Hiroshi Kunugi

Profile Information

Affiliation: Professor and Chair, Teikyo University
: National Center of Neurology and Psychiatry

Degree: Ph.D.(Jun, 1994, The University of Tokyo)

J-GLOBAL ID: 200901005772392630
researchmap Member ID: 5000056473

External link: http://www.teikyo-psy.com/

統合失調症と気分障害の生物学的研究を行い、バイオマーカーと新たな治療法の開発を行っています。最近は、脳脊髄液をバイオリソースとした研究、食品成分の精神疾患治療への応用（精神栄養学）に関する研究を中心に行っています。

Research Interests

Research Areas

Research History

Apr, 2021 - Present

Professor and Chair, Department of Psychiatry, Teikyo University School of Medicine
Apr, 2020 - Present

National Center of Neurology and Psychiatry
Apr, 2020 - Present

Teikyo University
Apr, 2020 - Present

Visiting researcher, Department of Mental Disorder Research, National Center of Neurology and Psychiatry
May, 2002 - Mar, 2020

Director, Department of Mental Disorder Research, National Center of Neurology and Psychiatry
Jan, 1998 - May, 2002

Teikyo University
Apr, 1991 - Dec, 1997

assistant, School of Medicine, Department of Psychiatry and Neurology, Teikyo University

Major Papers

599

Analyzing schizophrenia-related phenotypes in mice caused by autoantibodies against NRXN1α in schizophrenia.

Hiroki Shiwaku, Shingo Katayama, Mengxuan Gao, Kanoh Kondo, Yuri Nakano, Yukiko Motokawa, Saori Toyoda, Fuyuko Yoshida, Hiroaki Hori, Tetsuo Kubota …

Brain, behavior, and immunity, 111 32-45, Mar 31, 2023
Simultaneous monitoring of activity and heart rate variability in depressed patients: A pilot study using a wearable monitor for 3 consecutive days

Norie Koga, Yoko Komatsu, Ryo Shinozaki, Ikki Ishida, Yusuke Shimizu, Sonoko Ishimaru, Hiroshi Kunugi

Neuropsychopharmacology Reports, 42(4) 457-467, Jul 29, 2022
Association between vascular endothelial growth factor-mediated blood-brain barrier dysfunction and stress-induced depression.

Hitomi Matsuno, Shoko Tsuchimine, Kazunori O'Hashi, Kazuhisa Sakai, Kotaro Hattori, Shinsuke Hidese, Shingo Nakajima, Shuichi Chiba, Aya Yoshimura, Noriko Fukuzato …

Molecular psychiatry, May 26, 2022
Recent advances in understanding depressive disorder: Possible relevance to brain stimulation therapies.

Hiroshi Kunugi, Maria Tikhonova

Progress in brain research, 270(1) 123-147, 2022
Effect of Lacticaseibacillus paracasei Strain Shirota on Improvement in Depressive Symptoms, and Its Association with Abundance of Actinobacteria in Gut Microbiota

Machiko Otaka, Hiroko Kikuchi-Hayakawa, Jun Ogura, Hiroshi Ishikawa, Yukihito Yomogida, Miho Ota, Shinsuke Hidese, Ikki Ishida, Masanori Aida, Kazunori Matsuda …

Microorganisms, 9(5) 1026-1026, May 10, 2021
Gut Microbiota and Pathophysiology of Depressive Disorder.

Hiroshi Kunugi

Annals of nutrition & metabolism, 77 Suppl 2 11-20, 2021
Performance on the Wechsler Adult Intelligence Scale ( WAIS ) in Japanese patients with bipolar and major depressive disorders in euthymic and depressed states

Junko Matsuo, Hiroaki Hori, Ikki Ishida, Moeko Hiraishi, Miho Ota, Shinsuke Hidese, Yukihito Yomogida, Hiroshi Kunugi

Psychiatry and Clinical Neurosciences, 75(4) 128-137, Dec 27, 2020
Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.

Shinsuke Hidese, Shintaro Ogawa, Miho Ota, Ikki Ishida, Zenta Yasukawa, Makoto Ozeki, Hiroshi Kunugi

Nutrients, 11(10), Oct 3, 2019 Peer-reviewed
Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans.

Hiroshi Kunugi, Amira Mohammed Ali

International journal of molecular sciences, 20(19), Sep 20, 2019
Altered polyunsaturated fatty acid levels in relation to proinflammatory cytokines, fatty acid desaturase genotype, and diet in bipolar disorder.

