Apr, 2005
Involvement of Saccharomyces cerevisiae Pdr5p ATP-binding cassette transporter in calcium homeostasis
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
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- Volume
- 69
- Number
- 4
- First page
- 857
- Last page
- 860
- Language
- English
- Publishing type
- Research paper (scientific journal)
- Publisher
- TAYLOR & FRANCIS LTD
Deletion of PDR5 gene (Delta pdr5) in Saccharomyces cerevisiae led to increased resistance to calcium. The cellular Ca2+ level in the presence of high calcium as estimated by reporter assay in Delta pdr5 cells was significantly lower than that in wild-type cells. Membrane Pdr5p levels diminished rapidly during incubation with high calcium in a manner dependent on calcineurin and Pep4p, suggesting a feedback regulatory mechanism for Pdr5p abundance.
- Link information
- ID information
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- ISSN : 0916-8451
- eISSN : 1347-6947
- Web of Science ID : WOS:000228915700030