2014年7月
Effect of Lipid Amount on Surfactant-free Solid Lipid Nanoparticle Formation by Hot Homogenization
CHEMISTRY LETTERS
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- 巻
- 43
- 号
- 7
- 開始ページ
- 1011
- 終了ページ
- 1013
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1246/cl.140279
- 出版者・発行元
- CHEMICAL SOC JAPAN
The yield and size distribution of surfactant-free solid lipid nanoparticles (SF-SLNs) formed by hot homogenization were investigated by changing the amount of lipid (palmitic acid). The yield was 100% and monodispersed same-sized particles of 120-200 nm were formed at the lipid amount <= 2.8 x 10(-4) g-lipid (g-water)(-1). The yield decreased owing to phase separation, and the size increased "step-likely" to be 200 350 nm while keeping the monodispersity when the lipid amount was just above <= 2.8 x 10(-4) g-lipid (g-water)(-1). The size and the lipid amount continued to increase gradually at the lipid amount >2.8 x 10(-4) g-lipid (g-water)(-1). The results indicate that submicron-sized solid lipid particles can be formed without surfactants and that the decrease of yield and the step-like increase of particle size occur at the same lipid amount. The total surface area of the SF-SLNs was estimated using the experimental data. It is suggested that the total surface area and the lipid amount are correlated to each other.
- リンク情報
- ID情報
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- DOI : 10.1246/cl.140279
- ISSN : 0366-7022
- eISSN : 1348-0715
- Web of Science ID : WOS:000339364800015