2014年9月11日
Significant roles of the (pro)renin receptor in integrity of vascular smooth muscle cells
Hypertension Research
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- 巻
- 37
- 号
- 9
- 開始ページ
- 830
- 終了ページ
- 835
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1038/hr.2014.92
- 出版者・発行元
- Japanese Society of Hypertension
The (pro)renin receptor ((P)RR) is known to play an important role in the pathogenesis of vascular complications in diabetes mellitus and hypertension through its function in activating the local renin-Angiotensin system. Recent studies have shown that the (P)RR is an accessory protein of the vacuolar H + -ATPase, suggesting a more fundamental and developmental function. In this study, smooth muscle cell-specific (P)RR/Atp6ap2 conditional knockout mice were generated. Smooth muscle cell-specific ablation of the (P)RR resulted in nonatherogenic sclerosis in the abdominal aorta. The deletion of the (P)RR did not affect ambulatory blood pressure levels. In cultured murine vascular smooth muscle cells (VSMCs), ablation of the (P)RR suppressed the expression of the Vo subunit c of the vacuolar H + -ATPase and impaired the cell recycling system, leading to autophagic cell death. In addition, loss of the (P)RR in VSMCs induced the expression of monocyte chemotactic protein-1 and interleukin-6 mRNAs. These results suggest that the (P)RR is essential for cell survival and downregulation of vascular inflammation in murine VSMCs through maintaining normal function of the vacuolar H + -ATPase. copy
2014 The Japanese Society of Hypertension All rights reserved.
2014 The Japanese Society of Hypertension All rights reserved.
- ID情報
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- DOI : 10.1038/hr.2014.92
- ISSN : 1348-4214
- ISSN : 0916-9636
- PubMed ID : 24830537
- SCOPUS ID : 84927164888