Koga N, Ogura J, Yoshida F, Hattori K, Hori H, Aizawa E, Ishida I, Kunugi H

Translational psychiatry, 9(1) 208-208, Aug, 2019 Peer-reviewed
Effects of Chronic L-theanine on Stress-related Symptoms and Cognitive Function in a Non-clinical Population: A Randomized Controlled Trial (P06-106-19)

Hiroshi Kunugi, Shinsuke Hidese, Shintaro Ogawa, Miho Ota, Zenta Yasukawa, Makoto Ozeki

Current Developments in Nutrition, 3(Supplement_1), Jun 1, 2019
Cerebrospinal fluid BDNF pro-peptide levels in major depressive disorder and schizophrenia.

Mizui T, Hattori K, Ishiwata S, Hidese S, Yoshida S, Kunugi H, Kojima M

Journal of psychiatric research, 113 190-198, Jun, 2019 Peer-reviewed
Food allergy is associated with depression and psychological distress: A web-based study in 11,876 Japanese.

Hidese S, Nogawa S, Saito K, Kunugi H

Journal of affective disorders, 245 213-218, Feb, 2019 Peer-reviewed
Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer's disease.

Miho Ota, Junko Matsuo, Ikki Ishida, Harumasa Takano, Yuma Yokoi, Hiroaki Hori, Sumiko Yoshida, Kinya Ashida, Kentaro Nakamura, Takeshi Takahashi …

Neuroscience letters, 690 232-236, Jan 18, 2019 Peer-reviewed
Reduced plasma orexin-A levels in patients with bipolar disorder.

Shoko Tsuchimine, Kotaro Hattori, Miho Ota, Shinsuke Hidese, Toshiya Teraishi, Daimei Sasayama, Hiroaki Hori, Takamasa Noda, Sumiko Yoshida, Fuyuko Yoshida …

Neuropsychiatric disease and treatment, 15 2221-2230, 2019 Peer-reviewed
Cerebrospinal fluid monoamine metabolite concentrations in depressive disorder: A meta-analysis of historic evidence.

Shintaro Ogawa, Shoko Tsuchimine, Hiroshi Kunugi

Journal of psychiatric research, 105 137-146, Oct, 2018 Peer-reviewed
Association of depression with body mass index classification, metabolic disease, and lifestyle: A web-based survey involving 11,876 Japanese people

Shinsuke Hidese, Shinya Asano, Kenji Saito, Daimei Sasayama, Hiroshi Kunugi

Journal of Psychiatric Research, 102 23-28, Jul 1, 2018 Peer-reviewed
Association between iron-deficiency anemia and depression: A web-based Japanese investigation.

Hidese S, Saito K, Asano S, Kunugi H

Psychiatry and clinical neurosciences, 72(7) 513-521, Jul, 2018 Peer-reviewed
Relationship of handgrip strength and body mass index with cognitive function in patients with schizophrenia

Shinsuke Hidese, Junko Matsuo, Ikki Ishida, Moeko Hiraishi, Toshiya Teraishi, Miho Ota, Kotaro Hattori, Hiroshi Kunugi

Frontiers in Psychiatry, 9 156, Apr 25, 2018 Peer-reviewed
Sensorimotor gating in depressed and euthymic patients with bipolar disorder: Analysis on prepulse inhibition of acoustic startle response stratified by gender and state

Junko Matsuo, Miho Ota, Shinsuke Hidese, Toshiya Teraishi, Hiroaki Hori, Ikki Ishida, Moeko Hiraishi, Hiroshi Kunugi

Frontiers in Psychiatry, 9 123, Apr 18, 2018 Peer-reviewed
13C-phenylalanine breath test and serum biopterin in schizophrenia, bipolar disorder and major depressive disorder

Toshiya Teraishi, Masahiro Kajiwara, Hiroaki Hori, Daimei Sasayama, Shinsuke Hidese, Junko Matsuo, Ikki Ishida, Yasuhiro Kajiwara, Yuji Ozeki, Miho Ota …

Journal of Psychiatric Research, 99 142-150, Apr 1, 2018 Peer-reviewed
The use of diffusional kurtosis imaging and neurite orientation dispersion and density imaging of the brain in major depressive disorder

Miho Ota, Takamasa Noda, Noriko Sato, Shinsuke Hidese, Toshiya Teraishi, Shiori Setoyama, Daichi Sone, Hiroshi Matsuda, Hiroshi Kunugi

Journal of Psychiatric Research, 98 22-29, Mar 1, 2018 Peer-reviewed
Association of obesity with cognitive function and brain structure in patients with major depressive disorder

Shinsuke Hidese, Miho Ota, Junko Matsuo, Ikki Ishida, Moeko Hiraishi, Sumiko Yoshida, Takamasa Noda, Noriko Sato, Toshiya Teraishi, Kotaro Hattori …

JOURNAL OF AFFECTIVE DISORDERS, 225 188-194, Jan, 2018 Peer-reviewed
Plasma amino acid profile in major depressive disorder: Analyses in two independent case-control sample sets

