Kenichiro Kinouchi

Profile Information

researchmap Member ID: B000345871

Research Areas

Life sciences / Metabolism and endocrinology /

Papers

Association Between Renal Sinus Fat and Cardiometabolic and Renin-Angiotensin System Parameters in Primary Aldosteronism.

Ryunosuke Mitsuno, Kenji Kaneko, Toshifumi Nakamura, Daiki Kojima, Yosuke Mizutani, Tatsuhiko Azegami, Shintaro Yamaguchi, Yoshitake Yamada, Masahiro Jinzaki, Kenichiro Kinouchi …

Journal of the Endocrine Society, 8(1) bvad154, Dec 1, 2023
Adipocyte NMNAT1 expression is essential for nuclear NAD+ biosynthesis but dispensable for regulating thermogenesis and whole-body energy metabolism.

Shintaro Yamaguchi, Daiki Kojima, Tooba Iqbal, Shotaro Kosugi, Michael P Franczyk, Nathan Qi, Yo Sasaki, Keisuke Yaku, Kenji Kaneko, Kenichiro Kinouchi …

Biochemical and biophysical research communications, 674 162-169, Sep 24, 2023
Intermittent Fasting Sustainably Improves Glucose Tolerance in Normal Weight Male Mice Through Histone Hyperacetylation.

Sho Endo, Asuka Uto, Kazutoshi Miyashita, Masaaki Sato, Hiroyuki Inoue, Kentaro Fujii, Aika Hagiwara, Masaki Ryuzaki, Takuma Oshida, Kenichiro Kinouchi …

Journal of the Endocrine Society, 7(7) bvad082, Jun 5, 2023
The circadian clock CRY1 regulates pluripotent stem cell identity and somatic cell reprogramming.

Shogo Sato, Tomoaki Hishida, Kenichiro Kinouchi, Fumiaki Hatanaka, Yumei Li, Quy Nguyen, Yumay Chen, Ping H Wang, Kai Kessenbrock, Wei Li …

Cell reports, 42(6) 112590-112590, May 31, 2023
Antibiotic-induced microbiome depletion remodels daily metabolic cycles in the brain.

Jacob G Smith, Tomoki Sato, Kohei Shimaji, Kevin B Koronowski, Paul Petrus, Marlene Cervantes, Kenichiro Kinouchi, Dominik Lutter, Kenneth A Dyar, Paolo Sassone-Corsi

Life sciences, 303 120601-120601, Aug 15, 2022
Chromatin Immunoprecipitation and Circadian Rhythms.

Kenichiro Kinouchi, Kazutoshi Miyashita, Hiroshi Itoh

Methods in molecular biology (Clifton, N.J.), 2482 341-351, 2022
DNA repair factor KAT5 prevents ischemic acute kidney injury through glomerular filtration regulation

Akihito Hishikawa, Kaori Hayashi, Akiko Kubo, Kazutoshi Miyashita, Akinori Hashiguchi, Kenichiro Kinouchi, Norifumi Yoshimoto, Ran Nakamichi, Riki Akashio, Erina Sugita …

iScience, 24(12) 103436-103436, Dec, 2021
Transient Dexamethasone Loading Induces Prolonged Hyperglycemia in Male Mice With Histone Acetylation in Dpp-4 Promoter.

Asuka Uto, Kazutoshi Miyashita, Sho Endo, Masaaki Sato, Masaki Ryuzaki, Kenichiro Kinouchi, Masanori Mitsuishi, Shu Meguro, Hiroshi Itoh

Endocrinology, 162(12), Dec 1, 2021
Pharmacokinetics of hydrogen after ingesting a hydrogen-rich solution: A study in pigs.

Genki Ichihara, Yoshinori Katsumata, Hidenori Moriyama, Hiroki Kitakata, Akeo Hirai, Mizuki Momoi, Seien Ko, Yoshiki Shinya, Kenichiro Kinouchi, Eiji Kobayashi …

Heliyon, 7(11) e08359, Nov, 2021 Peer-reviewed
Circadian rhythms in the tissue-specificity from metabolism to immunity: insights from omics studies.

Kenichiro Kinouchi, Yohei Mikami, Takanori Kanai, Hiroshi Itoh

Molecular aspects of medicine, 80 100984-100984, Aug, 2021
Activation of the intestinal tissue renin-angiotensin system by transient sodium loading in salt-sensitive rats.

