Nobuyuki Kakiuchi

Profile Information

Affiliation: Kyoto University

ORCID ID: https://orcid.org/0000-0003-4893-5414
J-GLOBAL ID: 201901008075545068
researchmap Member ID: B000361781

Research Areas

Papers

101

RNA-seq-based miRNA signature as an independent predictor of relapse in pediatric B-cell acute lymphoblastic leukemia

Hirohito Kubota, Hiroo Ueno, Keiji Tasaka, Tomoya Isobe, Satoshi Saida, Itaru Kato, Katsutsugu Umeda, Mitsuteru Hiwatari, Daiichiro Hasegawa, Toshihiko Imamura …

Blood Advances, Dec 21, 2023
Single Nucleotide Polymorphisms of the MEFV Gene E148Q Are Highly Associated With Disease Phenotype in Crohn's Disease.

Satoshi Yamada, Yusuke Honzawa, Shuji Yamamoto, Minoru Matsuura, Hiroki Kitamoto, Makoto Okabe, Nobuyuki Kakiuchi, Takahiko Toyonaga, Taku Kobayashi, Toshifumi Hibi …

Inflammatory bowel diseases, Nov 10, 2023
前立腺における多段階発癌の遺伝子解析(Genetic analysis of multi-step carcinogenesis in the prostate)

日紫喜公輔, 垣内伸之, 寺本祐記, 北悠希, 木村啓佑, 渡部光一, 山中利之, 家入康輔, 前田紘奈, 西村友美 …

日本癌学会総会記事, 82回 1307-1307, Sep, 2023
Anti-integrin αvβ6 autoantibodies in patients with primary sclerosing cholangitis.

Hiroyuki Yoshida, Masahiro Shiokawa, Takeshi Kuwada, Yuya Muramoto, Sakiko Ota, Yoshihiro Nishikawa, Hirona Maeda, Nobuyuki Kakiuchi, Kanako Okamoto, Hajime Yamazaki …

Journal of gastroenterology, 58(8) 778-789, Aug, 2023
Evolutionary histories of breast cancer and related clones.

Tomomi Nishimura, Nobuyuki Kakiuchi, Kenichi Yoshida, Takaki Sakurai, Tatsuki R Kataoka, Eiji Kondoh, Yoshitsugu Chigusa, Masahiko Kawai, Morio Sawada, Takuya Inoue …

Nature, 620(7974) 607-614, Jul 26, 2023
Post-azacitidine clone size predicts outcome of patients with myelodysplastic syndromes and related myeloid neoplasms.

Yasuhito Nannya, Magnus Tobiasson, Shinya Sato, Elsa Bernard, Shigeki Ohtake, June Takeda, Maria Creignou, Lanying Zhao, Manabu Kusakabe, Yuhei Shibata …

Blood advances, Mar 29, 2023 Peer-reviewed
On the origin of gastric tumours: analysis of a case with intramucosal gastric carcinoma and oxyntic gland adenoma.

Ken Kumagai, Takahiro Shimizu, Mitsuhiro Nikaido, Tomonori Hirano, Nobuyuki Kakiuchi, Yasuhide Takeuchi, Sachiko Minamiguchi, Takaki Sakurai, Mari Teramura, Takahiro Utsumi …

The Journal of pathology, 259(4) 362-368, Jan 10, 2023
Germline DDX41 mutations define a unique subtype of myeloid neoplasms.

Hideki Makishima, Ryunosuke Saiki, Yasuhito Nannya, Sophia Claire Korotev, Carmelo Gurnari, June Takeda, Yukihide Momozawa, Steven Best, Pramila Krishnamurthy, Tetsuichi Yoshizato …

Blood, 141(5) 534-549, Nov 2, 2022 Peer-reviewed
大腸癌におけるトランスレーショナルリサーチの新たな展開大腸癌の分子分類および予後予測リスク分類(Molecular classification and risk stratification of colorectal cancer)

井上善景, 垣内伸之, 南谷泰仁, 吉田健一, 竹内康英, 藤井陽一, 千葉健一, 吉里哲一, 長山聡, 宮野悟 …

日本癌学会総会記事, 81回 SST4-6, Sep, 2022
正常およびがん組織におけるクローン進化乳管上皮細胞から乳癌へ至るクローン進化(Clonal evolution of mammary epithelial cells into breast cancers)

