2014年5月
In vitro and in vivo anti-influenza virus activities of flavonoids and related compounds as components of Brazilian propolis (AF-08)
JOURNAL OF FUNCTIONAL FOODS
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- 巻
- 8
- 号
- 開始ページ
- 214
- 終了ページ
- 223
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.jff.2014.03.019
- 出版者・発行元
- ELSEVIER SCIENCE BV
We previously demonstrated that Brazilian propolis AF-08 exhibits anti-influenza virus activity in vitro and in vivo. To characterize its effective components, flavonoids and related compounds involved in AF-08 were examined for their anti-influenza virus activity in vitro and in vivo. Four flavonoids and three phenyl propanoids were selected as possible components of AF-08 by HPLC. Among them, apigenin, kaempferol, and coumaric acid exhibited significant antiviral activity against oseltamivir-and peramivir-sensitive and oseltamivir-and peramivir-resistant influenza viruses in plaque reduction assays and kaempferol did not interfere with virus adsorption and/or invasion in vitro. The oral administration of kaempferol was significantly effective in prolonging survival times and reducing virus titers in bronchoalveolar lavage fluids prepared from influenza virus-infected mice. Thus, kaempferol, a component of AF-08, exhibited therapeutic efficacy in limiting influenza symptoms in mice and is indicated to contribute to the in vivo anti-influenza virus activity of propolis AF-08 as a crude extract. (C) 2014 Elsevier Ltd. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.jff.2014.03.019
- ISSN : 1756-4646
- Web of Science ID : WOS:000336885100024