Masaki Ryuzaki, Kazutoshi Miyashita, Masaaki Sato, Hiroyuki Inoue, Kentaro Fujii, Aika Hagiwara, Asuka Uto, Sho Endo, Takuma Oshida, Kenichiro Kinouchi …

Journal of hypertension, Jul 19, 2021
Combined Gene Expression and Chromatin Immunoprecipitation From a Single Mouse Hippocampus.

Jean-Christophe Helbling, Kenichiro Kinouchi, Pierre Trifilieff, Paolo Sassone-Corsi, Marie-Pierre Moisan

Current protocols, 1(2) e33, Feb, 2021
S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling.

Carolina Magdalen Greco, Marlene Cervantes, Jean-Michel Fustin, Kakeru Ito, Nicholas Ceglia, Muntaha Samad, Jiejun Shi, Kevin Brian Koronowski, Ignasi Forne, Suman Ranjit …

Science advances, 6(51), Dec, 2020
Reshaping circadian metabolism in the suprachiasmatic nucleus and prefrontal cortex by nutritional challenge.

Paola Tognini, Muntaha Samad, Kenichiro Kinouchi, Yu Liu, Jean-Christophe Helbling, Marie-Pierre Moisan, Kristin L Eckel-Mahan, Pierre Baldi, Paolo Sassone-Corsi

Proceedings of the National Academy of Sciences of the United States of America, 117(47) 29904-29913, Nov 24, 2020
Metabolic rivalry: circadian homeostasis and tumorigenesis.

Kenichiro Kinouchi, Paolo Sassone-Corsi

Nature reviews. Cancer, 20(11) 645-661, Nov, 2020
Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake.

Jonathan Gaucher, Kenichiro Kinouchi, Nicholas Ceglia, Emilie Montellier, Shahaf Peleg, Carolina Magdalen Greco, Andreas Schmidt, Ignasi Forne, Selma Masri, Pierre Baldi …

Proceedings of the National Academy of Sciences of the United States of America, 116(50) 25250-25259, Dec 10, 2019 Peer-reviewed
(Pro)renin receptor accelerates development of sarcopenia via activation of Wnt/YAP signaling axis.

Naohiro Yoshida, Jin Endo, Kenichiro Kinouchi, Hiroki Kitakata, Hidenori Moriyama, Masaharu Kataoka, Tsunehisa Yamamoto, Kohsuke Shirakawa, Satoshi Morimoto, Akira Nishiyama …

Aging cell, 18(5) e12991, Oct, 2019 Peer-reviewed
BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis.

Welz PS, Zinna VM, Symeonidi A, Koronowski KB, Kinouchi K, Smith JG, Guillén IM, Castellanos A, Crainiciuc G, Prats N …

Cell, 177(6) 1436-1447.e12, May, 2019 Peer-reviewed
Light Entrains Diurnal Changes in Insulin Sensitivity of Skeletal Muscle via Ventromedial Hypothalamic Neurons.

Aras E, Ramadori G, Kinouchi K, Liu Y, Ioris RM, Brenachot X, Ljubicic S, Veyrat-Durebex C, Mannucci S, Galié M …

Cell reports, 27(8) 2385-2398.e3, May, 2019 Peer-reviewed
Nutrient-sensitive transcription factors TFEB and TFE3 couple autophagy and metabolism to the peripheral clock.

Pastore N, Vainshtein A, Herz NJ, Huynh T, Brunetti L, Klisch TJ, Mutarelli M, Annunziata P, Kinouchi K, Brunetti-Pierri N …

The EMBO journal, May, 2019 Peer-reviewed

Misc.

