2011年5月
Subclinical Brain Injury Caused by H5N1 Influenza Virus Infection
JOURNAL OF VIROLOGY
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 85
- 号
- 10
- 開始ページ
- 5202
- 終了ページ
- 5207
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1128/JVI.00239-11
- 出版者・発行元
- AMER SOC MICROBIOLOGY
Although H5N1 influenza A viruses can cause systemic infection, their neurotropism and long-term effects on the central nervous system (CNS) are not fully understood. We assessed H5N1viral invasion of the CNS and its long-term effects in a ferret model. An H5N1 virus caused nonsuppurative encephalitis, which lasted for 3 months without neurologic signs. Further, another H5N1 virus caused nonsuppurative vasculitis with brain hemorrhage. Three-dimensional analysis of viral distribution in the brain identified the olfactory system as a major route for brain invasion. The efficient growth of virus in the upper respiratory tract may thus facilitate viral brain invasion.
- リンク情報
- ID情報
-
- DOI : 10.1128/JVI.00239-11
- ISSN : 0022-538X
- PubMed ID : 21389133
- Web of Science ID : WOS:000289787300054