Jan, 2017
Unstable bodyweight and incident type 2 diabetes mellitus: A meta-analysis.
Journal of diabetes investigation
- Volume
- 8
- Number
- 4
- First page
- 501
- Last page
- 509
- Language
- English
- Publishing type
- Research paper (scientific journal)
- DOI
- 10.1111/jdi.12623
- Publisher
- WILEY
AIMS/INTRODUCTION: The present meta-analysis aimed to clarify the association of unstable bodyweight with the risk of type 2 diabetes mellitus, an association that has been controversial among longitudinal studies. MATERIALS AND METHODS: An electronic literature search using EMBASE and MEDLINE was followed up to 31 August 2016. The relative risks (RRs) of type 2 diabetes mellitus in individuals with unstable bodyweight were pooled using the inverse variance method. RESULTS: Eight studies were eligible for the meta-analysis. The median duration of measurements of weight change and follow-up years for ascertaining type 2 diabetes mellitus were 13.5 and 9.4 years, respectively. The pooled RR for the least vs most stable category was 1.33 (95% confidence interval 1.12-1.57). Between-study heterogeneity was statistically significant (P = 0.048). Whether type 2 diabetes mellitus was ascertained by blood testing explained 66.0% of the variance in the logarithm of RR (P = 0.02). In three studies in which blood testing was carried out, type 2 diabetes mellitus risk was not significant (RR 1.06, 95% confidence interval 0.91-1.25). Furthermore, publication bias that inflated type 2 diabetes mellitus risk was statistically detected by Egger's test (P = 0.09). CONCLUSIONS: Unstable bodyweight might be modestly associated with the elevated risk of type 2 diabetes mellitus; although serious biases, such as diagnostic suspicion bias and publication bias, made it difficult to assess this association.
- Link information
-
- DOI
- https://doi.org/10.1111/jdi.12623
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/28083921
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5497032
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000404917100014&DestApp=WOS_CPL
- URL
- http://europepmc.org/abstract/med/28083921
- ID information
-
- DOI : 10.1111/jdi.12623
- ISSN : 2040-1116
- ORCID - Put Code : 34014855
- Pubmed ID : 28083921
- Pubmed Central ID : PMC5497032
- Web of Science ID : WOS:000404917100014