西村友美, 垣内伸之, 吉田健一, 桜井孝規, 片岡竜貴, 澤田守男, 竹内康英, 前田紘奈, 馬場郷子, 滝田順子 …

日本癌学会総会記事, 81回 S23-5, Sep, 2022
同時性・異時性多発膵癌の遺伝子解析(Genetic analysis of synchronous or metachronous multiple pancreatic cancers)

平野智紀, 垣内伸之, 竹内康英, 増井俊彦, 白石友一, 宮野悟, 宇座徳光, 児玉裕三, 増田充弘, 田中雄志

日本癌学会総会記事, 81回 P-3214, Sep, 2022
骨髄系腫瘍におけるDDX41胚細胞変異・体細胞変異の分子病態の解明(Elucidating the mechanism of clonal evolution of DDX41 mutated cells in myeloid malignancies)

昆彩奈, 中川正宏, 片岡圭亮, 垣内伸之, 牧島秀樹, 越智陽太郎, 中山学, 古関明彦, 南谷泰仁, 小川誠司

日本癌学会総会記事, 81回 E-1066, Sep, 2022
単一細胞マルチオミクス解析によるクローン性造血の病態解明(Distinct pathogenesis of clonal hematopoiesis revealed by single-cell multi-omics sequencing)

中川正宏, 稲垣良作, 南谷泰仁, 佐伯龍之介, 越智陽太郎, 竹田淳恵, 趙蘭英, 威星星, 依田成玄, 昆彩奈 …

日本癌学会総会記事, 81回 IS8-6, Sep, 2022
A novel SREBF1::NACC1 gene fusion in a unclassifiable intracranial tumour.

Yasuhide Takeuchi, Yohei Mineharu, Yoshiki Arakawa, Masayuki Hara, Yuki Oichi, Takahiko Kamata, Keita Fukuyama, Yoshihiro Yamamoto, Toshiyuki Yamanaka, Nobuyuki Kakiuchi …

Neuropathology and applied neurobiology, 48(7) e12843, Jul 28, 2022
Genetic analysis of pheochromocytoma and paraganglioma complicating cyanotic congenital heart disease.

Tatsuki Ogasawara, Yoichi Fujii, Nobuyuki Kakiuchi, Yusuke Shiozawa, Ryuichi Sakamoto, Yoshihiro Ogawa, Katsuki Ootani, Etsuro Ito, Tomoaki Tanaka, Kenichiro Watanabe …

The Journal of clinical endocrinology and metabolism, 107(9) 2545-2555, Jun 22, 2022
正常乳管上皮細胞から乳癌に至るクローン進化

西村友美, 垣内伸之, 吉田健一, 竹内康英, 前田紘奈, 南谷泰仁, 塩澤裕介, 中川正宏, 越智陽太郎, 佐伯龍之介 …

日本乳癌学会総会プログラム抄録集, 30回 OS7-1, Jun, 2022
正常乳管上皮細胞から乳癌に至るクローン進化

西村友美, 垣内伸之, 吉田健一, 竹内康英, 前田紘奈, 南谷泰仁, 塩澤裕介, 中川正宏, 越智陽太郎, 佐伯龍之介 …

日本乳癌学会総会プログラム抄録集, 30回 OS7-1, Jun, 2022
Expansion of Gastric Intestinal Metaplasia with Copy Number Aberrations Contributes to Field Cancerization.

Ken Kumagai, Takahiro Shimizu, Atsushi Takai, Nobuyuki Kakiuchi, Yasuhide Takeuchi, Tomonori Hirano, Haruhiko Takeda, Aya Mizuguchi, Mari Teramura, Takahiko Ito …

Cancer research, 82(9) 1712-1723, May 3, 2022
The landscape of genetic aberrations in myxofibrosarcoma.

Yasuhide Takeuchi, Kenichi Yoshida, Adriane Halik, Annegret Kunitz, Hiromichi Suzuki, Nobuyuki Kakiuchi, Yusuke Shiozawa, Akira Yokoyama, Yoshikage Inoue, Tomonori Hirano …

International journal of cancer, 151(4) 565-577, Apr 29, 2022
Whole-genome landscape of adult T-cell leukemia/lymphoma

Yasunori Kogure, Takuro Kameda, Junji Koya, Makoto Yoshimitsu, Kisato Nosaka, Jun ichirou Yasunaga, Yoshitaka Imaizumi, Mizuki Watanabe, Yuki Saito, Yuta Ito …

Blood, 139(7) 967-982, Feb 17, 2022

Misc.

