2013年6月
RCAI-133, an N-methylated analogue of KRN7000, activates mouse natural killer T cells to produce Th2-biased cytokines
MEDCHEMCOMM
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- 巻
- 4
- 号
- 6
- 開始ページ
- 949
- 終了ページ
- 955
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1039/c3md00073g
- 出版者・発行元
- ROYAL SOC CHEMISTRY
We synthesized seven new analogues of KRN7000: RCAI-133 and 154-159. RCAI-154, 156 and 158 are secondary-amide analogues having a hydroxy, a methyl or two methyl groups at the alpha-position of a linear C-18-acyl chain, respectively. RCAI-155, 157 and 159 are corresponding N-methylated tertiary amide analogues, and RCAI-133 is the N-methylated KRN7000. Among them, a PBS solution of RCAI-133 induced mouse lymphocytes to produce Th2-biasing cytokines in vivo, while RCAI-154-159 showed only weak or almost no immunostimulatory activity. Therefore, N-methylation led the glycolipid to produce predominantly Th2-type cytokines, while acyl alpha-substitution was detrimental to activity.
- リンク情報
- ID情報
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- DOI : 10.1039/c3md00073g
- ISSN : 2040-2503
- eISSN : 2040-2511
- Web of Science ID : WOS:000319521900008