Shintaro Ogawa, Norie Koga, Kotaro Hattori, Junko Matsuo, Miho Ota, Hiroaki Hori, Daimei Sasayama, Toshiya Teraishi, Ikki Ishida, Fuyuko Yoshida …

Journal of Psychiatric Research, 96 23-32, Jan 1, 2018 Peer-reviewed
Association of obesity with cognitive function and brain structure in patients with major depressive disorder

Shinsuke Hidese, Miho Ota, Junko Matsuo, Ikki Ishida, Moeko Hiraishi, Sumiko Yoshida, Takamasa Noda, Noriko Sato, Toshiya Teraishi, Kotaro Hattori …

Journal of Affective Disorders, 236 314, Jan 1, 2018 Peer-reviewed
Bifidobacterium and Lactobacillus Counts in the Gut Microbiota of Patients With Bipolar Disorder and Healthy Controls.

Aizawa E, Tsuji H, Asahara T, Takahashi T, Teraishi T, Yoshida S, Koga N, Hattori K, Ota M, Kunugi H

Frontiers in psychiatry, 9 730-730, 2018 Peer-reviewed
Relationships of Cerebrospinal Fluid Monoamine Metabolite Levels With Clinical Variables in Major Depressive Disorder

Hyung Shin Yoon, Kotaro Hattori, Shintaro Ogawa, Daimei Sasayama, Miho Ota, Toshiya Teraishi, Hiroshi Kunugi

JOURNAL OF CLINICAL PSYCHIATRY, 78(8) E947-+, Sep, 2017 Peer-reviewed
Effects of chronic l-theanine administration in patients with major depressive disorder: An open-label study

Shinsuke Hidese, Miho Ota, Chisato Wakabayashi, Takamasa Noda, Hayato Ozawa, Tsutomu Okubo, Hiroshi Kunugi

Acta Neuropsychiatrica, 29(2) 72-79, Apr 1, 2017 Peer-reviewed
Sexually dimorphic deficits of prepulse inhibition in patients with major depressive disorder and their relationship to symptoms: A large single ethnicity study

Junko Matsuo, Miho Ota, Shinsuke Hidese, Hiroaki Hori, Toshiya Teraishi, Ikki Ishida, Moeko Hiraishi, Hiroshi Kunugi

JOURNAL OF AFFECTIVE DISORDERS, 211 75-82, Mar, 2017 Peer-reviewed
Genome-wide quantitative trait loci mapping of the human cerebrospinal fluid proteome

Daimei Sasayama, Kotaro Hattori, Shintaro Ogawa, Yuuki Yokota, Ryo Matsumura, Toshiya Teraishi, Hiroaki Hori, Miho Ota, Sumiko Yoshida, Hiroshi Kunugi

HUMAN MOLECULAR GENETICS, 26(1) 44-51, Jan, 2017 Peer-reviewed
A large single ethnicity study of prepulse inhibition in schizophrenia: Separate analysis by sex focusing on effect of symptoms

Junko Matsuo, Miho Ota, Hiroaki Hori, Shinsuke Hidese, Toshiya Teraishi, Ikki Ishida, Moeko Hiraishi, Hiroshi Kunugi

JOURNAL OF PSYCHIATRIC RESEARCH, 82 155-162, Nov, 2016 Peer-reviewed
Effect of a ketogenic meal on cognitive function in elderly adults: potential for cognitive enhancement

Miho Ota, Junko Matsuo, Ikki Ishida, Kotaro Hattori, Toshiya Teraishi, Hidekazu Tonouchi, Kinya Ashida, Takeshi Takahashi, Hiroshi Kunugi

PSYCHOPHARMACOLOGY, 233(21-22) 3797-3802, Oct, 2016 Peer-reviewed
Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder

Emiko Aizawa, Hirokazu Tsuji, Takashi Asahara, Takuya Takahashi, Toshiya Teraishi, Sumiko Yoshida, Miho Ota, Norie Koga, Kotaro Hattori, Hiroshi Kunugi

JOURNAL OF AFFECTIVE DISORDERS, 202 254-257, Sep, 2016 Peer-reviewed
24-h activity rhythm and sleep in depressed outpatients

Hiroaki Hori, Node Koga, Shinsuke Hidese, Anna Nagashima, Yoshiharu Kim, Teruhiko Higuchi, Hiroshi Kunugi

JOURNAL OF PSYCHIATRIC RESEARCH, 77 27-34, Jun, 2016 Peer-reviewed
Effect of electroconvulsive therapy on gray matter volume in major depressive disorder

