2006年10月
Regulation of B1 cell migration by signals through Toll-like receptors
JOURNAL OF EXPERIMENTAL MEDICINE
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- 巻
- 203
- 号
- 11
- 開始ページ
- 2541
- 終了ページ
- 2550
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1084/jem.20061041
- 出版者・発行元
- ROCKEFELLER UNIV PRESS
Peritoneal B1 cells are known to generate large amounts of antibodies outside their residential site. These antibodies play an important role in the early defense against bacteria and viruses, before the establishment of adaptive immune responses. Although many stimuli, including antigen, lipopolysaccharide, or cytokines, have been shown to activate B1 cells and induce their differentiation into plasma cells, the molecular signals required for their egress from the peritoneal cavity are not understood. We demonstrate here that direct signals through Toll-like receptors (TLRs) induce specific, rapid, and transient downregulation of integrins and CD9 on B1 cells, which is required for detachment from local matrix and a high velocity movement of cells in response to chemokines. Thus, we revealed an unexpected role for TLRs in governing the interplay between integrins, tetraspanins, and chemokine receptors required for B1 cell egress and, as such, in facilitating appropriate transition from innate to adaptive immune responses.
- リンク情報
- ID情報
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- DOI : 10.1084/jem.20061041
- ISSN : 0022-1007
- PubMed ID : 17060475
- Web of Science ID : WOS:000241670800018