2017年11月
Lattice system of functionally distinct cell types in the neocortex
SCIENCE
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回数 : 4
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- 巻
- 358
- 号
- 6363
- 開始ページ
- 610
- 終了ページ
- 615
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1126/science.aam6125
- 出版者・発行元
- AMER ASSOC ADVANCEMENT SCIENCE
The mammalian neocortex contains many cell types, but whether they organize into repeated structures has been unclear. We discovered that major cell types in neocortical layer 5 form a lattice structure in many brain areas. Large-scale three-dimensional imaging revealed that distinct types of excitatory and inhibitory neurons form cell type-specific radial clusters termed microcolumns. Thousands of microcolumns, in turn, are patterned into a hexagonal mosaic tessellating diverse regions of the neocortex. Microcolumn neurons demonstrate synchronized in vivo activity and visual responses with similar orientation preference and ocular dominance. In early postnatal development, microcolumns are coupled by cell type-specific gap junctions and later serve as hubs for convergent synaptic inputs. Thus, layer 5 neurons organize into a brainwide modular system, providing a template for cortical processing.
- リンク情報
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- DOI
- https://doi.org/10.1126/science.aam6125 本文へのリンクあり
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/29097542
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000414240500029&DestApp=WOS_CPL
- URL
- https://www.science.org/doi/10.1126/science.aam6125
- ID情報
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- DOI : 10.1126/science.aam6125
- ISSN : 0036-8075
- eISSN : 1095-9203
- PubMed ID : 29097542
- Web of Science ID : WOS:000414240500029