2018年6月11日
Multi-ethnic genome-wide association study for atrial fibrillation.
Nature genetics
- 巻
- 50
- 号
- 9
- 開始ページ
- 1225
- 終了ページ
- 1233
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/s41588-018-0133-9
- 出版者・発行元
- Nature Publishing Group
Atrial fibrillation (AF) affects more than 33 million individuals worldwide1 and has a complex heritability2. We conducted the largest meta-analysis of genome-wide association studies (GWAS) for AF to date, consisting of more than half a million individuals, including 65,446 with AF. In total, we identified 97 loci significantly associated with AF, including 67 that were novel in a combined-ancestry analysis, and 3 that were novel in a European-specific analysis. We sought to identify AF-associated genes at the GWAS loci by performing RNA-sequencing and expression quantitative trait locus analyses in 101 left atrial samples, the most relevant tissue for AF. We also performed transcriptome-wide analyses that identified 57 AF-associated genes, 42 of which overlap with GWAS loci. The identified loci implicate genes enriched within cardiac developmental, electrophysiological, contractile and structural pathways. These results extend our understanding of the biological pathways underlying AF and may facilitate the development of therapeutics for AF.
- リンク情報
- ID情報
-
- DOI : 10.1038/s41588-018-0133-9
- ISSN : 1546-1718
- ISSN : 1061-4036
- PubMed ID : 29892015
- PubMed Central 記事ID : PMC6136836
- SCOPUS ID : 85048317620