Genetic analysis of metachronous pancreatic cancers

Tomonori Hirano, Nobuyuki Kakiuchi, Yasuhide Takeuchi, Toshihiko Masui, Shinji Uemoto, Sachiko Minamiguchi, Hironori Haga, Yuichi Shiraishi, Satoru Miyano, Norimitsu Uza …

CANCER SCIENCE, 112 658-658, Feb, 2021
Clonal evolution of proliferative lesions into breast cancers

Tomomi Nishimura, Nobuyuki Kakiuchi, Kenichi Yoshida, Yasuhide Takeuchi, Hirona Maeda, Yusuke Shiozawa, Masahiro Hirata, Tatsuki R. Kataoka, Takaki Sakurai, Satoko Baba …

CANCER SCIENCE, 112 157-157, Feb, 2021
Early Clonal evolution of myeloid malignancies

Masahiro Nakagawa, Ryosaku Inagaki, Yasuhito Nannya, Lanying Zhao, Yotaro Ochi, June Takeda, Xingxing Qi, Akinori Yoda, Ayana Kon, Nobuyuki Kakiuchi …

CANCER SCIENCE, 112 969-969, Feb, 2021
Frequent abnormalities in TP53 and increased genetic instability in myxofibrosarcoma

Yasuhide Takeuchi, Hiromichi Suzuki, Kenichi Yoshida, Yuichi Shiraishi, Nobuyuki Kakiuchi, Yusuke Shiozawa, Yoshikage Inoue, Kenichi Chiba, Hideki Makishima, Satoru Miyano …

CANCER SCIENCE, 112 850-850, Feb, 2021
変異と発現のマルチオミクス単一細胞解析によって明らかにされたクローン造血における初期変異細胞の有する非細胞自律性作用

中川正宏, 稲垣良作, 南谷泰仁, 趙蘭英, 趙蘭英, 越智陽太郎, 竹田淳恵, 戚星星, 依田成玄, 昆彩奈 …

日本癌学会学術総会抄録集(Web), 80th, 2021
Clinical Impacts of Germline DDX41 Mutations on Myeloid Neoplasms

Hideki Makishima, Yasuhito Nannya, June Takeda, Yukihide Momozawa, Ryunosuke Saiki, Tetsuichi Yoshizato, Yoshiko Atsuta, Yuka Iijima-Yamashita, Kenichi Yoshida, Yuichi Shiraishi …

BLOOD, 136, Nov, 2020
Distinct Pathogenesis of Clonal Hematopoiesis Revealed By Single Cell RNA Sequencing Integrated with Highly Sensitive Genotyping Method

Masahiro Marshall Nakagawa, Ryosaku Inagaki, Yutaka Kuroda, Yasuhito Nannya, Lanying Zhao, Yotaro Ochi, June Takeda, Qi Xingxing, Akinori Yoda, Ayana Kon …

BLOOD, 136, Nov, 2020
Analysis of clonal expansion in epithelium affected by ulcerative colitis reveals frequent mutations affecting IL-17 signaling pathway and novel cancer vulnerability

Nobuyuki Kakiuchi, Kenichi Yoshida, Motoi Uchino, Takako Kihara, Akaki Kotaro, Yoshikage Inoue, Kenji Kawada, Satoshi Nagayama, Akira Yokoyama, Tomonori Hirano …

CANCER RESEARCH, 80(16), Aug, 2020
Frequent abnormalities in TP53 and increased genetic instability in myxofibrosarcoma

Yasuhide Takeuchi, Annegret Kunitz, Adriane Halik, Hiromichi Suzuki, Kenichi Yoshida, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Nobuyuki Kakiuchi, Yusuke Shiozawa …

CANCER RESEARCH, 80(16), Aug, 2020
Genetic analysis of metachronous pancreatic cancers

Hirano Tomonori, Nobuyuki Kakiuchi, Yasuhide Takeuchi, Yoshikage Inoue, Tomomi Nishimura, Yoichi Fujii, Akira Yokoyama, Hideki Makishima, Toshihiko Masui, Shinji Uemoto …

