2020年4月9日
Rare Genotype of His/His in NUDT15 Codon 139 and Thiopurine-associated Adverse Events in a Case of Ulcerative Colitis.
Internal medicine (Tokyo, Japan)
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- 巻
- 59
- 号
- 13
- 開始ページ
- 1611
- 終了ページ
- 1613
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2169/internalmedicine.4261-19
Thiopurine drugs are commonly used to treat immunologic diseases. However, the narrow therapeutic safety margin demands evidence-based precision medicine approaches. NUDT15 variants are associated with thiopurine-induced adverse events, particularly in Asians. We herein report a rare genotype of His/His in NUDT15 codon 139 in a case of ulcerative colitis and review the relevant literature. The patient experienced severe thiopurine-associated adverse events, including leukopenia and alopecia. There is no literature on the His/His genotype in NUDT15 codon 139, and our case suggests cautious use or the contraindication of thiopurines for patients with this genotype.
- リンク情報
- ID情報
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- DOI : 10.2169/internalmedicine.4261-19
- PubMed ID : 32269192
- PubMed Central 記事ID : PMC7402964