Miho Ota, Takamasa Noda, Noriko Sato, Mitsutoshi Okazaki, Masatoshi Ishikawa, Kotaro Hattori, Hiroaki Hori, Daimei Sasayama, Toshiya Teraishi, Daichi Sone …

JOURNAL OF AFFECTIVE DISORDERS, 186 186-191, Nov, 2015 Peer-reviewed
C-13-tryptophan breath test detects increased catabolic turnover of tryptophan along the kynurenine pathway in patients with major depressive disorder

Toshiya Teraishi, Hiroaki Hori, Daimei Sasayama, Junko Matsuo, Shintaro Ogawa, Miho Ota, Kotaro Hattori, Masahiro Kajiwara, Teruhiko Higuchi, Hiroshi Kunugi

SCIENTIFIC REPORTS, 5 15994, Nov, 2015 Peer-reviewed
Effect of L-theanine on glutamatergic function in patients with schizophrenia

Miho Ota, Chisato Wakabayashi, Noriko Sato, Hiroaki Hori, Kotaro Hattori, Toshiya Teraishi, Hayato Ozawa, Tsutomu Okubo, Hiroshi Kunugi

ACTA NEUROPSYCHIATRICA, 27(5) 291-296, Oct, 2015 Peer-reviewed
Biochemical markers subtyping major depressive disorder

Hiroshi Kunugi, Hiroaki Hori, Shintaro Ogawa

PSYCHIATRY AND CLINICAL NEUROSCIENCES, 69(10) 597-608, Oct, 2015 Peer-reviewed
Increased cerebrospinal fluid fibrinogen in major depressive disorder

Kotaro Hattori, Miho Ota, Daimei Sasayama, Sumiko Yoshida, Ryo Matsumura, Tomoko Miyakawa, Yuuki Yokota, Shinobu Yamaguchi, Takamasa Noda, Toshiya Teraishi …

SCIENTIFIC REPORTS, 5 11412, Jun, 2015 Peer-reviewed
Autistic-Like Traits in Adult Patients with Mood Disorders and Schizophrenia

Junko Matsuo, Yoko Kamio, Hidetoshi Takahashi, Miho Ota, Toshiya Teraishi, Hiroaki Hori, Anna Nagashima, Reiko Takei, Teruhiko Higuchi, Nobutaka Motohashi …

PLOS ONE, 10(4) e0122711, Apr, 2015 Peer-reviewed
Effect of L-theanine on glutamatergic function in patients with schizophrenia

Miho Ota, Chisato Wakabayashi, Noriko Sato, Hiroaki Hori, Kotaro Hattori, Toshiya Teraishi, Hayato Ozawa, Tsutomu Okubo, Hiroshi Kunugi

Acta Neuropsychiatrica, 27(5) 291-296, Mar 16, 2015 Peer-reviewed
Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder

Shintaro Ogawa, Kotaro Hattori, Daimei Sasayama, Yuki Yokota, Ryo Matsumura, Junko Matsuo, Miho Ota, Hiroaki Hori, Toshiya Teraishi, Sumiko Yoshida …

SCIENTIFIC REPORTS, 5 7796, Jan, 2015 Peer-reviewed
Plasma L-Tryptophan Concentration in Major Depressive Disorder: New Data and Meta-Analysis

Shintaro Ogawa, Takashi Fujii, Norie Koga, Hiroaki Hori, Toshiya Teraishi, Kotaro Hattori, Takamasa Noda, Teruhiko Higuchi, Nobutaka Motohashi, Hiroshi Kunugi

JOURNAL OF CLINICAL PSYCHIATRY, 75(9) E906-E915, Sep, 2014 Peer-reviewed
Effect of L-theanine on sensorimotor gating in healthy human subjects

Miho Ota, Chisato Wakabayashi, Junko Matsuo, Yukiko Kinoshita, Hiroaki Hori, Kotaro Hattori, Daimei Sasayama, Toshiya Teraishi, Satoko Obu, Hayato Ozawa …

PSYCHIATRY AND CLINICAL NEUROSCIENCES, 68(5) 337-343, May, 2014 Peer-reviewed
Pseudo-continuous arterial spin labeling MRI study of schizophrenic patients

Miho Ota, Masanori Ishikawa, Noriko Sato, Mitsutoshi Okazaki, Norihide Maikusa, Hiroaki Hori, Kotaro Hattori, Toshiya Teraishi, Kimiteru Ito, Hiroshi Kunugi

SCHIZOPHRENIA RESEARCH, 154(1-3) 113-118, Apr, 2014 Peer-reviewed
Effect of the common functional FKBP5 variant (rs1360780) on the hypothalamic-pituitary-adrenal axis and peripheral blood gene expression

Takashi Fujii, Hiroaki Hori, Miho Ota, Kotaro Hattori, Toshiya Teraishi, Daimei Sasayama, Noriko Yamamoto, Teruhiko Higuchi, Hiroshi Kunugi

PSYCHONEUROENDOCRINOLOGY, 42 89-97, Apr, 2014 Peer-reviewed

Misc.

