仁, 安達, 禎之, 三浦, 典子, 石橋, 健一

廣川書店, Aug, 2010 (ISBN: 9784567534222)
内因性敗血症モデルにおける肝不全発症機構の解析

大野, 尚仁, 安達, 禎之, 三浦, 典子, 滑田, 祥子

[大野尚仁], 2006
抗腫瘍性(1→3)-β-D-グルカン及びその誘導体の構造と免疫学的諸活性との相関性に関する研究

安達, 禎之

[安達禎之], 1990

Professional Memberships

Research Projects

Structural profiling of fungal cell wall polysaccharides using functionally modified glycoside hydrolase

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2027
Application of drug discovery based on immunoreceptor-mediated regulation of osteoclastogenesis by glucan

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2026
スギ花粉β-グルカンの免疫学的緒活性とアレルギー疾患との関連性に関する研究

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

安達禎之
スギ花粉多糖成分によるアジュバント活性の解析

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2018 - Mar, 2021

大野尚仁, 安達禎之
スギ花粉内在性免疫アジュバントの解析

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2018 - Mar, 2021

安達禎之
The synthesis of biologically active oligosaccharides in symbiosis and immunity

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2014

TANAKA Hiroshi, JINMO Mitsuru, YAMAGUCHI Yoshiki, KAWAUCHI Susumu, ADACHI Yoshiyuki
Characterization of immunotoxicological and immunopathological roles of fungal PAMPs

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

OHNO Naohito
Examination of rapid and easy detection methods for fungal beta-glucans

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2010 - 2012

ADACHI Yoshiyuki, OHNO Naohito, MIURA Noriko, ISHIBASHI Ken-ichi
Characterization of dermal allergic murine models induce by repeated application of non protein substance from pathogenic fungi.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2009

ADACHI Yoshiyuki, OHNO Naohito, MIURA Noriko
真菌PAMPsによる消化管粘膜バリア機能の損傷機構に関する研究

科学研究費助成事業挑戦的萌芽研究, 挑戦的萌芽研究, 日本学術振興会, 2007 - 2009

大野尚仁, 安達禎之, 三浦典子
The mechanism of liver dysfunction in endogenous septic shock model mice

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2003 - 2005

OHNO Naohito, ADACHI Yoshiyuki, MIURA Noriko, NAMEDA Sachiko
細胞内NADPHの蛍光振幅変化を指標にした白血球の活性化機構の解析

科学研究費助成事業奨励研究(A), 奨励研究(A), 日本学術振興会, 2000 - 2001

安達禎之
Study on regulation of inflammatory response by new mooclonal antibody against leukocytes.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 1998 - 1999

YADOMAE Toshiro, ADACHI Yoshiyuki, OHNO Naohito
β-D-グルカンの免疫薬理効果に関する研究
Study on immunopharmacological effect of β-D-glucans

Industrial Property Rights

特願2019-209679 β-1,3-1,6-グルカンの測定方法

中田秀孝, 安達禎之, 石橋健一, 山中大輔, 大野尚仁
特願2019-107248 β-グルカン結合タンパク質、β-グルカン検出キット、人工DNAおよび細菌

安達禎之, 大野尚仁, 元井益郎, 元井章智
特願2001-264921 アルペルギルス由来グルカン

大野尚仁、安達禎之、三浦典子、田村弘志、小倉紀彦
特開2000-86699 細胞表面抗原CD14を認識する新規なモノクローナル抗体

安達禎之, 大野尚仁, 宿前利郎
WO2006/051632 抗デクチン－１モノクローナル抗体を産生するハイブリドーマ

安達禎之、大野尚仁
特願2006-204497 脱顆粒促進剤及び脱顆粒抑制物質の評価方法

大野尚仁、安達禎之、田村弘志

Media Coverage

花粉内アジュバント解明‐スギ花粉症の発症に関与

株式会社薬事日報社, 薬事日報, https://www.yakuji.co.jp/entry81930.html, Oct 7, 2020 Newspaper, magazine

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