2014年11月
Striatal direct and indirect pathways control decision-making behavior.
Frontiers in psychology
- ,
- ,
- 巻
- 5
- 号
- 開始ページ
- 1301
- 終了ページ
- 1301
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3389/fpsyg.2014.01301
Despite our ever-changing environment, animals are remarkably adept at selecting courses of action that are predictive of optimal outcomes. While requiring the contribution of a number of brain regions, a vast body of evidence implicates striatal mechanisms of associative learning and action selection to be critical to this ability. While numerous models of striatal-based decision-making have been developed, it is only recently that we have begun to understand the precise contributions of specific subpopulations of striatal neurons. Studies utilizing contemporary cell-type-specific technologies indicate that striatal output pathways play distinct roles in controlling goal-directed and social behaviors. Here we review current models of striatal-based decision-making, discuss recent developments in defining the functional roles of striatal output pathways, and assess how striatal dysfunction may contribute to the etiology of various neuropathologies.
- リンク情報
- ID情報
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- DOI : 10.3389/fpsyg.2014.01301
- PubMed ID : 25429278
- PubMed Central 記事ID : PMC4228842