(プロ)レニン受容体の細胞内構造と機能

木内謙一郎, 市原淳弘, 越智広樹, 福田亨, 木田可奈子, 和田戈虹, 和田洋, 竹田秀, 伊藤裕

日本内分泌学会雑誌, 89(1) 234-234, Apr, 2013
V-ATPaseのassemblyにおける(プロ)レニン受容体の各ドメインとfurinによる切断の役割

木内謙一郎, 市原淳弘, 木田可奈子, 和田戈虹, 和田洋, 伊藤裕

日本腎臓学会誌, 55(3) 398-398, Apr, 2013
細胞内における(プロ)レニン受容体の構造と機能

木内謙一郎, 市原淳弘, 越智広樹, 福田亨, 砂村聡子, 木田可奈子, 黒澤秀章, 和田戈虹, 和田洋, 竹田秀 …

日本高血圧学会総会プログラム・抄録集, 35回 441-441, Sep, 2012
Current, knowledge about (pro)renin receptor/ATP6AP2

KINOUCHI Kenichiro, ICHIHARA Atsuhiro, ITOH Hiroshi

34(4) 159-166, Dec 31, 2011
Physiological Roles of (pro)renin Receptor/atp6ap2 in Vascular Smooth Muscle Cells

Asako Mito, Atsuhiro Ichihara, Kanako Bokuda, Kenichiro Kinouchi, Hideaki Kurosawa, Hiroshi Itoh

HYPERTENSION, 58(5) E88-E88, Nov, 2011
(Pro)renin Receptor is Essential for Expression of Slit Diaphragm Proteins in Murine Podocytes

Kenichiro Kinouchi, Atsuhiro Ichihara, Yoichi Oshima, Asako Kurauchi-Mito, Hideaki Kurosawa, Ge-Hong Sun-Wada, Yoh Wada, Taketo Yamada, Minoru Takemoto, Moin A. Saleem …

HYPERTENSION, 58(5) E55-E56, Nov, 2011
腎糸球体上皮細胞発達生命維持における(プロ)レニン受容体の必須な役割

木内謙一郎, 大島洋一, 市原淳弘, 和田戈虹, 和田洋, 三戸麻子, 木田可奈子, 黒澤秀章, 竹本稔, サリーム・モイン …

日本腎臓学会誌, 53(3) 394-394, May, 2011
X染色体上で調節される心筋細胞(プロ)レニン受容体の生理的機能

木内謙一郎, 市原淳弘, 佐野元昭, 和田戈虹, 和田洋, 三戸麻子, 木田可奈子, 黒澤秀章, 大島洋一, 福田恵一 …

日本内分泌学会雑誌, 87(1) 291-291, Apr, 2011
Contribution of (Pro)renin Receptor to the Development of Nephropathy in Diabetic Stroke-Prone Spontaneously Hypertensive Rats

Yasufumi Seki, Atsuhiro Ichihara, Yuki Mizuguchi, Mariyo Sakoda, Asako Mito, Tatsuya Narita, Kenichiro Kinouchi, Akira Nishiyama, Hiroshi Itoh

CLINICAL AND EXPERIMENTAL HYPERTENSION, 33(1) 21-21, 2011
Renoprotective Effects of Mineralocorticoid Receptor Blockade in Hemi-Nephrectomized (Pro)renin-Receptor-Transgenic Rats

Yuki Mizuguchi, Atsuhiro Ichihara, Yasufumi Seki, Mariyo Sakoda, Asako Kurauchi-Mito, Tatsuya Narita, Kenichiro Kinouchi, Kanako Bokuda, Hiroshi Itoh

CLINICAL AND EXPERIMENTAL HYPERTENSION, 33(1) 24-24, 2011
細胞内酸性環境を維持する(プロ)レニン受容体の生理的な機能

木内謙一郎, 市原淳弘, 佐野元昭, 和田戈虹, 和田洋, 三戸麻子, 木田可奈子, 成田達也, 大島洋一, 黒澤秀章 …

血管, 34(1) 32-32, Jan, 2011
Cardiomyocyte-specific Ablation of (Pro)renin Receptor Caused Fulminant Heart Failure Due To Disruption of Intracellular Acidification.

Kenichiro Kinouchi, Atsuhiro Ichihara, Motoaki Sano, Ge-Hong Sun-Wada, Yoh Wada, Asako Kurauchi-Mito, Kanako Bokuda, Tatsuya Narita, Yoichi Oshima, Mariyo Sakoda …

CIRCULATION, 122(21), Nov, 2010
心筋細胞特異的(プロ)レニン受容体ノックアウトマウスの解析

木内謙一郎, 市原淳弘, 佐野元昭, 和田戈虹, 和田洋, 三戸麻子, 木田可奈子, 成田達也, 大島洋一, 迫田万理代 …

日本高血圧学会総会プログラム・抄録集, 33回 233-233, Oct, 2010
Long-term treatment with handle region peptide inhibits the development of glomerulosclerosis in the non-clipped kidney of two-kidneys, one-clip Goldblatt hypertension

