2013年12月
A rheostat for immune responses: The unique properties of PD-1 and their advantages for clinical application
Nature Immunology
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- 巻
- 14
- 号
- 12
- 開始ページ
- 1212
- 終了ページ
- 1218
- 記述言語
- 英語
- 掲載種別
- 書評論文,書評,文献紹介等
- DOI
- 10.1038/ni.2762
- 出版者・発行元
- Nature Publishing Group
PD-1, a negative coreceptor expressed on antigen-stimulated T cells and B cells, seems to serve as a 'rheostat' of the immune response. The molecular mechanisms of the functions of PD-1, in conjunction with the mild, chronic and strain-specific autoimmune phenotypes of PD-1-deficient mice, in contrast to the devastating fatal autoimmune disease of mice deficient in the immunomodulatory receptor CTLA-4, suggest that immunoregulation by PD-1 is rather antigen specific and is mainly cell intrinsic. Such unique properties make PD-1 a powerful target for immunological therapy, with highly effective clinical applications for cancer treatment. © 2013 Nature America, Inc.
- リンク情報
- ID情報
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- DOI : 10.1038/ni.2762
- ISSN : 1529-2908
- ISSN : 1529-2916
- CiNii Articles ID : 120005527992
- identifiers.cinii_nr_id : 9000277057734
- PubMed ID : 24240160
- SCOPUS ID : 84887862839