2016年9月
Elevated pentraxin 3 level at the early stage of exercise training is associated with reduction of arterial stiffness in middle-aged and older adults
Journal of Human Hypertension
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- 巻
- 30
- 号
- 9
- 開始ページ
- 521
- 終了ページ
- 526
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/jhh.2015.105
- 出版者・発行元
- Springer Science and Business Media LLC
Regular exercise improves aging-induced deterioration of arterial stiffness, and is associated with elevated production of pentraxin 3 (PTX3) and anti-inflammatory as well as anti-Atherosclerotic effects. However, the time-dependent effect of exercise training on arterial stiffness and PTX3 production remains unclear. The purpose of this study was to investigate the time course of the association between the effects of training on the circulating PTX3 level and arterial stiffness in middle-Aged and older adults. Thirty-Two healthy Japanese subjects (66.2±1.3 year) were randomly divided into two groups: Training (exercise intervention) and sedentary controls. Subjects in the training group completed 8 weeks of aerobic exercise training (60-70% peak oxygen uptake (VO 2peak) for 45 min, 3 days per week); during the training period, we evaluated plasma PTX3 concentration and carotid-femoral pulse wave velocity (cfPWV) every 2 wk. cfPWV gradually declined over the 8-week training period, and was significantly reduced after 6 and 8 week of exercise intervention (P<0.05). Plasma PTX3 level was significantly increased after 4 weeks of the intervention (P<0.05). In addition, the exercise training-induced reduction in cfPWV was negatively correlated with the percent change in plasma PTX3 level after 6 week (r=-0.54, P<0.05) and 8 weeks (r=-0.51, P<0.05) of the intervention, but not correlated at 4 weeks. Plasma PTX3 level was elevated at the early stage of the exercise training intervention, and was subsequently associated with training-induced alteration of arterial stiffness in middle-Aged and older adults.
- リンク情報
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- DOI
- https://doi.org/10.1038/jhh.2015.105
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/26467819
- URL
- http://www.nature.com/articles/jhh2015105.pdf
- URL
- http://www.nature.com/articles/jhh2015105
- Scopus
- https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84944128772&origin=inward 本文へのリンクあり
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=84944128772&origin=inward
- ID情報
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- DOI : 10.1038/jhh.2015.105
- ISSN : 0950-9240
- eISSN : 1476-5527
- PubMed ID : 26467819
- SCOPUS ID : 84944128772