Cyclists are frequently injured head and lower extremities in car-to-cyclist collisions. In this research, kinematic behavior of the whole body and the interaction of car, cyclist and bicycle were numerically investigated using a simulation with an FE simulation. Kinematic behavior of a cyclist was similar to that of a pedestrian, but the pelvis and head movement were different due to difference of posture of the lower extremities. Cyclist's tibia impacted to hood leading edge and shear loading was applied in the cyclist's knee, which can cause knee injury.