1996年7月
Suppression of inducible nitric oxide synthase mRNA expression by tryptoquinone A
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
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- 巻
- 224
- 号
- 2
- 開始ページ
- 579
- 終了ページ
- 585
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1006/bbrc.1996.1067
- 出版者・発行元
- ACADEMIC PRESS INC JNL-COMP SUBSCRIPTIONS
Triptoquinone A (TQA), which is an anti-inflammatory constituent in plants, was studied for its suppressive effect on nitric oxide production by LPS. TQA significantly suppressed smooth muscle relaxation and increase in cyclic GMP levels by nitric oxide (NO) in an L-arginine-induced relaxation experiment. The mechanistic studies showed that TQA did not directly inhibit NO radicals and inducible nitric oxide synthase (iNOS) enzyme but suppressed IL-1 beta and iNOS mRNA expression by LPS. The suppression level of iNOS gene expression by TQA was comparable to that by dexamethasone. TQA may be a useful candidate for the development of a drug as a potent inhibitor of iNOS gene over-expression. (C) 1996 Academic Press, Inc.
- リンク情報
- ID情報
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- DOI : 10.1006/bbrc.1996.1067
- ISSN : 0006-291X
- Web of Science ID : WOS:A1996UY65600046