Kimie Date

Profile Information

Affiliation: Institute for Human Life Innovation, Ochanomizu University

Degree: 博士（理学）(Mar, 2012, お茶の水女子大学)

J-GLOBAL ID: 201801013993990801
researchmap Member ID: B000343971

Research Interests

Research Areas

Research History

Apr, 2021 - Present

Institute for Human Life Innovation, Ochanomizu University
Apr, 2017

Institute for Human Life Innovation, Ochanomizu University
Oct, 2015 - Oct, 2016

リサーチフェロー, 医学部, イェール大学
Apr, 2014

Ochanomizu University
Apr, 2012

Ochanomizu University
Apr, 2010

Ochanomizu University
Sep, 2005

正社員, 特許部門, 株式会社マネージメント総研
Apr, 2002

正社員, 創薬研究第一部, 中外製薬株式会社

Education

Oct, 2008 - Mar, 2012

Ochanomizu University
Apr, 2000 - Mar, 2002

Ochanomizu University
Apr, 1996 - Mar, 2000

Division of Chemistry, Faculty of Science, Ochanomizu University

Awards

Papers

Regulatory properties of vitronectin and its glycosylation in collagen fibril formation and collagen‑degrading enzyme cathepsin K activity

May, 2021 Peer-reviewedLead authorCorresponding author
Regulatory Functions of α-Amylase in the Small Intestine Other than Starch Digestion: α-Glucosidase Activity, Glucose Absorption, Cell Proliferation, and Differentiation

Kimie Date

New Insights Into Metabolic Syndrome [Working Title], May 28, 2020 Peer-reviewedLead authorCorresponding author
α‐Amylase expressed in human small intestinal epithelial cells is essential for cell proliferation and differentiation

Kimie Date, Tomomi Yamazaki, Yoko Toyoda, Kumi Hoshi, Haruko Ogawa

Journal of Cellular Biochemistry, 121(2) 1238-1249, Feb, 2020 Peer-reviewedLead authorCorresponding author
Vitronectins produced by human cirrhotic liver and CCl4‐treated rats differ in their glycosylation pattern and tissue remodeling activity

Kimie Date, Fumie Kano-Yajima, Kosuke Nakamura, Takahiro Ohtsuki, Hiroo Hoshino, Ken-ichi Tanamoto, Hiroshi Ushijima, Hiromi Sakagami, Haruko Ogawa

FEBS openbio, https://doi.org/10.1002/2211-5(open access article) 755-768, Apr, 2019 Peer-reviewedLead author
Preparation and Purification of Active Recombinant Human Pancreatic Lipase in Escherichia coli

Nanami Kawaguchi, Haruko Ogawa, Kimie Date

BIO-PROTOCOL, 9(13), 2019 Peer-reviewedLast authorCorresponding author
A novel protocol for the preparation of active recombinant human pancreatic lipase from Escherichia coli.

Nanami Kawaguchi, Kimie Date, Yusuke Suzuki, Chihiro Tomita, Rina Naradate, Tomoko Higami, Kosuke Nakamura, Kyoko Aikawa, Haruko Ogawa

The Journal of Biochemistry, 164(6) 407-414, Dec, 2018 Peer-reviewed
The pseudoproteoglycan probes synthesized by conjugating unsulfated dextran with poly-L-lysine exhibit anti-HIV-1 activity.