246

精神疾患と腸内細菌叢のかかわりを探る

功刀浩(監修)

Trends in Psychiatric Science, 1-3, Feb, 2024 Invited
この書籍から学んだこと：精神科医による書籍紹介

功刀浩

CNS情報Plus, 31 8-8, Feb, 2024 InvitedLead author
ストレスでうつ病になるのはどうしてですか？

功刀浩

CLINICAL NEUROSCIENCE, 41(10) 1375-1375, Oct, 2023 InvitedLead author
うつを予防・改善するための食生活

功刀浩

中学保健ニュース, (1886), Jul 18, 2023 Invited
心の健康を支える食習慣

功刀浩

中学保健ニュース, (1886), Jul 18, 2023
Hypothalamic-pituitary-adrenal axis and renin-angiotensin-aldosterone system in adulthood PTSD and childhood maltreatment history(タイトル和訳中)

筧亮子, 堀弘明, 吉田冬子, 伊藤真利子, 林明明, 丹羽まどか, 成田恵, 井野敬子, 今井理紗, 篠山大明 …

国立精神・神経医療研究センター精神保健研究所年報, (36) 204-204, Jul, 2023
【脳腸相関UPDATE-疾患の予防と健康長寿のための食・栄養・腸環境】(Part3)脳腸相関と食・栄養地中海食

功刀浩

臨床栄養, 142(6) 983-989, May, 2023
気分障害におけるストレス要因を規定する栄養・腸内環境の解明

功刀浩

先進医薬研究振興財団研究成果報告集, 2022年度 14-16, Mar, 2023
うつ病とアミノ酸

功刀浩

アミノ酸研究, 16(1) 41-45, Mar, 2023
神経疾患における欧米食とケトン食：その違いとは？

橋本みどり, 功刀浩(翻, 板倉弘重

栄養学レビュー, 80(8-10) 188-206, 2023 Invited
うつ病と栄養について

功刀浩

CNS情報Plus, 27 8-8, Jan, 2023 InvitedLead author
アルツハイマー型認知症の病型診断における髄液検査が有用だった1例

種田将, 赤羽晃寿, 渡邊公聡, 金田渉, 秀瀬真輔, 佐藤研一, 功刀浩

精神神経学雑誌, 125(1) 85-85, Jan, 2023
気分障害と腸内フローラ新たな治療の可能性とメカニズム

功刀浩

日本心療内科学会誌, 26(別冊) 140-140, Nov, 2022
うつ病患者に対する栄養食事指導精神科外来での実践に関する後方視調査から

宮本佳世子, 笠原康平, 功刀浩

New Diet Therapy, 38(2) 213-213, Sep, 2022
統合失調症入院患者を対象とした高尿酸血症リスク因子に関する探索的後方視研究

笠原康平, 宮本佳世子, 大森まゆ, 大町佳永, 功刀浩

New Diet Therapy, 38(2) 214-214, Sep, 2022
男性の性腺機能低下症ガイドライン2022

堀江重郎, 天野俊康, 石井智弘, 井手久満, 伊藤直樹, 岩月正一郎, 上芝元, 大山力, 小川純人, 蔭山和則 …

日本内分泌学会雑誌, 98(Suppl.) np1-140, Jul, 2022
男性の性腺機能低下症ガイドライン2022

堀江重郎, 天野俊康, 石井智弘, 井手久満, 伊藤直樹, 岩月正一郎, 上芝元, 大山力, 小川純人, 蔭山和則 …

日本内分泌学会雑誌, 98(Suppl.) np1-140, Jul, 2022
排泄障害への牛車腎気丸服用後にADLと認知機能が改善したウェルニッケ・コルサコフ症候群(WKS)の1例

野村芳子, 秀瀬真輔, 金井理恵, 押久保岳, 渡邊由香子, 赤羽晃寿, 栃木衛, 功刀浩

精神神経学雑誌, 124(4付録) S-388, Apr, 2022
精神疾患マネジメントをめぐる身体科医や多職種との連携・協働神経精神症状を伴うSLE(NPSLE)に対する診療科連携による診断・治療への取り組み

岩田慈, 藤田悠哉, 秀瀬真輔, 石渡小百合, 服部功太郎, 池ノ内篤子, 功刀浩, 吉村玲児, 田中良哉

精神神経学雑誌, 124(4付録) S-657, Apr, 2022
大うつ病性障害および統合失調症における脳脊髄液リゾホスファチジン酸ドコサヘキサエン酸(LPA-DHA)の減少

大盛航, 可野邦行, 服部功太郎, 梶谷直人, 岡田麻美, 朴秀賢, 功刀浩, 青木淳賢, 竹林実

精神神経学雑誌, 124(4付録) S-641, Apr, 2022

Books and Other Publications

食生活習慣とうつ病リスク

功刀浩 (Role: Joint author, 「疾病予防・健康寿命延伸に資する栄養・食生活とは？」（津金昌一郎編）、別冊医学のあゆみ、pp.31-36.)