Masaki Ryuzaki, Atsuhiro Ichihara, Yoichi Oshima, Mariyo Sakoda, Asako Kurauchi-Mito, Tatsuya Narita, Kenichiro Kinouchi, Kanako Bokuda, Akira Nishiyama, Hiroshi Itoh

ENDOCRINE JOURNAL, 57 S558-S559, Mar, 2010
Tissue-specific (pro)renin receptor knockout mice

Atsuhiro Ichihara, Kenichiro Kinouchi, Yoichi Ohshima, Asako Kurauchi-Mito, Kanako Bokuda, Tatsuya Narita, Mariyo Sakoda, Hiroshi Itoh

ENDOCRINE JOURNAL, 57 S267-S267, Mar, 2010
Contribution of (pro)renin receptor to the development of insulin resistance in obese hypertensive rats

Tadashi Kamayachi, Atsuhiro Ichihara, Mariyo Sakoda, Asako Kurauchi-Mito, Tatsuya Narita, Kenichiro Kinouchi, Kanako Bokuda, Hiroo Kumagai, Hiroshi Itoh

ENDOCRINE JOURNAL, 57 S424-S424, Mar, 2010
Long-Term Infusion of Handle-Region Peptide (HRP) Inhibits Development of Glomerulosclerosis in the Nonclipped Kidney of 2-Kidney, 1-Clip (2K1C) Goldblatt Hypertensive Rats

Masaki Ryuzaki, Yoichi Ohshima, Mariyo Sakoda, Asako Kurauchi-Mito, Tatsuya Narita, Kenichiro Kinouchi, Kanako Murohashi-Bokuda, Akira Nishiyama, Hiroshi Itoh, Atsuhiro Ichihara

HYPERTENSION, 54(4) E89-E89, Oct, 2009
Involvement of Angiotensin II Generation and Intracellular Signal Transduction by (Pro)renin Receptor in Cardiac Hypertrophy of Diabetic Spontaneous Hypertensive Rats Complicated with Diabetes

Y. Seki, A. Ichihara, M. Sakoda, Y. Mizuguchi, A. Mito, T. Narita, K. Kinouchi, A. Nishiyama, H. Itoh

CLINICAL AND EXPERIMENTAL HYPERTENSION, 31(6) 498-498, 2009
REGULTATION OF (PRO)RENIN RECEPTOR EXPRESSION BY MECHANICAL STRETCH IN HUMAN PODOCYTES

Mariyo Sakoda, Atsuhiro Ichihara, Asako Kurauchi-Mito, Tatsuya Narita, Kenichiro Kinouchi, Moin A. Saleem, Hiroshi Itoh

JOURNAL OF PHYSIOLOGICAL SCIENCES, 59 483-483, 2009
Development of renin inhibitor and its benefits

Atsuhiro Ichihara, Mariyo Sakoda, Asako Mito, Tatsuya Narita, Kenichiro Kinouchi, Hiroshi Itoh

JOURNAL OF PHARMACOLOGICAL SCIENCES, 109 17P-17P, 2009

Research Projects

母児概日リズム同期と次世代疾患感受性の多層多元的代謝リズムパネルからの理解

科学研究費助成事業, 挑戦的研究(開拓), 日本学術振興会, Jul, 2021 - Mar, 2026

伊藤裕, 入江潤一郎, 宮下和季, 木内謙一郎
Dissecting the transcriptional network of organogenesis based on reprogramming factors

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2022 - Mar, 2025
脂肪組織血管新生能を標的とした血管内皮NAD賦活化による肥満2型糖尿病発症予防

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2025

山口慎太郎, 本間康一郎, 木内謙一郎
Development of the strategy to improve sarcopenia in streptozotocin-treated mice by modulation of amino acids in the white muscle.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2021 - Mar, 2024
Circadian clock and proliferative metabolism in the intestinal T lymphocytes

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Kinouchi Kenichiro
心筋特異的(プロ)レニン受容体欠損により発症する心筋症の病態解明と標的治療の開発

科学研究費助成事業, 若手研究(B), 日本学術振興会, 2010 - 2010

木内謙一郎

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