2020年3月31日
PHi-C: deciphering Hi-C data into polymer dynamics
NAR Genomics and Bioinformatics
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- 巻
- 2
- 号
- 2
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1093/nargab/lqaa020
Computational modelling methods for Hi-C data have revealed averaged and static features of the 3D genome in cell nuclei. Here, we describe a 4D simulation method, PHi-C (Polymer dynamics deciphered from Hi-C data), that depicts dynamic 3D genome features through polymer modelling. This method allows for demonstrations of dynamic characteristics of genomic loci and chromosomes, as observed in live-cell imaging experiments, and provides physical insights into Hi-C data.
- ID情報
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- DOI : 10.1093/nargab/lqaa020
- ISSN : 2631-9268
- ORCIDのPut Code : 71402170