2017年12月1日
Third Ventricle Germ Cell Tumor Originating from the Infundibulum with Rapidly Expansive Enlargement
Pediatric Neurosurgery
- ,
- ,
- ,
- ,
- ,
- 巻
- 53
- 号
- 1
- 開始ページ
- 49
- 終了ページ
- 54
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1159/000480021
- 出版者・発行元
- S. Karger AG
We present a pediatric case of a rapidly expanding third ventricle germ cell tumor (GCT). A 14-year-old boy suffered from gradual-onset central diabetes insipidus (DI) and received desmopressin treatment. Magnetic resonance imaging (MRI) showed nonspecific findings of the pituitary-hypothalamic axis. Nine months after the initial DI diagnosis, he developed progressively worsening headache. MRI demonstrated a third ventricle tumor causing noncommunicating hydrocephalus, although an MRI 16 weeks before admission did not show the lesion. We performed gross total resection (GTR) of the tumor in 2 stages: a translamina terminalis approach and an extended transsphenoidal approach. The lesion was histologically diagnosed as immature teratoma with some germinoma. His noncommunicating hydrocephalus resolved after surgery. Through postoperative radiochemotherapy (whole ventricle: 23.4 Gy/13 fractions, tumor bed: 27.0 Gy/15 fractions, and 3 courses of carboplatin-etoposide), he has was in complete remission at the 3-year follow-up and has continued his high school program. This case suggests the following: (1) a mixed GCT originating from the neurohypophysis/infundibulum can show rapidly expansive growth in a child with central DI
(2) GTR and adjuvant radiochemotherapy can result in a good therapeutic outcome in rapidly expanding GCT
and (3) the extended transsphenoidal approach is a complementary approach to transcranial resection of anterior third ventricle GCTs.
(2) GTR and adjuvant radiochemotherapy can result in a good therapeutic outcome in rapidly expanding GCT
and (3) the extended transsphenoidal approach is a complementary approach to transcranial resection of anterior third ventricle GCTs.
- ID情報
-
- DOI : 10.1159/000480021
- ISSN : 1423-0305
- ISSN : 1016-2291
- PubMed ID : 28946146
- SCOPUS ID : 85030166017