医歯薬出版、東京, Nov, 2023
薬だけに頼らずうつがみるみる遠ざかる食べ方大全

功刀浩

文響社, Jun 13, 2023
美味しく食べてメンタルケア : 精神栄養学最前線

功刀, 浩, 中央労働災害防止協会

中央労働災害防止協会, Apr, 2022 (ISBN: 9784805920473)
臨床に役立つ精神疾患の栄養食事指導

功刀, 浩, 阿部, 裕二

講談社, Jul, 2021 (ISBN: 9784065213254)
発達障害食事・栄養・キレーション療法をご存じですか? : 症例に合った心と身体に優しい療法

樋田, 毅, 功刀, 浩

ウェイツ, Feb, 2020 (ISBN: 9784904979297)
心の病を治す食事・運動・睡眠の整え方

功刀, 浩

翔泳社, Jan, 2019 (ISBN: 9784798157733)
精神疾患は脳の病気か? : 向精神薬の科学と虚構

Valenstein, Elliot S., 功刀, 浩, 中塚, 公子

みすず書房, Apr, 2018 (ISBN: 9784622086987)
読めば気持ちがす～っと軽くなる本人・家族に優しい統合失調症のお話

功刀, 浩

翔泳社, Jan, 2018 (ISBN: 9784798153322)
こころに効く精神栄養学

功刀, 浩

女子栄養大学出版部, Mar, 2016 (ISBN: 9784789554459)
うつ病の毎日ごはん : 国立精神・神経医療研究センターの医師と管理栄養士が教える

功刀, 浩, 今泉, 博文

女子栄養大学出版部, Apr, 2015 (ISBN: 9784789518765)
うつ病 : 治療・研究の最前線

功刀, 浩

医歯薬出版, Feb, 2014
精神疾患の薬物療法講義 : 研修医・コメディカルのための

功刀, 浩

金剛出版, Jun, 2013 (ISBN: 9784772413152)
うつ病 : 治療・研究の最前線

功刀, 浩

医歯薬出版, Feb, 2013
図解やさしくわかる統合失調症 : 正しい理解と付き合い方

功刀, 浩

ナツメ社, Aug, 2012 (ISBN: 9784816352508)
精神疾患の脳科学講義

功刀, 浩

金剛出版, Jul, 2012 (ISBN: 9784772412629)
精神・神経疾患のバイオマーカーの探索と臨床応用に関する研究研究報告書

功刀, 浩

[功刀浩], Mar, 2012
精神疾患診断のための脳形態・機能検査法

三国, 雅彦, 福田, 正人, 功刀, 浩

新興医学出版社, Feb, 2012 (ISBN: 9784880027302)
統合失調症の常識は本当か? : 研究と治療の最前線から

McDonald, Colm, Schulze, Katja, Murray, Robin M., Wright, Padraig, 功刀, 浩, 堀, 弘明

培風館, Jul, 2009 (ISBN: 9784563052089)
統合失調症100のQ&A : 苦しみを乗り越えるために

DeLisi, Lynn E., 功刀, 浩, 堀, 弘明

星和書店, Apr, 2008 (ISBN: 9784791106585)
精神疾患は脳の病気か? : 向精神薬の科学と虚構

Valenstein, Elliot S., 中塚, 公子, 功刀, 浩

みすず書房, Feb, 2008 (ISBN: 9784622073611)

Presentations

Altered circadian rhythm of activity and heart rate variability in depression

Kunugi H

The 101st Annual Meeting of the Physiological Society of Japan, Mar 29, 2024 Invited
Cellular phenotypes and causal candidate genes in iPSC-derived neurons of bipolar disorder family patients.
精神疾患を支える食支援

功刀浩

特別区職員研修所令和5年度専門研修「栄養士」, Feb 2, 2024 Invited
精神疾患と栄養・食事・サプリメント

功刀浩

神戸薬科大学エクステンションセンター生涯研修支援プログラム第52回健康食品講座（e-learning:オンデマンド配信） Invited
うつ病の病態と栄養学的アプローチ・ムードフード