Kimie Date, Fumie Kano-Yajima, Kosuke Nakamura, Takahiro Ohtsuki, Hiroo Hoshino, Ken-ichi Tanamoto, Hiroshi Ushijima, Hiromi Sakagami, Haruko Ogawa

Current topics in Virology, 14 25-29, Dec, 2017 Peer-reviewedLead author
The serum protein renalase reduces injury in experimental pancreatitis

Thomas R. Kolodecik, Anamika M. Reed, Kimie Date, Christine A. Shugrue, Vikhil Patel, Shang-Lin Chung, Gary V. Desir, Fred S. Gorelick

JOURNAL OF BIOLOGICAL CHEMISTRY, 292(51) 21047-21059, Dec, 2017 Peer-reviewed
Sialylation of vitronectin regulates stress fiber formation and cell spreading of dermal fibroblasts via a heparin-binding site

Yasunori Miyamoto, Mio Tanabe, Kimie Date, Kanoko Sakuda, Kotone Sano, Haruko Ogawa

GLYCOCONJUGATE JOURNAL, 33(2) 227-236, Apr, 2016 Peer-reviewed
Carbohydrate-binding activities of coagulation factors fibrinogen and fibrin

Kimie Date, Mami Ohyama, Haruko Ogawa

GLYCOCONJUGATE JOURNAL, 32(6) 385-392, Aug, 2015 Peer-reviewedLead author
Pancreatic alpha-Amylase Controls Glucose Assimilation by Duodenal Retrieval through N-Glycan-specific Binding, Endocytosis, and Degradation

Kimie Date, Ayano Satoh, Kaoruko Iida, Haruko Ogawa

JOURNAL OF BIOLOGICAL CHEMISTRY, 290(28) 17439-17450, Jul, 2015 Peer-reviewedLead author
Autoactivation of pancreatic trypsinogen is controlled by carbohydrate-specific interaction

Haruko Ogawa, Izumi Kusumi, Aya Ogata, Arisa Wada, Hiromi Sakagami, Kana Mitsuhashi, Kimie Date

FEBS LETTERS, 589(5) 569-575, Feb, 2015 Peer-reviewedLast author
Glc Transporter Assay and the New Intestinal Glycobiology

Kimie Asanuma-Date, Haruko Ogawa

Glycoscience: Biology and Medicine, 99 1101-1110, Jan 1, 2015 Peer-reviewedLead author
二次元電気泳動で見出した低等電点をもつビトロネクチンの存在とそのヘパリン結合性の欠如

作田香子, 伊達公恵, 田邊美音, 宮本泰則, 小川温子

日本生化学会大会プログラム・講演要旨集, 87回 [3P-043], Oct, 2014
Glycans that affects health

Ogawa, H, Date, K

Seitoh Gikenshi, Oct, 2014 Peer-reviewed
Preparation of affinity adsorbents and purification of lectins from natural sources

Kimie Date, Haruko Ogawa

Methods in Molecular Biology, 1200 53-67, 2014 Peer-reviewedLead author
The "white kidney bean incident" in Japan

Haruko Ogawa, Kimie Date

Methods in Molecular Biology, 1200 39-45, 2014 Peer-reviewed
Immobilized glycosylated Fmoc-amino acid for SPR: comparative studies of lectin-binding to linear or biantennary diLacNAc structures

Kosuke Nakamura, Hiromi Sakagami, Kimie Asanuma-Date, Nao Nagasawa, Yoshiaki Nakahara, Hiroshi Akiyama, Haruko Ogawa

CARBOHYDRATE RESEARCH, 382(15) 77-85, Dec, 2013 Peer-reviewed
Functional Regulation of Sugar Assimilation by N-Glycan-specific Interaction of Pancreatic alpha-Amylase with Glycoproteins of Duodenal Brush Border Membrane

Kimie Asanuma-Date, Yuki Hirano, Na Le, Kotone Sano, Nana Kawasaki, Noritaka Hashii, Yoko Hiruta, Ken-ichi Nakayama, Mariko Umemura, Kazuhiko Ishikawa …

JOURNAL OF BIOLOGICAL CHEMISTRY, 287(27) 23104-23118, Jun, 2012 Peer-reviewedLead author
Matrix Restructuring During Liver Regeneration is Regulated by Glycosylation of the Matrix Glycoprotein Vitronectin

Haruko Ogawa, Kotone Sano, Naomi Sobukawa, Kimie Asanuma-Date

Liver Regeneration, May 16, 2012 Peer-reviewed

Misc.

