2014年11月
Synthesis of beta-Lapachone, a Potential Anticancer Agent from the Lapacho Tree
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
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- 巻
- 号
- 32
- 開始ページ
- 7099
- 終了ページ
- 7103
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1002/ejoc.201403064
- 出版者・発行元
- WILEY-V C H VERLAG GMBH
A pharmaceutically important natural product, beta-lapachone, was efficiently synthesized in four steps in 70% overall yield starting from commercially available 1,4-naphthoquinone. The key step of the synthesis was the direct conversion of 2-prenyl-1,4-naphthoquinone into beta-lapachone through an advantageous cyclization/hydration/oxidation cascade process.
- リンク情報
- ID情報
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- DOI : 10.1002/ejoc.201403064
- ISSN : 1434-193X
- eISSN : 1099-0690
- Web of Science ID : WOS:000344624000005