This paper is concerned with strong blow-up instability (Definition 1.3) for standing wave solutions to the system of the quadratic nonlinear Klein-Gordon equations. In the single case, namely the nonlinear Klein-Gordon equation with power type nonlinearity, stability and instability for standing wave solutions have been extensively studied. On the other hand, in the case of our system, there are no results concerning the stability and instability as far as we know. In this paper, we prove strong blow-up instability for the standing wave to our system. The proof is based on the techniques in Ohta and Todorova [25]. It turns out that we need the mass resonance condition in two or three space dimensions whose cases are the mass-subcritical case.