功刀浩

第5回ヘルスフードアカデミックサロン（文京シビックホール）, Jan 29, 2024 Invited
うつ病の栄養学的治療

功刀浩

東京理科大学医療薬学教育研究支援センター薬学ベーシックコース薬物治療アップトゥデート講座⑦（オンライン講演）, Jan 20, 2024 Invited
うつ病の病態仮説と治療薬

功刀浩

東京理科大学医療薬学教育研究支援センター薬学ベーシックコース薬物治療アップトゥデート講座⑦（オンライン講演）, Jan 20, 2024 Invited
うつ病と生活習慣（病）

功刀浩

第57回日本成人病（生活習慣病）学会学術集会イブニングセミナー（MSD後援）, Jan 13, 2024 Invited
うつ病の栄養学的アプローチ

功刀浩

Meiji社内オンラインセミナー, Jan 12, 2024 Invited
統合失調症の病態と薬物療法・栄養学的介入

功刀浩

第96回板薬イブニングセミナーオンライン講演（板橋区薬剤師会、住友ファーマ共催）, Dec 21, 2023 Invited
Cellular phenotypes and causal candidate genes in iPSC-derived neurons of bipolar disorder family patients

Dec 8, 2023
ベンゾジアゼピン受容体作動薬の処方制限は過量服薬による自殺企図を減らしたか？

赤羽晃寿, 松村謙一, 金井理恵, 功刀浩

第36回日本総合病院精神医学会総会, Nov 17, 2023
精神科治療に有用な栄養学的知識と実践：うつ病を中心に

功刀浩

第36回日本総合病院精神医学会総会ランチョンセミナー6（ノーベルファーマ、メディパルホールディングス共催）, Nov 18, 2023 Invited
活力ある生活を維持するための習慣：食生活を中心に

功刀浩

さいたま市教育委員会学校給食部門講演会(さいたま市プラザノース), Nov 16, 2023
メンタルヘルスによい食と栄養～リカバリーへの栄養学的アプローチ～

功刀浩

リカバリー全国フォーラム2023（地域精神保健福祉機構 COHMBO主催）オンライン配信, Nov 8, 2023 Invited
うつ病と腸内マイクロバイオーム

功刀浩

第45回日本生物学的精神医学会年会シンポジウム10、万国津梁館、沖縄, Nov 7, 2023
精神疾患と腸-相関・代謝

功刀浩

第45回日本生物学的精神医学会年会ランチョンセミナー２（Meijiseikaファルマ共催）万国津梁館、沖縄, Nov 6, 2023 Invited
栄養とメンタルヘルス

功刀浩

メンタルヘルスマネジメント概論（2023年度早稲田大学秋学期・講義）, Nov 1, 2023 Invited
精神栄養学

功刀浩

令和5年度広島県栄養士会生涯教育研修会、2023年10月22日、オンライン開催, Oct 22, 2023 Invited
深刻な自殺企図を行なったが、てんかん発作後に自殺念慮が消失した１例-低コルチゾル血症関与の可能性-

藤井亮佑、小方茂弘、松村謙一、渡邊由香子、赤羽晃寿、菅野道、功刀浩

第42回躁うつ病の薬理・生化学的研究懇話会、皆生グランドホテル天水、鳥取, Oct 20, 2023

Teaching Experience

Apr, 2020 - Present

Psychiatry (Teikyo University)
2019 - Present

メンタルヘルス概論（早稲田大学）
2004 - 2019

神経科学の最前線（早稲田大学理工学術院）

Professional Memberships

Apr, 2020 - Present

Japanese Society for Child and Adolescent Psychiatry
2020 - Present

東京精神医学会
2014 - Present

Japanese Society of Nutrition and Food Science
2012 - Present

International College of Neuropsychopharmacology
Apr, 2011 - Present

Japanese Clinical Nutrition Association
Feb, 2011 - Present

Japanese Society of Clinical Nutrition
Jul, 2009 - Present

Japanese Society of Mood Disorders
Aug, 2005 - Present

日本統合失調症学会
Oct, 2002 - Present

日本臨床精神神経薬理学会
Jun, 2002 - Present

Japanese Society of Neuroscience
Jan, 2001 - Present

Japanese Society of Sleep Research
Jan, 2000 - Present

Japanese Society of Geriatric Psychiatry
Nov, 1995 - Present

Japanese Society of Biological Psychiatry
Apr, 1990 - Present

日本社会精神医学会
Sep, 1988 - Present

Japanese Society of General Hospital Psychiatry
Apr, 1987 - Present

Japanese Society of Psychiatry and Neurology
- Present

日本神経精神薬理学会

Research Projects

Creation and clinical application of 3D brain barrier chips using human iPS cells

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
[1-13C]Trpと[1-13C]5-HTPの合成とうつ病の客観的診断法の開発

