2003年11月
[Advances in the diagnosis and treatment of cerebral ischemia during the acute phase].
Rinsho shinkeigaku = Clinical neurology
- ,
- 巻
- 43
- 号
- 11
- 開始ページ
- 887
- 終了ページ
- 90
- 記述言語
- 日本語
- 掲載種別
Recent advances in MRI technology and the development of effective neuroprotective agents has improved the outcome of stroke. In order to salvage tissue after an ischemic insult it is important to differentiate the core and penumbra area of the ischemic lesion. The penumbra surrounds the ischemic core, damage in this area is reversible if effective neuroprotective agents are given and reperfusion occurs. In this symposium detection of penumbra in an ischemic lesion using diffusion weighted imaging (DWI) and perfusion imaging (PI), diffusion-perfusion mismatch, and indications for thrombolytic therapy are discussed. If a hypoperfusion area is revealed with PI without a corresponding lesion indicated with DWI or when the DWI lesion is less than one third of the PI lesion, combined thrombolytic and neuroprotective therapies are recommended. In contrast, when both PI and DWI show an identical lesion, only neuroprotective therapy is advised. Additionally, newly developed neuroprotective agents, especially the combined effect of rt-PA and the immunosuppressant, FK506, on an embolic infarct model are discussed.
- リンク情報
- ID情報
-
- ISSN : 0009-918X
- PubMed ID : 15152494