2017年4月
Gomisin N Decreases Inflammatory Cytokine Production in Human Periodontal Ligament Cells.
Inflammation
- 巻
- Vol.40
- 号
- No.2
- 開始ページ
- 360
- 終了ページ
- 365
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s10753-016-0482-4
Gomisin N, which is a lignan isolated from Schisandra chinensis, has some pharmacological effects. However, the anti-inflammatory effects of gomisin N on periodontal disease are uncertain. The aim of this study was to examine the effect of gomisin N on inflammatory mediator production in tumor necrosis factor (TNF)--stimulated human periodontal ligament cells (HPDLC). Gomisin N inhibited interleukin (IL)-6, IL-8, CC chemokine ligand (CCL) 2, and CCL20 production in TNF--stimulated HPDLC in a dose-dependent manner. Moreover, we revealed that gomisin N could suppress extracellular signal-regulated kinase (ERK) and c-Jun N terminal kinase (JNK) phosphorylation in TNF--stimulated HPDLC though protein kinase B (Akt) phosphorylation was not suppressed by gomisin N treatment. In summary, gomisin N might exert anti-inflammatory effects by attenuating cytokine production in periodontal ligament cells via inhibiting the TNF--stimulated ERK and JNK pathways activation.
- リンク情報
- ID情報
-
- DOI : 10.1007/s10753-016-0482-4
- ISSN : 1573-2576
- PubMed ID : 27896541