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

梶原康宏, 庄司満, 功刀浩
Study of drug discovery and biomarker for depression based on glial antidepressant receptor (LPA1)

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2023
Research on molecular and brain basis for sensorimotor gating dysfunction

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Matsuo Junko
A personality-based examination of the health-illness continuum: association with gene expression profiles

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Jul, 2016 - Mar, 2019

Hori Hiroaki, KUNUGI Hiroshi, YOSHIDA Fuyuko, NAKAMURA Seiji, KIM Yoshiharu, HIGUCHI Teruhiko
Development of a novel biomarker and treatment for major depressive disorder focusing on the ethanolamine in the cerebrospinal fluid

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2018

OGAWA Shintaro, KUNUGI Hiroshi, HATTORI Kotaro, OTA Miho, MATSUO Junko, CHIBA Shuichi
Translational study on exercise program for promoting vitality of body and mind: unravel the mechanism of enhancing motivation and cognitive function in brain.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

SOYA Hideaki
Study on the serotonin kynurenine hypothesis by the stable isotope breath test in mood disorder

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Teraishi Toshiya, KUNUGI Hiroshi, KAJIWARA Masahiro
Study on the clinical use of (13)C-tryptophan breath test in depressive disorder

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

Kunugi Hiroshi, TERAISHI Toshiya
Quantitative analysis of lysophosphatidic acid (LPA) in serum and cerebrospinal fluid of depressed patients

Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B), Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2017

GOTOH LEO, YAMADA Mitsuhiko, SAITO Akiyoshi, YAMADA Misa, HATTORI Kotaro, KUNUGI Hiroshi
Development of biomarkers for functional psychoses based on multiple omics analyses

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A), Grant-in-Aid for Scientific Research (A), Japan Society for the Promotion of Science, Oct, 2013 - Mar, 2016

Kunugi Hiroshi, HATTORI Kotaro, SASAYAMA Daimei
うつ病の発症におけるＣＡＲＴの役割；人と動物を対象とした研究

科学研究費助成事業特別研究員奨励費, 特別研究員奨励費, 日本学術振興会, 2012 - 2013

功刀浩, YOON HyungShin
The application of stable isotope breath test and biopterin administration to the evaluation and treatment of psychiatric disorders

Grants-in-Aid for Scientific Research Grant-in-Aid for Challenging Exploratory Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, 2010 - 2011

KUNUGI Hiroshi
Role of neurotrophin receptor p75 in psychiatric diseases

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2008 - 2011

KUNUGI Hiroshi, NUMAKAWA Tadahiro, FUJII Takashi
A Search for Risk Genes of Psychiatric Disorders

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research on Priority Areas, Grant-in-Aid for Scientific Research on Priority Areas, Japan Society for the Promotion of Science, 2005 - 2009

OKAZAKI Yuji
Search and functional analysis for candidate gene of schizophrenia by CGH array method.

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C), Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008

OZEKI Yuji, KUNUGI Hiroshi
Molecular genetic study on the pathophysiology of psychiatric disorders based on the role of PACAP

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2006 - 2008

SHINTANI Norihito, BABA Akemichi, AGO Yukio, HASHIMOTO Ryota, KUNUGI Hiroshi, TOHYAMA Masaya, TAKEDA Masatoshi
プレパルス抑制検査を用いた統合失調症の病態の解明と診断法の開発

科学研究費助成事業萌芽研究, 萌芽研究, 日本学術振興会, 2003 - 2005

功刀浩
メチル化によるエピジェネティクなゲノム変化と統合失調症との関連解析

科学研究費助成事業萌芽研究, 萌芽研究, 日本学術振興会, 2003 - 2004

北條浩彦, 功刀浩
Phylogenetic analyses of the HLA-DRB1 gene based on the DR haplotypes

Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B), Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2002 - 2003

HOHJOH Hirohiko, TOKUNAGA Katsushi, ISHIDA Takafumi, KUNUGI Hiroshi

Education

Apr, 1982 - Mar, 1986

医学科, 東京大学医学部
Apr, 1980 - Mar, 1982

College of Arts and Sciences, The University of Tokyo

Media Coverage

将棋対局中の脳のエネルギー消費と栄養に関する取材

東海テレビ, ＮＥＷＳＯＮＥ, Mar 29, 2024 TV or radio program
勝負決める！？甘味の力藤井聡太さん、王座戦での一品は－－速効で脳に栄養、心の安定一方で弊害も

毎日新聞夕刊総合, 毎日新聞夕刊総合, カルチャー, Aug 21, 2023 Newspaper, magazine
心の健康にも食事は大切！メンタルヘルスと栄養の関係

サワイ健康推進課, 季節のテーマ, https://kenko.sawai.co.jp/theme/202307.html, Jul, 2023 Internet

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