膵トリプシン・トリプシノーゲンに見出したグリコサミノグリカン結合性

日比野明日香, 緒方彩, 和田有沙, 伊達公恵, 藤間祥子, 舘野浩章, 小川温子, 小川温子

日本糖質学会年会要旨集, 38th, 2019
Pancreatic alpha-amylase controls glucose assimilation in duodenum through N-glycan-specific binding, followed by endocytosis and degradation

Kimie Date, Ayano Satoh, Haruko Ogawa

GLYCOBIOLOGY, 24(11) 1185-1185, Nov, 2014
New Approach to Detect Changes in Sialylation of the Matrix Glycoprotein Vitronectin, which Regulates Matrix Restructuring During Liver Regeneration

Haruko Ogawa, Kotone Sano, Naomi Sobukawa, Kimie Asanuma-Date

GLYCOBIOLOGY, 22(11) 1568-1568, Nov, 2012
Carbohydrate-specific interaction of mammalian pancreatic alpha-amylases with glycoproteins on intestinal mucosa regulates glucose as similation for homeostasis

Kimie Date, Nana Kawasaki, Noritaka Hashii, Hiromi Sakagami, Haruko Ogawa

GLYCOBIOLOGY, 22(11) 1540-1540, Nov, 2012
肝再生時ラットビトロネクチンの部位特異的糖鎖修飾と組織再生を担う肝星細胞接着伸展に与える影響

佐野琴音, 宮本泰則, 川崎ナナ, 橋井則貴, 伊藤さつき, 村瀬美咲, 伊達公恵, 横山三紀, 佐藤ちひろ, 佐藤ちひろ …

生化学, 82(9), 2010

Books and Other Publications

細胞外マトリックス分子の糖鎖による肝再生の制御

伊達公恵, 佐野琴音, 小川温子 (Role: Joint author)

化学工業 Volume61, No.12, Dec, 2010
O-Linked Glycosylation on Focus

(Role: Joint translator)

2000
Dynamic Cytoskeletal Glycosylation and Neurodegenerative Disease

(Role: Joint translator)

1999

Research Projects

膵α-アミラーゼが認識するインスリン分泌制御糖タンパク質 DPP-4 の糖鎖構造と機能

平成30年度化学分野研究助成, 公益財団法人伊藤科学振興会, Oct, 2018 - Sep, 2023

伊達公恵
膵臓がんの検出・抑制に向けた, 膵酵素とがん特異糖鎖との相互作用解析

科学研究費助成事業若手研究, 若手研究, 日本学術振興会, Apr, 2019 - Mar, 2022

伊達公恵
食品成分による高血糖抑制機構の解明：腸内機能性糖鎖の制御による健康長寿

研究者育成助成〈ロッテ重光学術賞〉, 公益財団法人ロッテ財団, Apr, 2017 - Mar, 2022

伊達公恵
膵α-アミラーゼの腸内糖鎖リガンドを介する血糖値調節機構の解明とその制御

科研費（特別研究員奨励費）, Apr, 2014 - Mar, 2017

伊達公恵
DPP-4との相互作用解析が仲介する膵α‐アミラーゼのN-型糖鎖認識の役割

第1回（平成24年度）地神芳文記念研究助成金（糖質分野）, 酵母細胞研究会, Apr, 2013 - Mar, 2014

伊達公恵
膵臓酵素に見出した糖特異的結合性の分泌および消化吸収における意義

科研費（特別研究員奨励費）, Apr, 2011 - Mar, 2013

伊達公恵
膵α-アミラーゼと腸管レセプターの相互作用による血糖値調節の新機構

笹川科学研究助成金, 日本科学協会, Apr, 2010 - Mar, 2011

伊達公恵

Profile Information

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Research History

Education

Awards

Papers

Misc.

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