MISC

2008年1月

Involvement of calcineurin in glutamate-induced mitochondrial dynamics in neurons

NEUROSCIENCE RESEARCH
  • Xiao-Jian Han
  • ,
  • Yun-Fei Lu
  • ,
  • Shun-Ai Li
  • ,
  • Kazuhito Tomizawa
  • ,
  • Kohji Takei
  • ,
  • Masayuki Matsushita
  • ,
  • Hideki Matsui

60
1
開始ページ
114
終了ページ
119
記述言語
英語
掲載種別
DOI
10.1016/j.neures.2007.09.012
出版者・発行元
ELSEVIER IRELAND LTD

Alterations in the morphology and movement of mitochondria influence neuronal viability. However, the precise mechanisms of such alterations are unclear. In this study, we showed calcineurin was involved in the regulation of mitochondrial dynamics. Glutamate stimulation inhibited mitochondrial movement and decreased mitochondrial length in neurons. FK506 and cyclosporine A, calcineurin inhibitors, attenuated the effects of glutamate on mitochondrial dynamics. It was also found that glutamate treatment dephosphorylated, a proapoptotic protein, Bad and promoted its translocation to mitochondria in neurons via calcineurin. These results provide important new insights into intracellular signaling pathways that regulate mitochondrial dynamics and neuronal cell death. (c) 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.


リンク情報
DOI
https://doi.org/10.1016/j.neures.2007.09.012
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000253089400013&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.neures.2007.09.012
  • ISSN : 0168-0102
  • Web of Science ID : WOS:000253089400013

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