論文

査読有り
2002年4月

Continuous exposure of mice to superantigenic toxins induces a high-level protracted expansion and an immunological memory in the toxin-reactive CD4(+) T cells

JOURNAL OF IMMUNOLOGY
  • LQ Chen
  • ,
  • M Koyanagi
  • ,
  • K Fukada
  • ,
  • K Imanishi
  • ,
  • J Yagi
  • ,
  • H Kato
  • ,
  • T Miyoshi-Akiyama
  • ,
  • RH Zhang
  • ,
  • K Miwa
  • ,
  • T Uchiyama

168
8
開始ページ
3817
終了ページ
3824
記述言語
英語
掲載種別
研究論文(学術雑誌)
出版者・発行元
AMER ASSOC IMMUNOLOGISTS

We analyzed the responses of several T cell fractions reactive with superantigenic toxins (SAGTs), staphylococcal enterotoxin A (SEA), or Yersinia pseudotuberculosis-derived mitogen (YPM) in mice implanted with mini-osmotic pumps filled with SEA or YPM. In mice implanted with the SEA pump, SEA-reactive Vbeta3(+)CD4(+) T cells exhibited a high-level protracted expansion for 30 days, and SEA-reactive Vbeta11(+)CD4(+) T cells exhibited a low-level protracted expansion. SEA-reactive CD8(+) counterparts exhibited only a transient expansion. A similar difference in T cell expansion was also observed in YPM-reactive T cell fractions in mice implanted with the YPM pump. Vbeta3(+)CD4(+) and Vbeta11(+)CD4(+) T cells from mice implanted with the SEA pump exhibited cell divisions upon In vitro restimulation with SEA and expressed surface phenotypes as memory T cells. CD4(+) T cells from mice implanted with the SEA pump exhibited high IL-4 production upon in vitro restimulation with SEA, which was due to the enhanced capacity of the SEA-reactive CD4(+) T cells to produce IL-4. The findings in the present study indicate that, in mice implanted with a specific SAGT, the level of expansion of the SAGT-reactive CD4(+) T cell fractions varies widely depending on the TCR Vbeta elements expressed and that the reactive CD4(+) T cells acquire a capacity to raise a memory response. CD8(+) T cells are low responders to SAGTs.

Web of Science ® 被引用回数 : 24

リンク情報
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/11937534
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000174913300019&DestApp=WOS_CPL

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