論文

査読有り 本文へのリンクあり
2016年

Perioperative elevation in cell-free DNA levels in patients undergoing cardiac surgery: Possible contribution of neutrophil extracellular traps to perioperative renal dysfunction

Anesthesiology Research and Practice
  • Yu Qi
  • ,
  • Tokujiro Uchida
  • ,
  • Mamoru Yamamoto
  • ,
  • Yudai Yamamoto
  • ,
  • Koji Kido
  • ,
  • Hiroyuki Ito
  • ,
  • Nagara Ohno
  • ,
  • Miho Asahara
  • ,
  • Yoshitsugu Yamada
  • ,
  • Osamu Yamaguchi
  • ,
  • Chieko Mitaka
  • ,
  • Makoto Tomita
  • ,
  • Koshi Makita

2016
開始ページ
2794364
終了ページ
記述言語
掲載種別
研究論文(学術雑誌)
DOI
10.1155/2016/2794364

© 2016 Yu Qi et al. Background. This study aimed to determine the perioperative change in serum double-strand DNA (dsDNA) as a marker potentially reflecting neutrophil extracellular trap concentration in samples from patients undergoing cardiac surgery and to analyze a relationship between serum dsDNA concentrations and perioperative renal dysfunction. Methods. Serum dsDNA concentrations in samples that were collected during a previously conducted, prospective, multicenter, observational study were measured. Eighty patients undergoing elective cardiac surgery were studied. Serum samples were collected at baseline, immediately after surgery, and the day after surgery (POD-1). Results. Serum dsDNA concentration was significantly increased from baseline (median, 398 ng/mL [interquartile range, 372-475 ng/mL]) to immediately after surgery (median, 540 ng/mL [437-682 ng/mL], p < 0.001), and they were reduced by POD-1 (median, 323 ng/mL [256-436 ng/mL]). The difference in serum creatinine concentration between baseline and POD-1 was correlated with dsDNA concentration on POD-1 (r s = 0.61, p < 0.001). Conclusions. In patients undergoing cardiac surgery, serum dsDNA concentration is elevated postoperatively. Prolonged elevation in dsDNA concentration is correlated with perioperative renal dysfunction. Further large-scale studies are needed to determine the relationship between serum concentration of circulating dsDNA and perioperative renal dysfunction.

リンク情報
DOI
https://doi.org/10.1155/2016/2794364
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27882047
Scopus
https://www.scopus.com/record/display.uri?eid=2-s2.0-84996614684&origin=inward
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