2012年
Dipicolylamine as a unique structural switching element for helical peptides
ORGANIC & BIOMOLECULAR CHEMISTRY
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- 巻
- 10
- 号
- 30
- 開始ページ
- 6062
- 終了ページ
- 6068
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1039/c2ob07118e
- 出版者・発行元
- ROYAL SOC CHEMISTRY
Developing novel methods for metal-induced switching of peptide structures expands the design principles of functional biomolecules and biomaterials. Here, a simple method for on-resin synthesis of dipicolylamine (Dpa)-containing peptides was developed. Whereas addition of divalent metal ions such as Fe(II) and Cu(II) to a peptide bearing a pair of Dpa moieties at the i and i + 4 positions led to the formation of a 1 : 1 complex of Dpa with metals, addition of Ni(II) yielded a cross-linked structure of Dpa-metal (2 : 1). This feature was utilized for the selective detection of Ni(II) using the peptide-Fe(II) complex. Repeated switching of the helical structure was also achieved by multiple additions of divalent metal ions to the peptide.
- リンク情報
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- DOI
- https://doi.org/10.1039/c2ob07118e
- J-GLOBAL
- https://jglobal.jst.go.jp/detail?JGLOBAL_ID=201202281784434806
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/22613959
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000306276800055&DestApp=WOS_CPL
- URL
- http://www.scopus.com/inward/record.url?eid=2-s2.0-84863887518&partnerID=MN8TOARS
- URL
- http://orcid.org/0000-0002-4172-0966
- ID情報
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- DOI : 10.1039/c2ob07118e
- ISSN : 1477-0520
- J-Global ID : 201202281784434806
- ORCIDのPut Code : 44910685
- PubMed ID : 22613959
- SCOPUS ID : 84863887518
- Web of Science ID : WOS:000306276800055