2020年11月
Anti-PM/Scl Antibody-positive Systemic Sclerosis Complicated by Multiple Organ Involvement
Internal medicine (Tokyo, Japan)
- 巻
- 60
- 号
- 7
- 開始ページ
- 1101
- 終了ページ
- 1107
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2169/internalmedicine.5665-20
- 出版者・発行元
- 一般社団法人 日本内科学会
A 40-year-old Japanese woman developed malignant-phase hypertension complicated by thrombotic microangiopathy, progressing to end-stage renal disease. Five years later, she was diagnosed with pulmonary arterial hypertension and interstitial pneumonia. Despite a lack of overt skin sclerosis, nucleolar staining in our indirect immunofluorescence analysis and nailfold capillaroscopy facilitated the diagnosis of anti-PM/Scl antibody-positive systemic sclerosis. We observed the persistent presence of anti-PM/Scl antibodies throughout the clinical course, suggesting that her kidney disease was scleroderma renal crisis. Anti-PM/Scl antibodies can be associated with multiple organ diseases. Careful attention to a patient's antinuclear antibody pattern and dermatological findings may help clarify the etiology of undiagnosed diseases.
- リンク情報
- ID情報
-
- DOI : 10.2169/internalmedicine.5665-20
- ISSN : 1349-7235
- PubMed ID : 33132335