2008年1月
Involvement of calcineurin in glutamate-induced mitochondrial dynamics in neurons
NEUROSCIENCE RESEARCH
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- 巻
- 60
- 号
- 1
- 開始ページ
- 114
- 終了ページ
- 119
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1016/j.neures.2007.09.012
- 出版者・発行元
- ELSEVIER IRELAND LTD
Alterations in the morphology and movement of mitochondria influence neuronal viability. However, the precise mechanisms of such alterations are unclear. In this study, we showed calcineurin was involved in the regulation of mitochondrial dynamics. Glutamate stimulation inhibited mitochondrial movement and decreased mitochondrial length in neurons. FK506 and cyclosporine A, calcineurin inhibitors, attenuated the effects of glutamate on mitochondrial dynamics. It was also found that glutamate treatment dephosphorylated, a proapoptotic protein, Bad and promoted its translocation to mitochondria in neurons via calcineurin. These results provide important new insights into intracellular signaling pathways that regulate mitochondrial dynamics and neuronal cell death. (c) 2007 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
- リンク情報
- ID情報
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- DOI : 10.1016/j.neures.2007.09.012
- ISSN : 0168-0102
- Web of Science ID : WOS:000253089400013