1993年8月
CLONING AND EXPRESSION OF A CDNA FOR THE RAT KAPPA-OPIOID RECEPTOR
FEBS LETTERS
- ,
- ,
- ,
- ,
- ,
- ,
- ,
- 巻
- 329
- 号
- 3
- 開始ページ
- 291
- 終了ページ
- 295
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/0014-5793(93)80240-U
- 出版者・発行元
- ELSEVIER SCIENCE BV
We cloned a cDNA for the rat kappa-opioid receptor from a rat thalamus cDNA library. The deduced amino acid sequence consists of 380 residues with features shared by members of the G protein-coupled receptor family. The specific binding of [H-3]bremazocine to the membrane of COS-7 cells transfected with the cDNA was displaced by kappa-specific opioid ligands, but not by mu- and delta-specific ligands. Xenopus oocytes injected with the in vitro transcribed mRNA responded to opioid ligands with the same subtype specificity. Northern blot analysis demonstrated that kappa-opioid receptor mRNA is expressed in a regionally specific manner in rat brain.
- リンク情報
-
- DOI
- https://doi.org/10.1016/0014-5793(93)80240-U
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=200902151176547162
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/8103466
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:A1993LV58400013&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-0027304903&partnerID=MN8TOARS
- URL
- http://orcid.org/0000-0001-5152-5809
- ID情報
-
- DOI : 10.1016/0014-5793(93)80240-U
- ISSN : 0014-5793
- J-Global ID : 200902151176547162
- ORCIDのPut Code : 25904703
- PubMed ID : 8103466
- SCOPUS ID : 0027304903
- Web of Science ID : WOS:A1993LV58400013