論文

査読有り
2020年6月

Radiotherapy planning techniques to reduce lung irradiation in head and neck cancer patients with mediastinal involvement.

Radiological physics and technology
  • Mitsue Kawamura
  • ,
  • Michio Yoshimura
  • ,
  • Mitsuhiro Nakamura
  • ,
  • Yoshitomo Ishihara
  • ,
  • Nobutaka Mukumoto
  • ,
  • Hideaki Hirashima
  • ,
  • Hiraku Iramina
  • ,
  • Masahiro Hiraoka
  • ,
  • Takashi Mizowaki

13
2
開始ページ
128
終了ページ
135
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s12194-020-00559-2

The number of patients with head and neck squamous cell carcinoma (HNC) with mediastinal involvement is small, and appropriate treatment techniques have not been widely discussed. This study aimed to compare the efficacy of radiotherapy planning techniques in reducing lung irradiation while retaining target coverage. Among all HNC patients with mediastinal involvement who underwent radiotherapy between 2007 and 2014 at our hospital, seven consecutive patients were included in this study. Four different treatment plans were generated for each patient as follows: seven-field intensity-modulated radiation therapy (IMRT), modified IMRT in which the lateral beams avoided the lungs, three-full-arc volumetric-modulated arc therapy (VMAT), and VMAT with lung avoidance. We compared the outcomes of IMRT and VMAT plans using the paired t-test. After modifications were made to avoid lung irradiation, IMRT values for V5Gy and V20Gy decreased from 713.2 to 503.6 cm3 (p = 0.011) and from 338.8 cm3 to 267.0 cm3 (p = 0.058), respectively. In the case of VMAT, lung V5Gy and V20Gy values decreased from 754.8 to 601.0 cm3 (p = 0.004) and from 328.5 to 255.7 cm3 (p = 0.020), respectively. Other factors did not significantly differ between the plans. In both IMRT and VMAT planning, lung doses were significantly reduced following the modification of the beams that cross the lungs with target coverage maintenance.

リンク情報
DOI
https://doi.org/10.1007/s12194-020-00559-2
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/32157573
ID情報
  • DOI : 10.1007/s12194-020-00559-2
  • PubMed ID : 32157573

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