2017年9月
Quantitation of nasal development in the early prenatal period using geometric morphometrics and MRI: a new insight into the critical period of Binder phenotype
PRENATAL DIAGNOSIS
- 巻
- 37
- 号
- 9
- 開始ページ
- 907
- 終了ページ
- 915
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/pd.5106
- 出版者・発行元
- WILEY
ObjectivesDisturbance of the development of the nasal septum in the early prenatal period causes congenital facial anomalies characterized by a flat nose and defects of the anterior nasal spine (ANS), such as Binder phenotype. The present research aimed to assess the development of the nasal septum and the ANS with growth in the early prenatal period.
MethodsMagnetic resonance images were obtained from 56 specimens. Mid-sagittal images were analyzed by using geometric morphometrics for the development of the nasal septum, and angle analysis was performed for the development of the ANS. Additionally, we calculated and visualized the ontogenetic allometry of the nasal septum.
ResultsOur results showed that the nasal septum changed shape in the anteroposterior direction in smaller specimens, while it maintained an almost isometric shape in larger specimens. Furthermore, mathematical evidence revealed that the maturation periods of the shapes of the ANS and the nasal septum were around 12 and 14weeks of gestation, respectively.
ConclusionThe anteroposterior development of the nasal septum is specific until 14weeks of gestation, and it is important for nasal protrusion and the development of the ANS. Therefore, the disturbance of such development could induce low nasal deformity, including Binder phenotype. (c) 2017 John Wiley & Sons, Ltd.
MethodsMagnetic resonance images were obtained from 56 specimens. Mid-sagittal images were analyzed by using geometric morphometrics for the development of the nasal septum, and angle analysis was performed for the development of the ANS. Additionally, we calculated and visualized the ontogenetic allometry of the nasal septum.
ResultsOur results showed that the nasal septum changed shape in the anteroposterior direction in smaller specimens, while it maintained an almost isometric shape in larger specimens. Furthermore, mathematical evidence revealed that the maturation periods of the shapes of the ANS and the nasal septum were around 12 and 14weeks of gestation, respectively.
ConclusionThe anteroposterior development of the nasal septum is specific until 14weeks of gestation, and it is important for nasal protrusion and the development of the ANS. Therefore, the disturbance of such development could induce low nasal deformity, including Binder phenotype. (c) 2017 John Wiley & Sons, Ltd.
- リンク情報
- ID情報
-
- DOI : 10.1002/pd.5106
- ISSN : 0197-3851
- eISSN : 1097-0223
- Web of Science ID : WOS:000411085100008