2008年11月
Capture of nonmagnetic particles and living cells using a microelectromagnetic system
JOURNAL OF APPLIED PHYSICS
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- 巻
- 104
- 号
- 9
- 開始ページ
- 94509
- 終了ページ
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1063/1.3010307
- 出版者・発行元
- AMER INST PHYSICS
We develop a microelectromagnetic system to trap nonmagnetic materials such as micropolystyrene particles and yeast cells in particular areas. We fabricate gold films, the width of the central narrow part is 22 mu m, and flow an electric current through the films. We then apply an external uniform dc magnetic field to weaken the local magnetic field at the narrow part so that a nonuniform magnetic field is produced. We demonstrate that the particles, which are dispersed in magnetic fluid, are successfully trapped at the narrow part of the film. We evaluate the driving force acting on a microparticle in the nonuniform magnetic field and carry out a Stokesian dynamics simulation of the motion of the particles. We show that yeast cells are also trapped at the narrow part of the film. Finally, we fabricate multichannel microelectromagnets so that yeast cells are trapped at multiple points in the microelectromagnetic system. The present system may be applied to cell transfection on a cell microarray and, therefore, eventually contribute to progress in the identification and determination technologies of different drug targets and the functions of genes and proteins. (C) 2008 American Institute of Physics. [DOI: 10.1063/1.3010307]
- リンク情報
- ID情報
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- DOI : 10.1063/1.3010307
- ISSN : 0021-8979
- Web of Science ID : WOS:000260941700123