2017年9月
Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity.
Cancer immunology, immunotherapy : CII
- 巻
- 66
- 号
- 9
- 開始ページ
- 1131
- 終了ページ
- 1142
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s00262-017-2002-2
- 出版者・発行元
- SPRINGER
Neuropilin-1 (NRP-1)-expressing macrophages are engaged in antitumor immune functions via various mechanisms. In this study, we investigated the role of NRP-1 on macrophages in antibody-mediated tumoricidal activity. Treatment of macrophages with NRP-1 knockdown or an anti-NRP-1-neutralizing antibody significantly suppressed antibody-dependent cellular cytotoxicity and modulated cytokine secretion from macrophages in vitro. Furthermore, in vivo studies using a humanized mouse model bearing human epidermal growth factor receptor-2 (HER2)-positive breast cancer xenografts showed that antibody-mediated antitumor activity and tumor infiltration of CD4 T lymphocytes were significantly downregulated when peripheral blood mononuclear cells in which NRP-1 was knocked down were co-administered with an anti-HER2 antibody. These results revealed that NRP-1 expressed on macrophages plays an important role in antibody-mediated antitumor immunity. Taken together, the induction of NRP-1 on macrophages may be a therapeutic indicator for antibody treatments that exert antibody-dependent cellular cytotoxicity activity, although further studies are needed in order to support this hypothesis. +
- リンク情報
-
- DOI
- https://doi.org/10.1007/s00262-017-2002-2
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/28432397
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000408717200003&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-85018858353&partnerID=MN8TOARS
- Scopus Citedby
- https://www.scopus.com/inward/citedby.uri?partnerID=HzOxMe3b&scp=85018858353&origin=inward
- ID情報
-
- DOI : 10.1007/s00262-017-2002-2
- ISSN : 0340-7004
- eISSN : 1432-0851
- ORCIDのPut Code : 35929521
- PubMed ID : 28432397
- SCOPUS ID : 85018858353
- Web of Science ID : WOS:000408717200003