CANCER RESEARCH, 80(16), Aug, 2020
Tissue remodeling by positively selected clones in esophagus and colon

垣内伸之, 垣内伸之, 横山顕礼, 内野基, 木原多佳子, 赤木宏太朗, 井上善景, 平野智紀, 平野智紀, 廣田誠一 …

日本癌学会学術総会抄録集(Web), 79th, 2020
単一細胞でのRNA/DNA同時シーケンスによるクローン造血の病態解明

中川正宏, 中川正宏, 稲垣良作, 稲垣良作, 稲垣良作, 黒田隆, 南谷泰仁, 趙蘭英, 趙蘭英, 越智陽太郎 …

日本血液学会学術集会抄録(Web), 82nd, 2020
Clonal expansion in bile duct associated with chronic inflammation

前田紘奈, 前田紘奈, 垣内伸之, 平野智紀, 平野智紀, 竹内康英, 竹内康英, 伊藤孝司, 小川絵里, 塩川雅広 …

日本癌学会学術総会抄録集(Web), 79th, 2020
Frequent mutational alterations to evade the immune system in colorectal cancer with POLE gene mutation

井上善景, 垣内伸之, 吉田健一, 塩澤裕介, 竹内康英, 竹内康英, 千葉健一, 吉里哲一, 長山聡, 宮野悟 …

日本癌学会学術総会抄録集(Web), 79th, 2020
Clonal evolution of non-malignant proliferative lesions into breast cancers

Tomomi Nishimura, Kenichi Yoshida, Yukiko Kawata, Yasuhide Takeuchi, Nobuyuki Kakiuchi, Yusuke Shiozawa, Kosuke Aoki, Masahiro Hirata, Tatsuki R. Kataoka, Takaki Sakurai …

CANCER RESEARCH, 79(13), Jul, 2019
Myxofibrosarcoma is characterized by frequent abnormalities in TP53 and increased genetic instability

Yasuhide Takeuchi, Annegret Kunitz, Hiromichi Suzuki, Kenichi Yoshida, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Teppei Shimamura, Nobuyuki Kakiuchi, Yusuke Shiozawa …

CANCER RESEARCH, 79(13), Jul, 2019
Chronology and risk dependence of age-related remodelling of oesophageal epithelia

Akira Yokoyama, Nobuyuki Kakiuchi, Tetsuichi Yoshizato, Yasuhito Nannya, Hiromichi Suzuki, Yasuhide Takeuchi, Yusuke Shiozawa, Yusuke Sato, Kosuke Aoki, Soo Kim …

CANCER RESEARCH, 79(13), Jul, 2019
膵神経内分泌腫瘍の病理とバイオマーカー膵神経内分泌癌の網羅的ゲノム解析

垣内伸之, 宇座徳光, 細田和貴, 谷田部恭, 桑原崇通, 水野伸匡, 児玉裕三, 妹尾浩, 小川誠司

膵臓, 34(3) A63-A63, Jun, 2019
膵神経内分泌癌の網羅的ゲノム解析

垣内伸之, 宇座徳光, 細田和貴, 谷田部恭, 桑原崇通, 水野伸匡, 児玉裕三, 妹尾浩, 小川誠司

膵臓(Web), 34(3), 2019
潰瘍性大腸炎における上皮細胞の陽性選択

垣内伸之, 垣内伸之, 内野基, 木原多佳子, 赤木宏太朗, 井上善景, 長山聡, 横山顕礼, 平野智紀, 平野智紀 …

日本分子生物学会年会プログラム・要旨集(Web), 42nd, 2019

Research Projects

Investigation of development mechanism and preemptive medicine for IDH-mutant glioma based on genomic analysis of normal brain tissues

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2026
食道がん化における初期のゲノム異常の解明-多発ヨード不染の網羅的ゲノム解析-

科学研究費助成事業, 基盤研究(B), 日本学術振興会, Apr, 2020 - Mar, 2023

横山顕礼, 玉置将司, 小川誠司, 垣内伸之
Deciphering colorectal carcinogenesis by the genomic analysis of colorectal epithelial cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2020 - Mar, 2023
Study on pathogenesis and cancer development in primary sclerosing cholangitis by genetic analysis of biliary epithelium

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Research (Exploratory), Japan Society for the Promotion of Science, Jul, 2020 - Mar, 2022

Kakiuchi Nobuyuki

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