MISC

査読有り
2017年2月

The Roles of the Olivocerebellar Pathway in Motor Learning and Motor Control. A Consensus Paper

CEREBELLUM
  • Eric J. Lang
  • Richard Apps
  • Fredrik Bengtsson
  • Nadia L. Cerminara
  • Chris I. De Zeeuw
  • Timothy J. Ebner
  • Detlef H. Heck
  • Dieter Jaeger
  • Henrik Jorntell
  • Mitsuo Kawato
  • Thomas S. Otis
  • Ozgecan Ozyildirim
  • Laurentiu S. Popa
  • Alexander M. B. Reeves
  • Nicolas Schweighofer
  • Izumi Sugihara
  • Jianqiang Xiao
  • 全て表示

16
1
開始ページ
230
終了ページ
252
記述言語
英語
掲載種別
記事・総説・解説・論説等(学術雑誌)
DOI
10.1007/s12311-016-0787-8
出版者・発行元
SPRINGER

For many decades, the predominant view in the cerebellar field has been that the olivocerebellar system's primary function is to induce plasticity in the cerebellar cortex, specifically, at the parallel fiber-Purkinje cell synapse. However, it has also long been proposed that the olivocerebellar system participates directly in motor control by helping to shape ongoing motor commands being issued by the cerebellum. Evidence consistent with both hypotheses exists; however, they are often investigated as mutually exclusive alternatives. In contrast, here, we take the perspective that the olivocerebellar system can contribute to both the motor learning and motor control functions of the cerebellum and might also play a role in development. We then consider the potential problems and benefits of it having multiple functions. Moreover, we discuss how its distinctive characteristics (e.g., low firing rates, synchronization, and variable complex spike waveforms) make it more or less suitable for one or the other of these functions, and why having multiple functions makes sense from an evolutionary perspective. We did not attempt to reach a consensus on the specific role(s) the olivocerebellar system plays in different types of movements, as that will ultimately be determined experimentally; however, collectively, the various contributions highlight the flexibility of the olivocerebellar system, and thereby suggest that it has the potential to act in both the motor learning and motor control functions of the cerebellum.

リンク情報
DOI
https://doi.org/10.1007/s12311-016-0787-8
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27193702
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000393586100023&DestApp=WOS_CPL
ID情報
  • DOI : 10.1007/s12311-016-0787-8
  • ISSN : 1473-4222
  • eISSN : 1473-4230
  • PubMed ID : 27193702
  • Web of Science ID : WOS:000393586100023

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