2018年9月
Liver stiffness and arterial stiffness/abnormal central hemodynamics in the early stage of heart failure.
International journal of cardiology. Heart & vasculature
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- 巻
- 20
- 号
- 開始ページ
- 32
- 終了ページ
- 37
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.ijcha.2018.07.001
- 出版者・発行元
- (一社)日本循環器学会
BACKGROUND: It remains to be clarified whether liver stiffness is a direct risk factor for heart failure (HF) or whether its association with HF is mediated by vascular damage. We conducted cross-sectional and prospective longitudinal studies to examine whether fibrosis 4 score (FIB-4 score) is directly associated with the serum NT-pro-BNP levels or the association is mediated by arterial stiffness and/or abnormal central hemodynamics. METHODS AND RESULTS: In 3040 health Japanese subjects with serum NT-pro-BNP levels < 125 pg/ml, the FIB-4 score was calculated, and the serum NT-pro-BNP levels, brachial-ankle pulse wave (baPWV) velocity and radial augmentation index (rAI) were measured. These parameters were measured again after a 3-year interval in 2135 subjects. Multivariate linear regression analysis demonstrated a significant cross-sectional association of the FIB-4 scores with the log-transformed the serum NT-pro-BNP levels (beta = 0.08, p < 0.01), but not with the baPWV or rAI. The change of serum NT-pro BNP levels during the study period was significantly higher in subjects with increase of the FIB-4 score during the study period (8.2 ± 22.5 pg/ml) than that in those with decrease/no change (5.4 ± 22.3 pg/ml) (p < 0.05). CONCLUSION: Liver stiffness may have a significant direct association with the development of HF from the early stage, without the mediation of arterial stiffness and/or abnormal central hemodynamics. Therefore, the FIB-4 score appears to serve as a direct risk factor for HF from the early stage, and its association with HF may not be mediated by vascular damages.
- リンク情報
- ID情報
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- DOI : 10.1016/j.ijcha.2018.07.001
- 医中誌Web ID : 2020001398
- PubMed ID : 30094333
- PubMed Central 記事ID : PMC6076211