2008年6月
Topical capsaicin application causes cold hypersensitivity in awake monkeys.
Journal of oral science
- 巻
- 50
- 号
- 2
- 開始ページ
- 175
- 終了ページ
- 179
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.2334/josnusd.50.175
- 出版者・発行元
- 2
Recent animal studies have demonstrated that many trigeminal ganglion neurons co-express TRPV1 and TRPA1 receptors following peripheral inflammation. In the present study, we examined whether cold receptors were sensitized by capsaicin in awake monkeys. Two monkeys were trained to detect a change in cold stimulus temperature (30°C to 0.5, 1.0, 1.5 or 2.0°C) applied to the facial skin. A total of 589 trials were studied, and the number of escape and hold-through trials and detection latency were measured. The number of escape trials was increased after capsaicin treatment, whereas that of hold-through trials was decreased. Detection latency was significantly decreased after capsaicin treatment. The present findings suggest that topical application of capsaicin to the facial skin induces reversible hypersensitivity to a facial cold stimulus in behaving monkeys. (J. Oral Sci. 50, 175-179, 2008)
- リンク情報
- ID情報
-
- DOI : 10.2334/josnusd.50.175
- ISSN : 1343-4934
- ISSN : 1880-4926
- CiNii Articles ID : 130000072841